Human Gene PURB (ENST00000395699.5_7) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: PURB_HUMAN
DESCRIPTION: RecName: Full=Transcriptional activator protein Pur-beta; AltName: Full=Purine-rich element-binding protein B;
FUNCTION: Has capacity to bind repeated elements in single- stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine- rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity).
SUBUNIT: Homodimer, heterodimer with PURA and heterotrimer with PURA and YBX1/Y-box protein 1 (By similarity).
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed in myocardium of heart failure patients.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity).
MISCELLANEOUS: Defects in PURB may be a cause of progression of myelodysplastic syndrome (MDS) towards acute myelogenous leukemia (AML). MDS refers to a heterogeneous group of closely related hematopoietic disorders. All are characterized by a cellular marrow with impaired morphology and maturation (dysmyelopoiesis) and peripheral blood cytopenias, resulting from ineffective blood cell production. Some patients with MDS develop acute myelogenous leukemia (AML), a malignant disease in which hematopoietic precursors are arrested in an early stage of development.
SIMILARITY: Belongs to the PUR DNA-binding protein family.
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Primer design for this transcript
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MalaCards Disease Associations
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Comparative Toxicogenomics Database (CTD)
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 Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure
IPR006628 - PUR_DNA_RNA-bd
Pfam Domains:
PF04845 - PurA ssDNA and RNA-binding protein
ModBase Predicted Comparative 3D Structure on Q96QR8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Molecular Function:
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0008134 transcription factor binding
GO:0046332 SMAD binding
Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008283 cell proliferation
GO:0030154 cell differentiation
GO:0045637 regulation of myeloid cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component:
GO:0005634 nucleus
GO:0005662 DNA replication factor A complex
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Descriptions from all associated GenBank mRNAs
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KJ897429 - Synthetic construct Homo sapiens clone ccsbBroadEn_06823 PURB gene, encodes complete protein.
AK054977 - Homo sapiens cDNA FLJ30415 fis, clone BRACE2008706.
AK057669 - Homo sapiens cDNA FLJ33107 fis, clone TRACH2000959.
JD320961 - Sequence 301985 from Patent EP1572962.
JD439450 - Sequence 420474 from Patent EP1572962.
JD264310 - Sequence 245334 from Patent EP1572962.
JD557955 - Sequence 538979 from Patent EP1572962.
JD041212 - Sequence 22236 from Patent EP1572962.
JD169177 - Sequence 150201 from Patent EP1572962.
JD529105 - Sequence 510129 from Patent EP1572962.
JD557296 - Sequence 538320 from Patent EP1572962.
JD430123 - Sequence 411147 from Patent EP1572962.
JD169176 - Sequence 150200 from Patent EP1572962.
AK056651 - Homo sapiens cDNA FLJ32089 fis, clone OCBBF2000712.
DL492504 - Novel nucleic acids.
DL490973 - Novel nucleic acids.
JD027275 - Sequence 8299 from Patent EP1572962.
JD032935 - Sequence 13959 from Patent EP1572962.
JD030245 - Sequence 11269 from Patent EP1572962.
HZ409458 - JP 2015528002-A/2055: CHIRAL CONTROL.
LG052792 - KR 1020150036642-A/2058: CHIRAL CONTROL.
FR772892 - Homo sapiens microRNA hsa-miR-4657-5p.
HZ481770 - JP 2015535430-A/2276: TERMINALLY MODIFIED RNA.
HZ791701 - JP 2016504050-A/3446: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
JC514433 - Sequence 4686 from Patent WO2014113089.
LF161904 - JP 2016513950-A/1970: Oligomers with improved off-target profile.
LQ072021 - Sequence 2345 from Patent EP2964234.
DL491776 - Novel nucleic acids.
AY039216 - Homo sapiens Pur-beta (PURB) mRNA, complete cds.
JD243632 - Sequence 224656 from Patent EP1572962.
JD146511 - Sequence 127535 from Patent EP1572962.
JD385164 - Sequence 366188 from Patent EP1572962.
JD318171 - Sequence 299195 from Patent EP1572962.
JD505533 - Sequence 486557 from Patent EP1572962.
BC101735 - Homo sapiens purine-rich element binding protein B, mRNA (cDNA clone MGC:126784 IMAGE:8069241), complete cds.
BC101737 - Homo sapiens purine-rich element binding protein B, mRNA (cDNA clone MGC:126786 IMAGE:8069243), complete cds.
AB464680 - Synthetic construct DNA, clone: pF1KB9822, Homo sapiens PURB gene for purine-rich element binding protein B, without stop codon, in Flexi system.
DQ592912 - Homo sapiens piRNA piR-60024, complete sequence.
MA645522 - JP 2017113010-A/3446: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MA733406 - JP 2017140048-A/2276: TERMINALLY MODIFIED RNA.
MA802575 - JP 2018183181-A/3446: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
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Other Names for This Gene
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Alternate Gene Symbols: A4D2L7, ENST00000395699.1, ENST00000395699.2, ENST00000395699.3, ENST00000395699.4, NM_033224, PURB_HUMAN, Q96QR8, uc318xpx.1, uc318xpx.2
UCSC ID: ENST00000395699.5_7
RefSeq Accession: NM_033224.5
Protein: Q96QR8
(aka PURB_HUMAN)
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
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US Server
