Human Gene PRR4 (ENST00000228811.8_10) from GENCODE V47lift37
  Description: proline rich 4, transcript variant 2 (from RefSeq NM_007244.3)
Gencode Transcript: ENST00000228811.8_10
Gencode Gene: ENSG00000111215.12_11
Transcript (Including UTRs)
   Position: hg19 chr12:10,998,448-11,002,074 Size: 3,627 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr12:10,999,662-11,002,036 Size: 2,375 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:10,998,448-11,002,074)mRNA (may differ from genome)Protein (134 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PROL4_HUMAN
DESCRIPTION: RecName: Full=Proline-rich protein 4; AltName: Full=Lacrimal proline-rich protein; AltName: Full=Nasopharyngeal carcinoma-associated proline-rich protein 4; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Abundantly expressed in lacrimal gland where it is found in the acinar cells but not in the intralobular ducts. Also found in the submandibular gland, the parotid and sublingual glands.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PRR4
Diseases sorted by gene-association score: ectodermal dysplasia-syndactyly syndrome 1* (354), dry eye syndrome (4), lacrimal apparatus disease (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 336.14 RPKM in Minor Salivary Gland
Total median expression: 403.11 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.3038-0.192 Picture PostScript Text
3' UTR -11.40120-0.095 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026086 - Pro-rich

Pfam Domains:
PF15240 - Proline-rich protein

ModBase Predicted Comparative 3D Structure on Q16378
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0001895 retina homeostasis
GO:0007601 visual perception

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  LP895862 - Sequence 726 from Patent EP3253886.
BC071692 - Homo sapiens cDNA clone IMAGE:5208808, **** WARNING: chimeric clone ****.
AB593030 - Homo sapiens PRH1 mRNA for hypothetical protein, complete cds, clone: HP04634-RBdS083D14.
AF530472 - Homo sapiens nasopharyngeal carcinoma-associated proline rich 4 (PROL4) mRNA, complete cds.
BX537839 - Homo sapiens mRNA; cDNA DKFZp779L1763 (from clone DKFZp779L1763).
AK292991 - Homo sapiens cDNA FLJ77668 complete cds, highly similar to Homo sapiens proline rich 4 (lacrimal) (PRR4), mRNA.
BC058035 - Homo sapiens proline rich 4 (lacrimal), mRNA (cDNA clone MGC:61943 IMAGE:6558043), complete cds.
AK292934 - Homo sapiens cDNA FLJ75036 complete cds, highly similar to Homo sapiens proline rich 4 (lacrimal) (PRR4), mRNA.
AK304321 - Homo sapiens cDNA FLJ54977 complete cds, weakly similar to Proline-rich protein 4 precursor.
S79048 - LPRP=pHL E1F1 [human, lacrimal gland, mRNA Partial, 507 nt].
JD085963 - Sequence 66987 from Patent EP1572962.
KJ898397 - Synthetic construct Homo sapiens clone ccsbBroadEn_07791 PRR4 gene, encodes complete protein.
AK311715 - Homo sapiens cDNA, FLJ18757.
JD286924 - Sequence 267948 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8KA69, ENST00000228811.1, ENST00000228811.2, ENST00000228811.3, ENST00000228811.4, ENST00000228811.5, ENST00000228811.6, ENST00000228811.7, F5H0D7, LPRP, NM_007244, PROL4, PROL4_HUMAN, Q16378, Q8NFB3, uc317doq.1, uc317doq.2
UCSC ID: ENST00000228811.8_10
RefSeq Accession: NM_007244.3
Protein: Q16378 (aka PROL4_HUMAN or PRL4_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.