Human Gene PRR15 (ENST00000319694.3_4) from GENCODE V47lift37
  Description: proline rich 15, transcript variant 1 (from RefSeq NM_175887.3)
Gencode Transcript: ENST00000319694.3_4
Gencode Gene: ENSG00000176532.4_9
Transcript (Including UTRs)
   Position: hg19 chr7:29,603,451-29,606,909 Size: 3,459 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr7:29,605,946-29,606,335 Size: 390 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:29,603,451-29,606,909)mRNA (may differ from genome)Protein (129 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PRR15_HUMAN
DESCRIPTION: RecName: Full=Proline-rich protein 15;
FUNCTION: May have a role in proliferation and/or differentiation (By similarity).
SIMILARITY: Belongs to the PRR15 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 45.72 RPKM in Colon - Transverse
Total median expression: 116.93 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -298.50688-0.434 Picture PostScript Text
3' UTR -141.20574-0.246 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15321 - ATPase family AAA domain containing 4

ModBase Predicted Comparative 3D Structure on Q8IV56
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0007275 multicellular organism development


-  Descriptions from all associated GenBank mRNAs
  BC029131 - Homo sapiens proline rich 15, mRNA (cDNA clone MGC:35424 IMAGE:5189352), complete cds.
JD245448 - Sequence 226472 from Patent EP1572962.
BC018144 - Homo sapiens proline rich 15, mRNA (cDNA clone IMAGE:3845782).
JD102432 - Sequence 83456 from Patent EP1572962.
JD127610 - Sequence 108634 from Patent EP1572962.
JD422556 - Sequence 403580 from Patent EP1572962.
JD144903 - Sequence 125927 from Patent EP1572962.
JD462243 - Sequence 443267 from Patent EP1572962.
JD116682 - Sequence 97706 from Patent EP1572962.
FJ857942 - Homo sapiens proline rich 15 (PRR15) mRNA, complete cds.
CU688604 - Synthetic construct Homo sapiens gateway clone IMAGE:100020598 5' read PRR15 mRNA.
HQ448380 - Synthetic construct Homo sapiens clone IMAGE:100071805; CCSB008476_04 proline rich 15 (PRR15) gene, encodes complete protein.
KJ895875 - Synthetic construct Homo sapiens clone ccsbBroadEn_05269 PRR15 gene, encodes complete protein.
JD313685 - Sequence 294709 from Patent EP1572962.
JD060062 - Sequence 41086 from Patent EP1572962.
JD320854 - Sequence 301878 from Patent EP1572962.
JD036878 - Sequence 17902 from Patent EP1572962.
JD391621 - Sequence 372645 from Patent EP1572962.
JD553848 - Sequence 534872 from Patent EP1572962.
JD159263 - Sequence 140287 from Patent EP1572962.
JD351124 - Sequence 332148 from Patent EP1572962.
JD429017 - Sequence 410041 from Patent EP1572962.
JD504224 - Sequence 485248 from Patent EP1572962.
JD203878 - Sequence 184902 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000319694.1, ENST00000319694.2, NM_175887, PRR15_HUMAN, Q8IV56, uc317qsl.1, uc317qsl.2
UCSC ID: ENST00000319694.3_4
RefSeq Accession: NM_175887.3
Protein: Q8IV56 (aka PRR15_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.