ID:HOP2_HUMAN DESCRIPTION: RecName: Full=Homologous-pairing protein 2 homolog; AltName: Full=Nuclear receptor coactivator GT198; AltName: Full=PSMC3-interacting protein; AltName: Full=Proteasome 26S ATPase subunit 3-interacting protein; AltName: Full=Tat-binding protein 1-interacting protein; Short=TBP-1-interacting protein; FUNCTION: Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1- promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors. SUBUNIT: Interacts with the DNA-binding domain of the nuclear receptors NR3C1/GR, ESR2/ER-beta, THRB and RXRA (By similarity). Forms a stable heterodimer with MND1. Interacts with PSMC3/TBP1. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Highly expressed in testis and colon. INDUCTION: Overexpressed in leiomyomas compared to myometrium. PTM: PTM: Phosphorylated by PKA, PKC and MAPK (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: Defects in PSMC3IP are the cause of ovarian dysgenesis type 3 (ODG3) [MIM:614324]. A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. SIMILARITY: Belongs to the HOP2 family. SEQUENCE CAUTION: Sequence=AAC41915.1; Type=Frameshift; Positions=174, 184;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 46589 - tRNA-binding arm 47175 - Cytochromes 46785 - "Winged helix" DNA-binding domain 47655 - STAT 51338 - Composite domain of metallo-dependent hydrolases 64593 - Intermediate filament protein, coiled coil region 57997 - Tropomyosin
ModBase Predicted Comparative 3D Structure on Q9P2W1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
