Human Gene RBM14 (ENST00000310137.5_8) from GENCODE V47lift37

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Description: RNA binding motif protein 14, transcript variant 1 (from RefSeq NM_006328.4)
Gencode Transcript: ENST00000310137.5_8
Gencode Gene: ENSG00000239306.5_10
Transcript (Including UTRs)
Position: hg19 chr11:66,384,101-66,397,405 Size: 13,305 Total Exon Count: 3 Strand: +
Coding Region
Position: hg19 chr11:66,384,192-66,394,139 Size: 9,948 Coding Exon Count: 3

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr11:66,384,101-66,397,405)			mRNA (may differ from genome)		Protein (669 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: RBM14_HUMAN DESCRIPTION: RecName: Full=RNA-binding protein 14; AltName: Full=Paraspeckle protein 2; Short=PSP2; AltName: Full=RNA-binding motif protein 14; AltName: Full=RRM-containing coactivator activator/modulator; AltName: Full=Synaptotagmin-interacting protein; Short=SYT-interacting protein; FUNCTION: Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1. SUBUNIT: Isoform 1 interacts with NCOA6, CITED1 and XRCC5/KU86. Isoform 1 interacts with SS18 isoform 1. Isoform 1 interacts with SS18 isoform 2. SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. TISSUE SPECIFICITY: Expressed in all tissues tested, including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood lymphocytes. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D004958 Estradiol C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine C009505 4,4'-diaminodiphenylmethane D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000393 Air Pollutants D000643 Ammonium Chloride D017638 Asbestos, Crocidolite D001564 Benzo(a)pyrene C408982 CPG-oligonucleotide more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 33.94 RPKM in Testis Total median expression: 776.42 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-37.30	91	-0.410	Picture	PostScript	Text
3' UTR	-1084.20	3266	-0.332	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR012677 - Nucleotide-bd_a/b_plait
IPR000504 - RRM_dom

Pfam Domains:
PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PF13893 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

SCOP Domains:
54928 - RNA-binding domain, RBD

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2DNP - NMR MuPIT

ModBase Predicted Comparative 3D Structure on Q96PK6


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0001104 RNA polymerase II transcription cofactor activity GO:0003676 nucleic acid binding GO:0003723 RNA binding GO:0005515 protein binding GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity GO:0030674 protein binding, bridging Biological Process: GO:0002218 activation of innate immune response GO:0002376 immune system process GO:0006260 DNA replication GO:0006281 DNA repair GO:0006310 DNA recombination GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0009725 response to hormone GO:0016575 histone deacetylation GO:0030520 intracellular estrogen receptor signaling pathway GO:0042921 glucocorticoid receptor signaling pathway GO:0045087 innate immune response GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046600 negative regulation of centriole replication GO:0060395 SMAD protein signal transduction GO:0098534 centriole assembly Cellular Component: GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005667 transcription factor complex GO:0005730 nucleolus GO:0005737 cytoplasm GO:0016592 mediator complex GO:0016607 nuclear speck GO:1990904 ribonucleoprotein complex

Descriptions from all associated GenBank mRNAs


	LF214054 - JP 2014500723-A/21557: Polycomb-Associated Non-Coding RNAs. AF315633 - Homo sapiens coactivator modulator mRNA, complete cds, alternatively spliced. AF315632 - Homo sapiens coactivator activator mRNA, complete cds, alternatively spliced. EU287938 - Homo sapiens transcriptional coactivator CoAZ (RBM14/RBM4 fusion) mRNA, complete cds, alternatively spliced. AK222830 - Homo sapiens mRNA for RNA binding motif protein 14 variant, clone: HEP05339. AK307254 - Homo sapiens cDNA, FLJ97202. AK297907 - Homo sapiens cDNA FLJ59137 complete cds, highly similar to RNA-binding protein 14. AK021768 - Homo sapiens cDNA FLJ11706 fis, clone HEMBA1005101, highly similar to RNA-binding protein 14. AK292805 - Homo sapiens cDNA FLJ78260 complete cds, highly similar to Homo sapiens RNA binding motif protein 4, mRNA. AF080561 - Homo sapiens SYT interacting protein SIP mRNA, complete cds. BC000488 - Homo sapiens RNA binding motif protein 14, mRNA (cDNA clone MGC:8361 IMAGE:2819856), complete cds. BC023619 - Homo sapiens RNA binding motif protein 14, mRNA (cDNA clone IMAGE:4651407). JD395815 - Sequence 376839 from Patent EP1572962. DQ294957 - Homo sapiens coactivator regulator (RBM14) mRNA, complete cds, alternatively spliced. KU178520 - Homo sapiens RNA binding motif protein 14 isoform 1 (RBM14) mRNA, partial cds. KU178521 - Homo sapiens RNA binding motif protein 14 isoform 2 (RBM14) mRNA, complete cds. KU178522 - Homo sapiens RNA binding motif protein 14 isoform 3 (RBM14) mRNA, complete cds. EU446504 - Synthetic construct Homo sapiens clone IMAGE:100070238; IMAGE:100011713; FLH258209.01L RNA binding motif protein 14 (RBM14) gene, encodes complete protein. KJ893035 - Synthetic construct Homo sapiens clone ccsbBroadEn_02429 RBM14 gene, encodes complete protein. EU287939 - Homo sapiens non-coding transcriptional coactivator CoAZ (RBM14/RBM4 fusion), complete sequence, alternatively spliced. DQ590326 - Homo sapiens piRNA piR-57438, complete sequence. AB209007 - Homo sapiens mRNA for RNA binding motif protein 14 variant protein. LF211150 - JP 2014500723-A/18653: Polycomb-Associated Non-Coding RNAs. LF344292 - JP 2014500723-A/151795: Polycomb-Associated Non-Coding RNAs. LF344291 - JP 2014500723-A/151794: Polycomb-Associated Non-Coding RNAs. LF344290 - JP 2014500723-A/151793: Polycomb-Associated Non-Coding RNAs. LF344289 - JP 2014500723-A/151792: Polycomb-Associated Non-Coding RNAs. LF344288 - JP 2014500723-A/151791: Polycomb-Associated Non-Coding RNAs. LF344286 - JP 2014500723-A/151789: Polycomb-Associated Non-Coding RNAs. LF344285 - JP 2014500723-A/151788: Polycomb-Associated Non-Coding RNAs. CR749306 - Homo sapiens mRNA; cDNA DKFZp779J0927 (from clone DKFZp779J0927). LF344279 - JP 2014500723-A/151782: Polycomb-Associated Non-Coding RNAs. JD344239 - Sequence 325263 from Patent EP1572962. JD307756 - Sequence 288780 from Patent EP1572962. JD122449 - Sequence 103473 from Patent EP1572962. JD332565 - Sequence 313589 from Patent EP1572962. JD067170 - Sequence 48194 from Patent EP1572962. JD179448 - Sequence 160472 from Patent EP1572962. JD492600 - Sequence 473624 from Patent EP1572962. JD467662 - Sequence 448686 from Patent EP1572962. JD133265 - Sequence 114289 from Patent EP1572962. JD079440 - Sequence 60464 from Patent EP1572962. BC024260 - Homo sapiens RNA binding motif protein 14, mRNA (cDNA clone IMAGE:3535517), complete cds. BC007641 - Homo sapiens RNA binding motif protein 14, mRNA (cDNA clone IMAGE:3534121), complete cds. JD480928 - Sequence 461952 from Patent EP1572962. JD427393 - Sequence 408417 from Patent EP1572962. AB464693 - Synthetic construct DNA, clone: pF1KB9795, Homo sapiens RBM14 gene for RNA binding motif protein 14, without stop codon, in Flexi system. KJ904652 - Synthetic construct Homo sapiens clone ccsbBroadEn_14046 RBM14 gene, encodes complete protein. JD546197 - Sequence 527221 from Patent EP1572962. JD282830 - Sequence 263854 from Patent EP1572962. JD491467 - Sequence 472491 from Patent EP1572962. JD527609 - Sequence 508633 from Patent EP1572962. JD528048 - Sequence 509072 from Patent EP1572962. JD495483 - Sequence 476507 from Patent EP1572962. JD159202 - Sequence 140226 from Patent EP1572962. JD563595 - Sequence 544619 from Patent EP1572962. JD552223 - Sequence 533247 from Patent EP1572962. JD270842 - Sequence 251866 from Patent EP1572962. JD085349 - Sequence 66373 from Patent EP1572962. JD502208 - Sequence 483232 from Patent EP1572962. JD437865 - Sequence 418889 from Patent EP1572962. JD384709 - Sequence 365733 from Patent EP1572962. JD283190 - Sequence 264214 from Patent EP1572962. JD508616 - Sequence 489640 from Patent EP1572962. JD337435 - Sequence 318459 from Patent EP1572962. JD197840 - Sequence 178864 from Patent EP1572962. JD512830 - Sequence 493854 from Patent EP1572962. JD469697 - Sequence 450721 from Patent EP1572962. JD507526 - Sequence 488550 from Patent EP1572962. MA449631 - JP 2018138019-A/21557: Polycomb-Associated Non-Coding RNAs. MA579869 - JP 2018138019-A/151795: Polycomb-Associated Non-Coding RNAs. MA579868 - JP 2018138019-A/151794: Polycomb-Associated Non-Coding RNAs. MA579867 - JP 2018138019-A/151793: Polycomb-Associated Non-Coding RNAs. MA579866 - JP 2018138019-A/151792: Polycomb-Associated Non-Coding RNAs. MA579865 - JP 2018138019-A/151791: Polycomb-Associated Non-Coding RNAs. MA579863 - JP 2018138019-A/151789: Polycomb-Associated Non-Coding RNAs. MA579862 - JP 2018138019-A/151788: Polycomb-Associated Non-Coding RNAs. MA579856 - JP 2018138019-A/151782: Polycomb-Associated Non-Coding RNAs. MA446727 - JP 2018138019-A/18653: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q96PK6 (Reactome details) participates in the following event(s): R-HSA-8938356 RMB14 binds RUNX2 R-HSA-8941326 RUNX2 regulates bone development R-HSA-8878166 Transcriptional regulation by RUNX2 R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)

Other Names for This Gene


	Alternate Gene Symbols: B0LM41, B3KMN4, D6RGD8, ENST00000310137.1, ENST00000310137.2, ENST00000310137.3, ENST00000310137.4, NM_006328, O75932, Q2PYN1, Q53GV1, Q68DQ9, Q96PK5, Q96PK6, RBM14_HUMAN, SIP, uc317oru.1, uc317oru.2 UCSC ID: ENST00000310137.5_8 RefSeq Accession: NM_006328.4 Protein: Q96PK6 (aka RBM14_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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