Human Gene PSG1 (ENST00000436291.7_7) from GENCODE V47lift37

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Description: pregnancy specific beta-1-glycoprotein 1, transcript variant 2 (from RefSeq NM_001184825.2)
Gencode Transcript: ENST00000436291.7_7
Gencode Gene: ENSG00000231924.10_17
Transcript (Including UTRs)
Position: hg19 chr19:43,370,616-43,383,865 Size: 13,250 Total Exon Count: 6 Strand: -
Coding Region
Position: hg19 chr19:43,371,286-43,383,733 Size: 12,448 Coding Exon Count: 6

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:43,370,616-43,383,865)			mRNA (may differ from genome)		Protein (419 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	OMIM	PubMed	Reactome	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: PSG1_HUMAN DESCRIPTION: RecName: Full=Pregnancy-specific beta-1-glycoprotein 1; Short=PS-beta-G-1; Short=PSBG-1; Short=Pregnancy-specific glycoprotein 1; AltName: Full=CD66 antigen-like family member F; AltName: Full=Fetal liver non-specific cross-reactive antigen 1/2; Short=FL-NCA-1/2; AltName: Full=PSG95; AltName: Full=Pregnancy-specific beta-1 glycoprotein C/D; Short=PS-beta-C/D; AltName: CD_antigen=CD66f; Flags: Precursor; SUBCELLULAR LOCATION: Secreted (Potential). DEVELOPMENTAL STAGE: PSBG are produced in high quantity during pregnancy. SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family. SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D002857 Chromium D015032 Zinc C045037 testosterone-3-carboxymethyloxime-bovine serum albumin conjugate

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 0.23 RPKM in Cells - Cultured fibroblasts Total median expression: 0.39 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-39.70	132	-0.301	Picture	PostScript	Text
3' UTR	-157.70	670	-0.235	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR003598 - Ig_sub2
IPR013106 - Ig_V-set

Pfam Domains:
PF07686 - Immunoglobulin V-set domain
PF13895 - Immunoglobulin domain
PF13927 - Immunoglobulin domain

SCOP Domains:
48726 - Immunoglobulin
49373 - Invasin/intimin cell-adhesion fragments
49299 - PKD domain

ModBase Predicted Comparative 3D Structure on P11464


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding Biological Process: GO:0007565 female pregnancy GO:0050900 leukocyte migration Cellular Component: GO:0005576 extracellular region

Descriptions from all associated GenBank mRNAs


	BT007413 - Homo sapiens pregnancy specific beta-1-glycoprotein 4 mRNA, complete cds. KJ901669 - Synthetic construct Homo sapiens clone ccsbBroadEn_11063 PSG4 gene, encodes complete protein. BC058285 - Homo sapiens pregnancy specific beta-1-glycoprotein 1, mRNA (cDNA clone MGC:61825 IMAGE:4770394), complete cds. AK056754 - Homo sapiens cDNA FLJ32192 fis, clone PLACE6002323. AK075079 - Homo sapiens cDNA FLJ90598 fis, clone PLACE1001295, highly similar to Human pregnancy-specific beta 1-glycoprotein 4 (PSG4) clone FL-64 mRNA. M20881 - Human pregnancy-specific beta-glycoprotein d mRNA, complete cds. AK075135 - Homo sapiens cDNA FLJ90654 fis, clone PLACE1004520, highly similar to Human pregnancy-specific beta-glycoprotein d mRNA. M33664 - Human pregnancy-specific glycoprotein-1a (PSG-1a) mRNA, complete cds. M17908 - Human pregnancy-specific beta-1-glycoprotein mRNA, complete cds. AK300206 - Homo sapiens cDNA FLJ52751 complete cds, highly similar to Pregnancy-specific beta-1-glycoprotein 1 precursor. M21822 - Human pregnancy-specific beta-1-glycoprotein mRNA, complete cds. M25385 - Human pregnancy-specific beta-1-glycoprotein/fetal liver non-specific cross-reactive antigen-2 (FL-NCA-2) mRNA, complete cds. JD352624 - Sequence 333648 from Patent EP1572962. JD315521 - Sequence 296545 from Patent EP1572962. JD547533 - Sequence 528557 from Patent EP1572962. JD197598 - Sequence 178622 from Patent EP1572962. AK311491 - Homo sapiens cDNA, FLJ18533. AM393198 - Synthetic construct Homo sapiens clone IMAGE:100002966 for hypothetical protein (PSG1 gene). AM393602 - Synthetic construct Homo sapiens clone IMAGE:100002964 for hypothetical protein (PSG1 gene). AM393645 - Synthetic construct Homo sapiens clone IMAGE:100002965 for hypothetical protein (PSG1 gene). KJ891911 - Synthetic construct Homo sapiens clone ccsbBroadEn_01305 PSG1 gene, encodes complete protein. AB528216 - Synthetic construct DNA, clone: pF1KE0481, Homo sapiens PSG1 gene for pregnancy specific beta-1-glycoprotein 1, without stop codon, in Flexi system. M20879 - Human pregnancy-specific beta-glycoprotein c mRNA, complete cds. M34715 - Human pregnancy-specific beta-1-glycoprotein mRNA PSG95, complete cds. BC022338 - Homo sapiens pregnancy specific beta-1-glycoprotein 1, mRNA (cDNA clone MGC:23694 IMAGE:4732357), complete cds. M33663 - Human pregnancy-specific glycoprotein-1d (PSG-1d) mRNA, complete cds. J04539 - Human pregnancy-specific beta-1-glycoprotein/fetal liver non-specific cross-reactive antigen (FL-NCA-1) mRNA, complete cds. M37397 - Human carcinoembryonic antigen mRNA, clone SG9. CR450329 - Homo sapiens full open reading frame cDNA clone RZPDo834H031D for gene PSG1, pregnancy specific beta-1-glycoprotein 1; complete cds; without stopcodon. AK300152 - Homo sapiens cDNA FLJ52749 complete cds, highly similar to Pregnancy-specific beta-1-glycoprotein 1 precursor. M17909 - Human pregnancy-specific beta-1-glycoprotein mRNA, 5' end. JD186232 - Sequence 167256 from Patent EP1572962. JD298620 - Sequence 279644 from Patent EP1572962. JD371733 - Sequence 352757 from Patent EP1572962. JD213487 - Sequence 194511 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein P11464 (Reactome details) participates in the following event(s): R-HSA-8870732 PSGs bind proteoglycans and TGF-beta1 R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-109582 Hemostasis

Other Names for This Gene


	Alternate Gene Symbols: B1G1, ENST00000436291.1, ENST00000436291.2, ENST00000436291.3, ENST00000436291.4, ENST00000436291.5, ENST00000436291.6, NM_001184825, O75236, P11462, P11463, P11464, PSBG1, PSG1_HUMAN, PSGGA, Q15231, Q15241, Q15243, Q16660, Q6ICR4, Q9P1W5, Q9UQ79, uc320eqy.1, uc320eqy.2 UCSC ID: ENST00000436291.7_7 RefSeq Accession: NM_001184825.2 Protein: P11464 (aka PSG1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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