Human Gene RGS16 (ENST00000367558.6_7) from GENCODE V47lift37

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Description: regulator of G protein signaling 16 (from RefSeq NM_002928.4)
Gencode Transcript: ENST00000367558.6_7
Gencode Gene: ENSG00000143333.7_9
Transcript (Including UTRs)
Position: hg19 chr1:182,567,758-182,573,524 Size: 5,767 Total Exon Count: 5 Strand: -
Coding Region
Position: hg19 chr1:182,569,427-182,573,394 Size: 3,968 Coding Exon Count: 5

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:182,567,758-182,573,524)			mRNA (may differ from genome)		Protein (202 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: RGS16_HUMAN DESCRIPTION: RecName: Full=Regulator of G-protein signaling 16; Short=RGS16; AltName: Full=A28-RGS14P; AltName: Full=Retinal-specific RGS; Short=RGS-r; Short=hRGS-r; AltName: Full=Retinally abundant regulator of G-protein signaling; FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. May play a role in regulating the kinetics of signaling in the phototransduction cascade. ENZYME REGULATION: Phosphorylation at Tyr-168 by EGFR enhances GTPase accelerating (GAP) activity toward GNAI1. TISSUE SPECIFICITY: Abundantly expressed in retina with lower levels of expression in most other tissues. PTM: Palmitoylated on Cys-2 and/or Cys-12 (By similarity). PTM: Phosphorylated. Regulated by phosphorylation at Tyr-168 by EGFR upon stimulation by EGF. SIMILARITY: Contains 1 RGS domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D016604 Aflatoxin B1 D016572 Cyclosporine D004958 Estradiol D010634 Phenobarbital D013629 Tamoxifen D013749 Tetrachlorodibenzodioxin D014212 Tretinoin C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 36.53 RPKM in Thyroid Total median expression: 264.18 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-40.10	130	-0.308	Picture	PostScript	Text
3' UTR	-607.70	1669	-0.364	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000342 - Regulat_G_prot_signal
IPR024066 - Regulat_G_prot_signal_dom1
IPR016137 - Regulat_G_prot_signal_superfam

Pfam Domains:
PF00615 - Regulator of G protein signaling domain

SCOP Domains:
48097 - Regulator of G-protein signaling, RGS

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2BT2 - X-ray MuPIT

2IK8 - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on O15492


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005096 GTPase activator activity GO:0005515 protein binding GO:0005516 calmodulin binding Biological Process: GO:0007186 G-protein coupled receptor signaling pathway GO:0007601 visual perception GO:0008277 regulation of G-protein coupled receptor protein signaling pathway GO:0009968 negative regulation of signal transduction GO:0043547 positive regulation of GTPase activity Cellular Component: GO:0005737 cytoplasm GO:0005886 plasma membrane GO:0016020 membrane GO:0031224 intrinsic component of membrane

Descriptions from all associated GenBank mRNAs


	LF205402 - JP 2014500723-A/12905: Polycomb-Associated Non-Coding RNAs. LF205400 - JP 2014500723-A/12903: Polycomb-Associated Non-Coding RNAs. U70426 - Homo sapiens A28-RGS14p mRNA, complete cds. JD124297 - Sequence 105321 from Patent EP1572962. JD540622 - Sequence 521646 from Patent EP1572962. JD314359 - Sequence 295383 from Patent EP1572962. JD419076 - Sequence 400100 from Patent EP1572962. U94829 - Human retinally abundant regulator of G-protein signaling hRGS-r (hRGS-r) mRNA, complete cds. JD105373 - Sequence 86397 from Patent EP1572962. LF320134 - JP 2014500723-A/127637: Polycomb-Associated Non-Coding RNAs. JD150337 - Sequence 131361 from Patent EP1572962. JD259388 - Sequence 240412 from Patent EP1572962. JD047072 - Sequence 28096 from Patent EP1572962. JD142021 - Sequence 123045 from Patent EP1572962. JD423203 - Sequence 404227 from Patent EP1572962. JD399935 - Sequence 380959 from Patent EP1572962. LF320133 - JP 2014500723-A/127636: Polycomb-Associated Non-Coding RNAs. JD194976 - Sequence 176000 from Patent EP1572962. JD426135 - Sequence 407159 from Patent EP1572962. JD334932 - Sequence 315956 from Patent EP1572962. JD262014 - Sequence 243038 from Patent EP1572962. JD474228 - Sequence 455252 from Patent EP1572962. LF320132 - JP 2014500723-A/127635: Polycomb-Associated Non-Coding RNAs. JD206330 - Sequence 187354 from Patent EP1572962. JD540877 - Sequence 521901 from Patent EP1572962. JD430655 - Sequence 411679 from Patent EP1572962. JD413936 - Sequence 394960 from Patent EP1572962. JD133606 - Sequence 114630 from Patent EP1572962. JD131236 - Sequence 112260 from Patent EP1572962. LF320131 - JP 2014500723-A/127634: Polycomb-Associated Non-Coding RNAs. JD367987 - Sequence 349011 from Patent EP1572962. JD516933 - Sequence 497957 from Patent EP1572962. JD305188 - Sequence 286212 from Patent EP1572962. JD428704 - Sequence 409728 from Patent EP1572962. JD106147 - Sequence 87171 from Patent EP1572962. LF320129 - JP 2014500723-A/127632: Polycomb-Associated Non-Coding RNAs. BC006243 - Homo sapiens regulator of G-protein signaling 16, mRNA (cDNA clone MGC:10379 IMAGE:3946461), complete cds. JD471744 - Sequence 452768 from Patent EP1572962. JD283956 - Sequence 264980 from Patent EP1572962. JD391183 - Sequence 372207 from Patent EP1572962. JD459022 - Sequence 440046 from Patent EP1572962. JD057666 - Sequence 38690 from Patent EP1572962. JD173328 - Sequence 154352 from Patent EP1572962. JD194124 - Sequence 175148 from Patent EP1572962. AF493937 - Homo sapiens regulator of G protein signalling 16 (RGS16) mRNA, complete cds. AK311880 - Homo sapiens cDNA, FLJ92146, highly similar to Homo sapiens regulator of G-protein signalling 16 (RGS16), mRNA. CU675307 - Synthetic construct Homo sapiens gateway clone IMAGE:100018555 5' read RGS16 mRNA. BT006638 - Homo sapiens regulator of G-protein signalling 16 mRNA, complete cds. AB528682 - Synthetic construct DNA, clone: pF1KB6896, Homo sapiens RGS16 gene for regulator of G-protein signaling 16, without stop codon, in Flexi system. LF320128 - JP 2014500723-A/127631: Polycomb-Associated Non-Coding RNAs. LF320127 - JP 2014500723-A/127630: Polycomb-Associated Non-Coding RNAs. AK301261 - Homo sapiens cDNA FLJ57620 complete cds, highly similar to Regulator of G-protein signaling 16. LF211764 - JP 2014500723-A/19267: Polycomb-Associated Non-Coding RNAs. LF320124 - JP 2014500723-A/127627: Polycomb-Associated Non-Coding RNAs. LF320123 - JP 2014500723-A/127626: Polycomb-Associated Non-Coding RNAs. LF320122 - JP 2014500723-A/127625: Polycomb-Associated Non-Coding RNAs. JD255173 - Sequence 236197 from Patent EP1572962. MA440979 - JP 2018138019-A/12905: Polycomb-Associated Non-Coding RNAs. MA440977 - JP 2018138019-A/12903: Polycomb-Associated Non-Coding RNAs. MA555711 - JP 2018138019-A/127637: Polycomb-Associated Non-Coding RNAs. MA555710 - JP 2018138019-A/127636: Polycomb-Associated Non-Coding RNAs. MA555709 - JP 2018138019-A/127635: Polycomb-Associated Non-Coding RNAs. MA555708 - JP 2018138019-A/127634: Polycomb-Associated Non-Coding RNAs. MA555706 - JP 2018138019-A/127632: Polycomb-Associated Non-Coding RNAs. MA555705 - JP 2018138019-A/127631: Polycomb-Associated Non-Coding RNAs. MA555704 - JP 2018138019-A/127630: Polycomb-Associated Non-Coding RNAs. MA447341 - JP 2018138019-A/19267: Polycomb-Associated Non-Coding RNAs. MA555701 - JP 2018138019-A/127627: Polycomb-Associated Non-Coding RNAs. MA555700 - JP 2018138019-A/127626: Polycomb-Associated Non-Coding RNAs. MA555699 - JP 2018138019-A/127625: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: B2R4M4, ENST00000367558.1, ENST00000367558.2, ENST00000367558.3, ENST00000367558.4, ENST00000367558.5, NM_002928, O15492, Q5VYN9, Q99701, RGS16_HUMAN, RGSR, uc318fzz.1, uc318fzz.2 UCSC ID: ENST00000367558.6_7 RefSeq Accession: NM_002928.4 Protein: O15492 (aka RGS16_HUMAN or RGSG_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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