ID:P5CR2_HUMAN DESCRIPTION: RecName: Full=Pyrroline-5-carboxylate reductase 2; Short=P5C reductase 2; Short=P5CR 2; EC=1.5.1.2; FUNCTION: Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH. CATALYTIC ACTIVITY: L-proline + NAD(P)(+) = 1-pyrroline-5- carboxylate + NAD(P)H. ENZYME REGULATION: Subject to competitive inhibition by NADP. Not inhibited by proline. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.64 mM for NADH; KM=0.04 mM for NADPH; KM=1.49 mM for pyrroline-5-carboxylate (in the presence of NADH); KM=0.23 mM for pyrroline-5-carboxylate (in the presence of NADPH); Vmax=28.5 umol/min/ug enzyme (in the presence of NADH); Vmax=3.7 umol/min/ug enzyme (in the presence of NADPH); PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L- proline from L-glutamate 5-semialdehyde: step 1/1. SUBUNIT: Homodecamer; composed of 5 homodimers (Probable). SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Detected in erythrocytes (at protein level). SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96C36
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006561 proline biosynthetic process GO:0008652 cellular amino acid biosynthetic process GO:0034599 cellular response to oxidative stress GO:0055114 oxidation-reduction process GO:0055129 L-proline biosynthetic process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
