ID:RAB13_HUMAN DESCRIPTION: RecName: Full=Ras-related protein Rab-13; AltName: Full=Cell growth-inhibiting gene 4 protein; Flags: Precursor; FUNCTION: Could participate in polarized transport, in the assembly and/or the activity of tight junctions. SUBUNIT: Interacts with CCDC64B/BICDR2 (By similarity). SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Note=Cytoplasmic tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions. TISSUE SPECIFICITY: Detected in several types of epithelia, including intestine, kidney, liver and in endothelial cells. SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00025 - ADP-ribosylation factor family PF00071 - Ras family PF01926 - 50S ribosome-binding GTPase PF04670 - Gtr1/RagA G protein conserved region PF08477 - Ras of Complex, Roc, domain of DAPkinase PF09439 - Signal recognition particle receptor beta subunit
ModBase Predicted Comparative 3D Structure on P51153
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0010737 protein kinase A signaling GO:0015031 protein transport GO:0016197 endosomal transport GO:0030866 cortical actin cytoskeleton organization GO:0031175 neuron projection development GO:0032456 endocytic recycling GO:0032869 cellular response to insulin stimulus GO:0035767 endothelial cell chemotaxis GO:0043687 post-translational protein modification GO:0044795 trans-Golgi network to recycling endosome transport GO:0070830 bicellular tight junction assembly GO:0072659 protein localization to plasma membrane GO:0097368 establishment of Sertoli cell barrier GO:1902463 protein localization to cell leading edge
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
