Human Gene RAI14 (ENST00000265109.8_7) from GENCODE V47lift37
  Description: retinoic acid induced 14, transcript variant 1 (from RefSeq NM_015577.3)
Gencode Transcript: ENST00000265109.8_7
Gencode Gene: ENSG00000039560.14_12
Transcript (Including UTRs)
   Position: hg19 chr5:34,656,433-34,832,717 Size: 176,285 Total Exon Count: 18 Strand: +
Coding Region
   Position: hg19 chr5:34,687,025-34,830,870 Size: 143,846 Coding Exon Count: 17 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:34,656,433-34,832,717)mRNA (may differ from genome)Protein (980 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RAI14_HUMAN
DESCRIPTION: RecName: Full=Ankycorbin; AltName: Full=Ankyrin repeat and coiled-coil structure-containing protein; AltName: Full=Novel retinal pigment epithelial cell protein; AltName: Full=Retinoic acid-induced protein 14;
SUBUNIT: Doesn't bind directly to F-actin (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cell cortex (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associated with the cortical actin cytoskeleton structures in terminal web and cell- cell adhesion sites and stress fibers (By similarity).
TISSUE SPECIFICITY: Highly expressed in placenta, muscle, kidney and testis. Moderately expressed in heart, brain, lung, liver and intestine. Isoform 2 is widely expressed and expressed in fetal and adult testes, and spermatozoa.
INDUCTION: Up-regulated by all-trans-retinoic acid (ATRA) in retinal pigment epithelial cells (ARPE-19).
SIMILARITY: Contains 7 ANK repeats.
SEQUENCE CAUTION: Sequence=BAA92572.1; Type=Erroneous initiation; Sequence=CAB43236.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.43 RPKM in Cells - Cultured fibroblasts
Total median expression: 364.23 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -88.30196-0.451 Picture PostScript Text
3' UTR -483.001847-0.262 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom

Pfam Domains:
PF00023 - Ankyrin repeat
PF12796 - Ankyrin repeats (3 copies)
PF13606 - Ankyrin repeat
PF13637 - Ankyrin repeats (many copies)
PF13857 - Ankyrin repeats (many copies)

SCOP Domains:
140860 - Pseudo ankyrin repeat-like
47661 - t-snare proteins
48403 - Ankyrin repeat
57997 - Tropomyosin

ModBase Predicted Comparative 3D Structure on Q9P0K7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0007283 spermatogenesis
GO:0030154 cell differentiation

Cellular Component:
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005938 cell cortex
GO:0030054 cell junction


-  Descriptions from all associated GenBank mRNAs
  BC052988 - Homo sapiens retinoic acid induced 14, mRNA (cDNA clone MGC:60196 IMAGE:6164087), complete cds.
AF155135 - Homo sapiens novel retinal pigment epithelial cell protein (NORPEG) mRNA, complete cds.
AK314379 - Homo sapiens cDNA, FLJ95152.
AB037755 - Homo sapiens KIAA1334 mRNA for KIAA1334 protein.
AK308306 - Homo sapiens cDNA, FLJ98254.
BC028681 - Homo sapiens retinoic acid induced 14, mRNA (cDNA clone IMAGE:4822221), with apparent retained intron.
AY317139 - Homo sapiens RAI14 isoform mRNA, complete cds.
AB384179 - Synthetic construct DNA, clone: pF1KSDA1334, Homo sapiens RAI14 gene for ankycorbin, complete cds, without stop codon, in Flexi system.
KJ898589 - Synthetic construct Homo sapiens clone ccsbBroadEn_07983 RAI14 gene, encodes complete protein.
AY354204 - Homo sapiens retinoic acid induced 14 isoform (RAI14) mRNA, complete cds, alternatively spliced.
AK297964 - Homo sapiens cDNA FLJ53145 partial cds, highly similar to Ankycorbin.
AK308455 - Homo sapiens cDNA, FLJ98403.
DQ571107 - Homo sapiens piRNA piR-31219, complete sequence.
AL050011 - Homo sapiens mRNA; cDNA DKFZp564G013 (from clone DKFZp564G013).
AK023135 - Homo sapiens cDNA FLJ13073 fis, clone NT2RP3001854, highly similar to Ankycorbin.
DQ577528 - Homo sapiens piRNA piR-45640, complete sequence.
JD163815 - Sequence 144839 from Patent EP1572962.
JD250834 - Sequence 231858 from Patent EP1572962.
JD046171 - Sequence 27195 from Patent EP1572962.
JD226762 - Sequence 207786 from Patent EP1572962.
JD456106 - Sequence 437130 from Patent EP1572962.
JD354185 - Sequence 335209 from Patent EP1572962.
JD484674 - Sequence 465698 from Patent EP1572962.
JD398853 - Sequence 379877 from Patent EP1572962.
JD398854 - Sequence 379878 from Patent EP1572962.
JD375564 - Sequence 356588 from Patent EP1572962.
JD357899 - Sequence 338923 from Patent EP1572962.
JD324037 - Sequence 305061 from Patent EP1572962.
JD094540 - Sequence 75564 from Patent EP1572962.
JD553050 - Sequence 534074 from Patent EP1572962.
JD550152 - Sequence 531176 from Patent EP1572962.
JD093325 - Sequence 74349 from Patent EP1572962.
JD242147 - Sequence 223171 from Patent EP1572962.
JD217124 - Sequence 198148 from Patent EP1572962.
JD108651 - Sequence 89675 from Patent EP1572962.
JD251975 - Sequence 232999 from Patent EP1572962.
JD019087 - Sequence 111 from Patent EP1572962.
JD128350 - Sequence 109374 from Patent EP1572962.
JD207185 - Sequence 188209 from Patent EP1572962.
JD243049 - Sequence 224073 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: E9PED3, ENST00000265109.1, ENST00000265109.2, ENST00000265109.3, ENST00000265109.4, ENST00000265109.5, ENST00000265109.6, ENST00000265109.7, KIAA1334, NM_015577, NORPEG, Q6V1W9, Q7Z5I4, Q7Z733, Q9P0K7, Q9P2L2, Q9Y3T5, RAI14_HUMAN, uc317hys.1, uc317hys.2
UCSC ID: ENST00000265109.8_7
RefSeq Accession: NM_015577.3
Protein: Q9P0K7 (aka RAI14_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.