Human Gene RAB2B (ENST00000397762.6_7) from GENCODE V47lift37
  Description: RAB2B, member RAS oncogene family, transcript variant 3 (from RefSeq NR_028074.2)
Gencode Transcript: ENST00000397762.6_7
Gencode Gene: ENSG00000129472.15_10
Transcript (Including UTRs)
   Position: hg19 chr14:21,927,179-21,945,118 Size: 17,940 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr14:21,929,355-21,945,031 Size: 15,677 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:21,927,179-21,945,118)mRNA (may differ from genome)Protein (216 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RAB2B_HUMAN
DESCRIPTION: RecName: Full=Ras-related protein Rab-2B;
FUNCTION: Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential).
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Endoplasmic reticulum membrane (Potential). Golgi apparatus membrane (Potential).
TISSUE SPECIFICITY: Expressed in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and low levels in placenta. Not detected in heart, brain, spleen, testis, ovary, small intestine and leukocyte.
SIMILARITY: Belongs to the small GTPase superfamily. Rab family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.71 RPKM in Thyroid
Total median expression: 435.89 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -16.4087-0.189 Picture PostScript Text
3' UTR -760.002176-0.349 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR001806 - Small_GTPase
IPR003579 - Small_GTPase_Rab_type

Pfam Domains:
PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF01926 - 50S ribosome-binding GTPase
PF04670 - Gtr1/RagA G protein conserved region
PF08477 - Ras of Complex, Roc, domain of DAPkinase

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2A5J - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q8WUD1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding

Biological Process:
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0045921 positive regulation of exocytosis

Cellular Component:
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular exosome
GO:0098793 presynapse


-  Descriptions from all associated GenBank mRNAs
  BC066366 - Homo sapiens RAB2B, member RAS oncogene family, mRNA (cDNA clone MGC:61822 IMAGE:6618093), complete cds.
AK027730 - Homo sapiens cDNA FLJ14824 fis, clone OVARC1000771, moderately similar to RAS-RELATED PROTEIN RAB-2.
BC020839 - Homo sapiens RAB2B, member RAS oncogene family, mRNA (cDNA clone MGC:23955 IMAGE:4306410), complete cds.
AF468652 - Homo sapiens RAB2B mRNA, complete cds.
BX647601 - Homo sapiens mRNA; cDNA DKFZp313C1541 (from clone DKFZp313C1541).
JD113606 - Sequence 94630 from Patent EP1572962.
JD528734 - Sequence 509758 from Patent EP1572962.
JD313502 - Sequence 294526 from Patent EP1572962.
JD537076 - Sequence 518100 from Patent EP1572962.
JD190620 - Sequence 171644 from Patent EP1572962.
JD349546 - Sequence 330570 from Patent EP1572962.
JD375786 - Sequence 356810 from Patent EP1572962.
JD051735 - Sequence 32759 from Patent EP1572962.
JD554776 - Sequence 535800 from Patent EP1572962.
JD082845 - Sequence 63869 from Patent EP1572962.
JD109696 - Sequence 90720 from Patent EP1572962.
JD454247 - Sequence 435271 from Patent EP1572962.
JD236433 - Sequence 217457 from Patent EP1572962.
JD062649 - Sequence 43673 from Patent EP1572962.
JD506990 - Sequence 488014 from Patent EP1572962.
AK296057 - Homo sapiens cDNA FLJ55078 complete cds, highly similar to Ras-related protein Rab-2B.
JD311792 - Sequence 292816 from Patent EP1572962.
JD304119 - Sequence 285143 from Patent EP1572962.
JD304120 - Sequence 285144 from Patent EP1572962.
JD054559 - Sequence 35583 from Patent EP1572962.
JD397048 - Sequence 378072 from Patent EP1572962.
JD311791 - Sequence 292815 from Patent EP1572962.
JD142461 - Sequence 123485 from Patent EP1572962.
JD256541 - Sequence 237565 from Patent EP1572962.
JD379669 - Sequence 360693 from Patent EP1572962.
JD148683 - Sequence 129707 from Patent EP1572962.
JD379667 - Sequence 360691 from Patent EP1572962.
JD120558 - Sequence 101582 from Patent EP1572962.
JD120559 - Sequence 101583 from Patent EP1572962.
JD414809 - Sequence 395833 from Patent EP1572962.
JD560690 - Sequence 541714 from Patent EP1572962.
JD396171 - Sequence 377195 from Patent EP1572962.
JD489077 - Sequence 470101 from Patent EP1572962.
JD409265 - Sequence 390289 from Patent EP1572962.
JD489076 - Sequence 470100 from Patent EP1572962.
JD374523 - Sequence 355547 from Patent EP1572962.
AK300599 - Homo sapiens cDNA FLJ59988 complete cds, highly similar to Ras-related protein Rab-2B.
AK307349 - Homo sapiens cDNA, FLJ97297.
JD329242 - Sequence 310266 from Patent EP1572962.
JD556784 - Sequence 537808 from Patent EP1572962.
AK315354 - Homo sapiens cDNA, FLJ96399, Homo sapiens RAB2B, member RAS oncogene family (RAB2B), mRNA.
KJ900881 - Synthetic construct Homo sapiens clone ccsbBroadEn_10275 RAB2B gene, encodes complete protein.
CU676744 - Synthetic construct Homo sapiens gateway clone IMAGE:100022153 5' read RAB2B mRNA.
KJ895054 - Synthetic construct Homo sapiens clone ccsbBroadEn_04448 RAB2B gene, encodes complete protein.
DQ893243 - Synthetic construct clone IMAGE:100005873; FLH195548.01X; RZPDo839D08152D RAB2B, member RAS oncogene family (RAB2B) gene, encodes complete protein.
DQ896572 - Synthetic construct Homo sapiens clone IMAGE:100011032; FLH195544.01L; RZPDo839D08151D RAB2B, member RAS oncogene family (RAB2B) gene, encodes complete protein.
CU688158 - Synthetic construct Homo sapiens gateway clone IMAGE:100022340 5' read RAB2B mRNA.
AF091029 - Homo sapiens GTP-binding protein RAB2B (RAB2B) mRNA, partial cds.
JD439729 - Sequence 420753 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8WUD1 (Reactome details) participates in the following event(s):

R-HSA-8870466 RGGT:CHM binds RABs
R-HSA-8870469 RGGT geranylgeranylates RAB proteins
R-HSA-8873719 RAB geranylgeranylation
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: B2RD03, D3DS24, ENST00000397762.1, ENST00000397762.2, ENST00000397762.3, ENST00000397762.4, ENST00000397762.5, NR_028074, Q6NZ33, Q8WUD1, RAB2B , RAB2B_HUMAN, uc318zgo.1, uc318zgo.2
UCSC ID: ENST00000397762.6_7
RefSeq Accession: NM_032846.4
Protein: Q8WUD1 (aka RAB2B_HUMAN or RB2B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.