Human Gene RAB11B (ENST00000328024.11_4) from GENCODE V47lift37

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Description: RAB11B, member RAS oncogene family (from RefSeq NM_004218.4)
Gencode Transcript: ENST00000328024.11_4
Gencode Gene: ENSG00000185236.12_8
Transcript (Including UTRs)
Position: hg19 chr19:8,455,244-8,469,318 Size: 14,075 Total Exon Count: 5 Strand: +
Coding Region
Position: hg19 chr19:8,455,301-8,468,442 Size: 13,142 Coding Exon Count: 5

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:8,455,244-8,469,318)			mRNA (may differ from genome)		Protein (218 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: RB11B_HUMAN DESCRIPTION: RecName: Full=Ras-related protein Rab-11B; AltName: Full=GTP-binding protein YPT3; Flags: Precursor; FUNCTION: GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity). SUBUNIT: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). SIMILARITY: Belongs to the small GTPase superfamily. Rab family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: RAB11B Diseases sorted by gene-association score: hypotrichosis 3 (3), rectum adenocarcinoma (3), cystic fibrosis (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl D000082 Acetaminophen D000535 Aluminum D000643 Ammonium Chloride D002995 Clofibric Acid D003993 Dibutyl Phthalate D004052 Diethylnitrosamine D019833 Genistein D009020 Morphine D010042 Ouabain more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 132.97 RPKM in Thyroid Total median expression: 3142.26 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-33.70	57	-0.591	Picture	PostScript	Text
3' UTR	-321.90	876	-0.367	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR001806 - Small_GTPase
IPR003579 - Small_GTPase_Rab_type

Pfam Domains:
PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF01926 - 50S ribosome-binding GTPase
PF08477 - Ras of Complex, Roc, domain of DAPkinase

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases
53795 - PEP carboxykinase-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2F9L - X-ray MuPIT

2F9M - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q15907


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser
Gene Details	Gene Details				Gene Details
Gene Sorter	Gene Sorter				Gene Sorter
	RGD	Ensembl			SGD
					Protein Sequence
					Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000166 nucleotide binding GO:0003924 GTPase activity GO:0005515 protein binding GO:0005525 GTP binding GO:0019003 GDP binding GO:0031489 myosin V binding GO:0045296 cadherin binding Biological Process: GO:0001881 receptor recycling GO:0015031 protein transport GO:0032402 melanosome transport GO:0033572 transferrin transport GO:0035773 insulin secretion involved in cellular response to glucose stimulus GO:0043687 post-translational protein modification GO:0044070 regulation of anion transport GO:0045054 constitutive secretory pathway GO:0045055 regulated exocytosis GO:0045056 transcytosis GO:0071468 cellular response to acidic pH GO:0090150 establishment of protein localization to membrane GO:1990126 retrograde transport, endosome to plasma membrane GO:2000008 regulation of protein localization to cell surface GO:2001135 regulation of endocytic recycling Cellular Component: GO:0005737 cytoplasm GO:0005768 endosome GO:0005829 cytosol GO:0008021 synaptic vesicle GO:0016020 membrane GO:0030054 cell junction GO:0030670 phagocytic vesicle membrane GO:0030672 synaptic vesicle membrane GO:0031410 cytoplasmic vesicle GO:0045202 synapse GO:0045335 phagocytic vesicle GO:0055037 recycling endosome GO:0055038 recycling endosome membrane GO:0070062 extracellular exosome GO:0098993 anchored component of synaptic vesicle membrane

Descriptions from all associated GenBank mRNAs


	LF385185 - JP 2014500723-A/192688: Polycomb-Associated Non-Coding RNAs. AK310573 - Homo sapiens cDNA, FLJ17615. EF560724 - Homo sapiens clone DKFZp564C1023 RAB11B protein (RAB11B) mRNA, complete cds. AK312994 - Homo sapiens cDNA, FLJ93455, highly similar to Homo sapiens RAB11B, member RAS oncogene family (RAB11B), mRNA. AK297498 - Homo sapiens cDNA FLJ61134 complete cds, highly similar to Ras-related protein Rab-11B. BX647356 - Homo sapiens mRNA; cDNA DKFZp686E23256 (from clone DKFZp686E23256). AK225642 - Homo sapiens mRNA for RAB11B, member RAS oncogene family variant, clone: SPL07754. AK225036 - Homo sapiens mRNA for RAB11B, member RAS oncogene family variant, clone: adKA03145. D38516 - Homo sapiens Rab11B mRNA. X79780 - H.sapiens YPT3 mRNA. BC110081 - Homo sapiens RAB11B, member RAS oncogene family, mRNA (cDNA clone MGC:133246 IMAGE:40035112), complete cds. AB590872 - Synthetic construct DNA, clone: pFN21AE1715, Homo sapiens RAB11B gene for RAB11B, member RAS oncogene family, without stop codon, in Flexi system. CR541691 - Homo sapiens full open reading frame cDNA clone RZPDo834D1128D for gene RAB11B, RAB11B, member RAS oncogene family; complete cds, without stopcodon. BT019535 - Homo sapiens RAB11B, member RAS oncogene family mRNA, complete cds. BT019536 - Homo sapiens RAB11B, member RAS oncogene family mRNA, complete cds. KJ897984 - Synthetic construct Homo sapiens clone ccsbBroadEn_07378 RAB11B gene, encodes complete protein. GQ129216 - Synthetic construct Homo sapiens clone HAIB:100068640; DKFZo004A0136 RAB11B, member RAS oncogene family protein (RAB11B) gene, partial cds. AF498947 - Homo sapiens small GTP binding protein RAB11B (RAB11B) mRNA, complete cds. CR536494 - Homo sapiens full open reading frame cDNA clone RZPDo834G1017D for gene RAB11B, RAB11B, member RAS oncogene family; complete cds, incl. stopcodon. GQ129215 - Synthetic construct Homo sapiens clone HAIB:100068544; DKFZo008A0135 RAB11B, member RAS oncogene family protein (RAB11B) gene, complete cds. LF211221 - JP 2014500723-A/18724: Polycomb-Associated Non-Coding RNAs. LF211219 - JP 2014500723-A/18722: Polycomb-Associated Non-Coding RNAs. LF341188 - JP 2014500723-A/148691: Polycomb-Associated Non-Coding RNAs. LF344660 - JP 2014500723-A/152163: Polycomb-Associated Non-Coding RNAs. LF341185 - JP 2014500723-A/148688: Polycomb-Associated Non-Coding RNAs. LF341184 - JP 2014500723-A/148687: Polycomb-Associated Non-Coding RNAs. LF344659 - JP 2014500723-A/152162: Polycomb-Associated Non-Coding RNAs. LF341181 - JP 2014500723-A/148684: Polycomb-Associated Non-Coding RNAs. LF344658 - JP 2014500723-A/152161: Polycomb-Associated Non-Coding RNAs. LF341178 - JP 2014500723-A/148681: Polycomb-Associated Non-Coding RNAs. LF344657 - JP 2014500723-A/152160: Polycomb-Associated Non-Coding RNAs. LF205516 - JP 2014500723-A/13019: Polycomb-Associated Non-Coding RNAs. JD479102 - Sequence 460126 from Patent EP1572962. LF321422 - JP 2014500723-A/128925: Polycomb-Associated Non-Coding RNAs. LF341177 - JP 2014500723-A/148680: Polycomb-Associated Non-Coding RNAs. JD457079 - Sequence 438103 from Patent EP1572962. LF341176 - JP 2014500723-A/148679: Polycomb-Associated Non-Coding RNAs. LF321423 - JP 2014500723-A/128926: Polycomb-Associated Non-Coding RNAs. LF344656 - JP 2014500723-A/152159: Polycomb-Associated Non-Coding RNAs. JD178330 - Sequence 159354 from Patent EP1572962. LF341175 - JP 2014500723-A/148678: Polycomb-Associated Non-Coding RNAs. LF321424 - JP 2014500723-A/128927: Polycomb-Associated Non-Coding RNAs. LF344655 - JP 2014500723-A/152158: Polycomb-Associated Non-Coding RNAs. JD125888 - Sequence 106912 from Patent EP1572962. JD519913 - Sequence 500937 from Patent EP1572962. MA620762 - JP 2018138019-A/192688: Polycomb-Associated Non-Coding RNAs. MA580237 - JP 2018138019-A/152163: Polycomb-Associated Non-Coding RNAs. MA580236 - JP 2018138019-A/152162: Polycomb-Associated Non-Coding RNAs. MA580235 - JP 2018138019-A/152161: Polycomb-Associated Non-Coding RNAs. MA580234 - JP 2018138019-A/152160: Polycomb-Associated Non-Coding RNAs. MA556999 - JP 2018138019-A/128925: Polycomb-Associated Non-Coding RNAs. MA557000 - JP 2018138019-A/128926: Polycomb-Associated Non-Coding RNAs. MA580233 - JP 2018138019-A/152159: Polycomb-Associated Non-Coding RNAs. MA557001 - JP 2018138019-A/128927: Polycomb-Associated Non-Coding RNAs. MA580232 - JP 2018138019-A/152158: Polycomb-Associated Non-Coding RNAs. MA446798 - JP 2018138019-A/18724: Polycomb-Associated Non-Coding RNAs. MA446796 - JP 2018138019-A/18722: Polycomb-Associated Non-Coding RNAs. MA576765 - JP 2018138019-A/148691: Polycomb-Associated Non-Coding RNAs. MA576762 - JP 2018138019-A/148688: Polycomb-Associated Non-Coding RNAs. MA576761 - JP 2018138019-A/148687: Polycomb-Associated Non-Coding RNAs. MA576758 - JP 2018138019-A/148684: Polycomb-Associated Non-Coding RNAs. MA576755 - JP 2018138019-A/148681: Polycomb-Associated Non-Coding RNAs. MA441093 - JP 2018138019-A/13019: Polycomb-Associated Non-Coding RNAs. MA576754 - JP 2018138019-A/148680: Polycomb-Associated Non-Coding RNAs. MA576753 - JP 2018138019-A/148679: Polycomb-Associated Non-Coding RNAs. MA576752 - JP 2018138019-A/148678: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q15907 (Reactome details) participates in the following event(s): R-HSA-8854759 TBC1D14 binds RAB11 and ULK1 R-HSA-8870466 RGGT:CHM binds RABs R-HSA-8870469 RGGT geranylgeranylates RAB proteins R-HSA-8854214 TBC/RABGAPs R-HSA-9007101 Rab regulation of trafficking R-HSA-8873719 RAB geranylgeranylation R-HSA-199991 Membrane Trafficking R-HSA-597592 Post-translational protein modification R-HSA-5653656 Vesicle-mediated transport R-HSA-392499 Metabolism of proteins

Other Names for This Gene


	Alternate Gene Symbols: A5YM50, B2R7I4, B4DMK0, D6W671, ENST00000328024.1, ENST00000328024.10, ENST00000328024.2, ENST00000328024.3, ENST00000328024.4, ENST00000328024.5, ENST00000328024.6, ENST00000328024.7, ENST00000328024.8, ENST00000328024.9, NM_004218, Q15907, Q2YDT2, Q5U0I1, Q6FHR0, Q6FI42, Q8NI07, RB11B_HUMAN, uc317ski.1, uc317ski.2, YPT3 UCSC ID: ENST00000328024.11_4 RefSeq Accession: NM_004218.4 Protein: Q15907 (aka RB11B_HUMAN or R11B_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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