Human Gene RADIL (ENST00000399583.4_7) from GENCODE V47lift37

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Description: Rap associating with DIL domain (from RefSeq NM_018059.5)
Gencode Transcript: ENST00000399583.4_7
Gencode Gene: ENSG00000157927.17_11
Transcript (Including UTRs)
Position: hg19 chr7:4,836,686-4,923,347 Size: 86,662 Total Exon Count: 15 Strand: -
Coding Region
Position: hg19 chr7:4,839,009-4,917,770 Size: 78,762 Coding Exon Count: 14

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr7:4,836,686-4,923,347)			mRNA (may differ from genome)		Protein (1075 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: RADIL_HUMAN DESCRIPTION: RecName: Full=Ras-associating and dilute domain-containing protein; FUNCTION: Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. SUBUNIT: Interacts with RAP1A; in a GTP-dependent manner. Does not interact with members of the Ras family. INTERACTION: P31939:ATIC; NbExp=1; IntAct=EBI-744267, EBI-1048599; P51946:CCNH; NbExp=1; IntAct=EBI-744267, EBI-741406; P24941:CDK2; NbExp=1; IntAct=EBI-744267, EBI-375096; O75771:RAD51L3; NbExp=1; IntAct=EBI-744267, EBI-1055693; SIMILARITY: Belongs to the RADIL family. SIMILARITY: Contains 1 dilute domain. SIMILARITY: Contains 1 FHA domain. SIMILARITY: Contains 1 PDZ (DHR) domain. SIMILARITY: Contains 1 Ras-associating domain. SEQUENCE CAUTION: Sequence=AAS07559.1; Type=Erroneous gene model prediction; Sequence=BAA91543.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB47478.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine D002251 Carbon Tetrachloride D002737 Chloroprene D004997 Ethinyl Estradiol D014212 Tretinoin C006253 pirinixic acid C025643 vinclozolin

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 9.15 RPKM in Testis Total median expression: 93.05 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-87.90	185	-0.475	Picture	PostScript	Text
3' UTR	-945.50	2323	-0.407	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR018444 - Dil_domain
IPR002710 - Dilute
IPR000253 - FHA_dom
IPR001478 - PDZ
IPR000159 - Ras-assoc
IPR008984 - SMAD_FHA_domain

Pfam Domains:
PF00595 - PDZ domain
PF00788 - Ras association (RalGDS/AF-6) domain
PF01843 - DIL domain
PF17820 - PDZ domain

SCOP Domains:
49879 - SMAD/FHA domain
50156 - PDZ domain-like
54236 - Ubiquitin-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1UM1 - NMR MuPIT

3EC8 - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q96JH8


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding Biological Process: GO:0007155 cell adhesion GO:0007165 signal transduction GO:0007275 multicellular organism development GO:0034446 substrate adhesion-dependent cell spreading Cellular Component: GO:0005874 microtubule

Descriptions from all associated GenBank mRNAs


	AB058752 - Homo sapiens KIAA1849 mRNA for KIAA1849 protein. AK000997 - Homo sapiens cDNA FLJ10135 fis, clone HEMBA1003117. AK001186 - Homo sapiens cDNA FLJ10324 fis, clone NT2RM2000567. EF560723 - Homo sapiens clone DKFZp434C074 FLJ10324 protein (FLJ10324) mRNA, complete cds. AK294745 - Homo sapiens cDNA FLJ50093 complete cds. AK302549 - Homo sapiens cDNA FLJ60975 complete cds. AL136731 - Homo sapiens mRNA; cDNA DKFZp434H2410 (from clone DKFZp434H2410). AK296325 - Homo sapiens cDNA FLJ59554 complete cds. BC143526 - Homo sapiens Ras association and DIL domains, mRNA (cDNA clone MGC:177052 IMAGE:9052035), complete cds. BC126311 - Homo sapiens Ras association and DIL domains, mRNA (cDNA clone MGC:161589 IMAGE:8992027), complete cds. BC117317 - Homo sapiens Ras association and DIL domains, mRNA (cDNA clone MGC:150926 IMAGE:40125868), complete cds. AB527399 - Synthetic construct DNA, clone: pF1KA1849, Homo sapiens RADIL gene for Ras association and DIL domains, without stop codon, in Flexi system. BC004919 - Homo sapiens Ras association and DIL domains, mRNA (cDNA clone IMAGE:3543951), complete cds. JD316963 - Sequence 297987 from Patent EP1572962. JD413174 - Sequence 394198 from Patent EP1572962. JD459828 - Sequence 440852 from Patent EP1572962. JD226630 - Sequence 207654 from Patent EP1572962. JD059212 - Sequence 40236 from Patent EP1572962. JD365864 - Sequence 346888 from Patent EP1572962. JD210625 - Sequence 191649 from Patent EP1572962. KJ906239 - Synthetic construct Homo sapiens clone ccsbBroadEn_15909 RADIL gene, encodes complete protein. CU678808 - Synthetic construct Homo sapiens gateway clone IMAGE:100017117 5' read FLJ10324 mRNA. JD322778 - Sequence 303802 from Patent EP1572962. JD215915 - Sequence 196939 from Patent EP1572962. JD485060 - Sequence 466084 from Patent EP1572962. JD393446 - Sequence 374470 from Patent EP1572962. JD408719 - Sequence 389743 from Patent EP1572962. JD546485 - Sequence 527509 from Patent EP1572962. JD482904 - Sequence 463928 from Patent EP1572962. JD129644 - Sequence 110668 from Patent EP1572962. JD417480 - Sequence 398504 from Patent EP1572962. JD389272 - Sequence 370296 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A4D1Z5, A5YM49, B7ZL20, ENST00000399583.1, ENST00000399583.2, ENST00000399583.3, KIAA1849, NM_018059, Q0VFZ9, Q75LH3, Q96JH8, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4, RADIL_HUMAN, uc319akm.1, uc319akm.2 UCSC ID: ENST00000399583.4_7 RefSeq Accession: NM_018059.5 Protein: Q96JH8 (aka RADIL_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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