Human Gene RGS20 (ENST00000276500.5_8) from GENCODE V47lift37
Description: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)- i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). (from UniProt O76081) Gencode Transcript: ENST00000276500.5_8 Gencode Gene: ENSG00000147509.14_13 Transcript (Including UTRs) Position: hg19 chr8:54,793,432-54,871,863 Size: 78,432 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chr8:54,793,576-54,871,018 Size: 77,443 Coding Exon Count: 5
ID:RGS20_HUMAN DESCRIPTION: RecName: Full=Regulator of G-protein signaling 20; Short=RGS20; AltName: Full=Gz-selective GTPase-activating protein; Short=G(z)GAP; Short=Gz-GAP; AltName: Full=Regulator of G-protein signaling Z1; AltName: Full=Regulator of Gz-selective protein signaling 1; FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). SUBUNIT: Forms a complex with G(alpha)z/i2 subunits and mu-opioid receptors; the formation of this complex results in mu-opioid receptor desensitization. Interacts with OPRM1 (By similarity). SUBCELLULAR LOCATION: Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus (By similarity). Anchored to the membrane through palmitoylation (By similarity). TISSUE SPECIFICITY: Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe. PTM: Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity). PTM: N- and O-glycosylated in synapsomal membranes (By similarity). PTM: Serine phosphorylated in synapsomal membranes (By similarity). PTM: Sumoylated with SUMO1 and SUMO2 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits (By similarity). SIMILARITY: Contains 1 RGS domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00615 - Regulator of G protein signaling domain
SCOP Domains: 48097 - Regulator of G-protein signaling, RGS
ModBase Predicted Comparative 3D Structure on O76081
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005096 GTPase activator activity GO:0005515 protein binding
Biological Process: GO:0008277 regulation of G-protein coupled receptor protein signaling pathway GO:0009968 negative regulation of signal transduction GO:0043547 positive regulation of GTPase activity
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
