ID:PTN_HUMAN DESCRIPTION: RecName: Full=Pleiotrophin; Short=PTN; AltName: Full=Heparin-binding brain mitogen; Short=HBBM; AltName: Full=Heparin-binding growth factor 8; Short=HBGF-8; AltName: Full=Heparin-binding growth-associated molecule; Short=HB-GAM; AltName: Full=Heparin-binding neurite outgrowth-promoting factor 1; Short=HBNF-1; AltName: Full=Osteoblast-specific factor 1; Short=OSF-1; Flags: Precursor; FUNCTION: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation. SUBUNIT: Interacts with ALK and NEK6. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Osteoblast and brain. INDUCTION: By heparin and retinoic acid. PTM: Phosphorylated by NEK6. SIMILARITY: Belongs to the pleiotrophin family. WEB RESOURCE: Name=Wikipedia; Note=Pleiotrophin entry; URL="http://en.wikipedia.org/wiki/Pleiotrophin";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P21246
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001503 ossification GO:0001889 liver development GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007399 nervous system development GO:0007420 brain development GO:0007507 heart development GO:0007612 learning GO:0008284 positive regulation of cell proliferation GO:0008360 regulation of cell shape GO:0010469 regulation of receptor activity GO:0010811 positive regulation of cell-substrate adhesion GO:0010976 positive regulation of neuron projection development GO:0014823 response to activity GO:0016525 negative regulation of angiogenesis GO:0021510 spinal cord development GO:0021549 cerebellum development GO:0021794 thalamus development GO:0030282 bone mineralization GO:0030324 lung development GO:0030336 negative regulation of cell migration GO:0030902 hindbrain development GO:0032355 response to estradiol GO:0032515 negative regulation of phosphoprotein phosphatase activity GO:0032570 response to progesterone GO:0034644 cellular response to UV GO:0036120 cellular response to platelet-derived growth factor stimulus GO:0042493 response to drug GO:0043065 positive regulation of apoptotic process GO:0044849 estrous cycle GO:0045446 endothelial cell differentiation GO:0045837 negative regulation of membrane potential GO:0050680 negative regulation of epithelial cell proliferation GO:0051781 positive regulation of cell division GO:0060041 retina development in camera-type eye GO:0060221 retinal rod cell differentiation GO:0060253 negative regulation of glial cell proliferation GO:0060291 long-term synaptic potentiation GO:0071305 cellular response to vitamin D GO:0071407 cellular response to organic cyclic compound GO:0071456 cellular response to hypoxia GO:0072201 negative regulation of mesenchymal cell proliferation GO:1904373 response to kainic acid GO:1904389 rod bipolar cell differentiation GO:1904391 response to ciliary neurotrophic factor GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering GO:1904397 negative regulation of neuromuscular junction development GO:1990089 response to nerve growth factor GO:2000347 positive regulation of hepatocyte proliferation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
