Human Gene RAB19 (ENST00000356407.3_2) from GENCODE V47lift37
  Description: RAB19, member RAS oncogene family (from HGNC RAB19)
Gencode Transcript: ENST00000356407.3_2
Gencode Gene: ENSG00000146955.11_9
Transcript (Including UTRs)
   Position: hg19 chr7:140,107,379-140,126,050 Size: 18,672 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr7:140,107,447-140,125,950 Size: 18,504 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:140,107,379-140,126,050)mRNA (may differ from genome)Protein (217 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MGIPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: C9JJQ5_HUMAN
DESCRIPTION: SubName: Full=Ras-related protein Rab-19; Flags: Fragment;
SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.11 RPKM in Pituitary
Total median expression: 6.34 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -16.0068-0.235 Picture PostScript Text
3' UTR -23.70100-0.237 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR001806 - Small_GTPase
IPR003579 - Small_GTPase_Rab_type

Pfam Domains:
PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF08477 - Ras of Complex, Roc, domain of DAPkinase

SCOP Domains:
51735 - NAD(P)-binding Rossmann-fold domains
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on C9JJQ5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003924 GTPase activity
GO:0005525 GTP binding


-  Descriptions from all associated GenBank mRNAs
  BC140796 - Homo sapiens RAB19, member RAS oncogene family, mRNA (cDNA clone MGC:176473 IMAGE:9021664), complete cds.
BC171745 - Homo sapiens cDNA clone IMAGE:9053100.
KJ900737 - Synthetic construct Homo sapiens clone ccsbBroadEn_10131 RAB19-like gene, encodes complete protein.
JD221534 - Sequence 202558 from Patent EP1572962.
AF091033 - Homo sapiens GTP-binding protein RAB19B (RAB19B) mRNA, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: BC140796, C9JJQ5, ENST00000356407.1, ENST00000356407.2, uc317znq.1, uc317znq.2
UCSC ID: ENST00000356407.3_2
RefSeq Accession: NM_001008749.3
Protein: C9JJQ5

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.