Human Gene RALGAPA1 (ENST00000680220.1_6) from GENCODE V47lift37

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Description: Ral GTPase activating protein catalytic subunit alpha 1, transcript variant 11 (from RefSeq NM_001346249.2)
Gencode Transcript: ENST00000680220.1_6
Gencode Gene: ENSG00000174373.17_17
Transcript (Including UTRs)
Position: hg19 chr14:36,007,562-36,278,501 Size: 270,940 Total Exon Count: 42 Strand: -
Coding Region
Position: hg19 chr14:36,017,737-36,278,041 Size: 260,305 Coding Exon Count: 41

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Other Names	Model Information
Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr14:36,007,562-36,278,501)			mRNA (may differ from genome)		Protein (2542 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: RALGAPA1 Diseases sorted by gene-association score: holoprosencephaly 8 (10), ebola hemorrhagic fever (7)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C023514 2,6-dinitrotoluene C030370 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone C035207 4-amino-2,6-dinitrotoluene D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000082 Acetaminophen D000643 Ammonium Chloride D001564 Benzo(a)pyrene D002857 Chromium D019327 Copper Sulfate D003375 Coumestrol more ... click here to view the complete list

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-248.10	460	-0.539	Picture	PostScript	Text
3' UTR	-321.10	1358	-0.236	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details		Gene Details
Gene Sorter	Gene Sorter		Gene Sorter
	RGD

Descriptions from all associated GenBank mRNAs


	AY596970 - Homo sapiens tuberin-like protein 1 isoform 1 (GARNL1) mRNA, complete cds, alternatively spliced. AY596971 - Homo sapiens tuberin-like protein 1 isoform 2 (GARNL1) mRNA, complete cds, alternatively spliced. BC042013 - Homo sapiens GTPase activating Rap/RanGAP domain-like 1, mRNA (cDNA clone IMAGE:5311466), partial cds. DQ786317 - Homo sapiens clone HLS_IMAGE_815163 mRNA sequence. AL834362 - Homo sapiens mRNA; cDNA DKFZp667F074 (from clone DKFZp667F074). AK126975 - Homo sapiens cDNA FLJ45028 fis, clone BRAWH3018063, highly similar to Rattus norvegicus tuberin-like protein 1 (Tulip1). BC042045 - Homo sapiens GTPase activating Rap/RanGAP domain-like 1, mRNA (cDNA clone IMAGE:5527017), partial cds. BC150596 - Homo sapiens GTPase activating Rap/RanGAP domain-like 1, mRNA (cDNA clone MGC:183506 IMAGE:9056966), complete cds. AB511280 - Homo sapiens GARNL1 mRNA for RalGAP alpha1 catalytic subunit, complete cds. BC168361 - Synthetic construct Homo sapiens clone IMAGE:100068257, MGC:195874 GTPase activating Rap/RanGAP domain-like 1 (GARNL1) mRNA, encodes complete protein. AB020691 - Homo sapiens mRNA for KIAA0884 protein, partial cds. AK022988 - Homo sapiens cDNA FLJ12926 fis, clone NT2RP2004732, weakly similar to NEUROFILAMENT TRIPLET M PROTEIN. JD236984 - Sequence 218008 from Patent EP1572962. JD245524 - Sequence 226548 from Patent EP1572962. JD535953 - Sequence 516977 from Patent EP1572962. JD563460 - Sequence 544484 from Patent EP1572962. JD412232 - Sequence 393256 from Patent EP1572962. JD564698 - Sequence 545722 from Patent EP1572962. JD334453 - Sequence 315477 from Patent EP1572962. JD159750 - Sequence 140774 from Patent EP1572962. JD264813 - Sequence 245837 from Patent EP1572962. JD429358 - Sequence 410382 from Patent EP1572962. JD546470 - Sequence 527494 from Patent EP1572962. JD553501 - Sequence 534525 from Patent EP1572962. JD367952 - Sequence 348976 from Patent EP1572962. JD263304 - Sequence 244328 from Patent EP1572962. JD352810 - Sequence 333834 from Patent EP1572962. JD444878 - Sequence 425902 from Patent EP1572962. JD096485 - Sequence 77509 from Patent EP1572962. JD067139 - Sequence 48163 from Patent EP1572962. JD233507 - Sequence 214531 from Patent EP1572962. JD306676 - Sequence 287700 from Patent EP1572962. JD061867 - Sequence 42891 from Patent EP1572962. JD490136 - Sequence 471160 from Patent EP1572962. JD246030 - Sequence 227054 from Patent EP1572962. JD081706 - Sequence 62730 from Patent EP1572962. JD516077 - Sequence 497101 from Patent EP1572962. JD422991 - Sequence 404015 from Patent EP1572962. JD245004 - Sequence 226028 from Patent EP1572962. JD350489 - Sequence 331513 from Patent EP1572962. JD552861 - Sequence 533885 from Patent EP1572962. JD364052 - Sequence 345076 from Patent EP1572962. JD327322 - Sequence 308346 from Patent EP1572962. BC016305 - Homo sapiens GTPase activating Rap/RanGAP domain-like 1, mRNA (cDNA clone IMAGE:4076117), partial cds. JD206686 - Sequence 187710 from Patent EP1572962. JD424546 - Sequence 405570 from Patent EP1572962. JD351935 - Sequence 332959 from Patent EP1572962. JD244494 - Sequence 225518 from Patent EP1572962. JD102418 - Sequence 83442 from Patent EP1572962. JD042492 - Sequence 23516 from Patent EP1572962. JD495031 - Sequence 476055 from Patent EP1572962. JD411204 - Sequence 392228 from Patent EP1572962. JD301631 - Sequence 282655 from Patent EP1572962. JD277471 - Sequence 258495 from Patent EP1572962. JD401878 - Sequence 382902 from Patent EP1572962. JD159882 - Sequence 140906 from Patent EP1572962. JD037699 - Sequence 18723 from Patent EP1572962. JD111537 - Sequence 92561 from Patent EP1572962. JD264021 - Sequence 245045 from Patent EP1572962. JD181869 - Sequence 162893 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A0A7P0TAR5, A0A7P0TAR5_HUMAN, NM_001346249, RALGAPA1 , uc330gqr.1, uc330gqr.2 UCSC ID: ENST00000680220.1_6 RefSeq Accession: NM_001346249.2

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.