Human Gene PRR13 (ENST00000429243.7_8) from GENCODE V47lift37
  Description: proline rich 13, transcript variant 2 (from RefSeq NM_018457.4)
Gencode Transcript: ENST00000429243.7_8
Gencode Gene: ENSG00000205352.11_18
Transcript (Including UTRs)
   Position: hg19 chr12:53,835,518-53,840,422 Size: 4,905 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr12:53,836,499-53,839,843 Size: 3,345 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:53,835,518-53,840,422)mRNA (may differ from genome)Protein (148 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PRR13_HUMAN
DESCRIPTION: RecName: Full=Proline-rich protein 13; AltName: Full=Taxane-resistance protein;
FUNCTION: Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane- induced apoptosis.
SUBCELLULAR LOCATION: Nucleus.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 296.71 RPKM in Whole Blood
Total median expression: 4576.03 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.3079-0.219 Picture PostScript Text
3' UTR -164.40579-0.284 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q9NZ81
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  BC001464 - Homo sapiens proline rich 13, mRNA (cDNA clone IMAGE:3138621).
AF217517 - Homo sapiens uncharacterized bone marrow protein BM041 mRNA, complete cds.
AK296930 - Homo sapiens cDNA FLJ58476 complete cds, highly similar to Poly(rC)-binding protein 2.
BC014257 - Homo sapiens proline rich 13, mRNA (cDNA clone MGC:20629 IMAGE:4765821), complete cds.
BC016064 - Homo sapiens proline rich 13, mRNA (cDNA clone MGC:23563 IMAGE:4852862), complete cds.
BC066943 - Homo sapiens proline rich 13, mRNA (cDNA clone MGC:87320 IMAGE:4817871), complete cds.
AK074398 - Homo sapiens cDNA FLJ23818 fis, clone HSI07960.
BX640962 - Homo sapiens mRNA; cDNA DKFZp686D13148 (from clone DKFZp686D13148).
JD186681 - Sequence 167705 from Patent EP1572962.
JD186682 - Sequence 167706 from Patent EP1572962.
BC062322 - Homo sapiens proline rich 13, mRNA (cDNA clone IMAGE:5258490), with apparent retained intron.
BC021019 - Homo sapiens cDNA clone IMAGE:3623157.
BC071979 - Homo sapiens proline rich 13, mRNA (cDNA clone IMAGE:6651172).
CU688214 - Synthetic construct Homo sapiens gateway clone IMAGE:100021019 5' read PRR13 mRNA.
AB527901 - Synthetic construct DNA, clone: pF1KB0911, Homo sapiens PRR13 gene for proline rich protein 13, without stop codon, in Flexi system.
KJ906193 - Synthetic construct Homo sapiens clone ccsbBroadEn_15863 PRR13 gene, encodes complete protein.
HQ448476 - Synthetic construct Homo sapiens clone IMAGE:100071907; CCSB011017_01 proline rich 13 (PRR13) gene, encodes complete protein.
JF432575 - Synthetic construct Homo sapiens clone IMAGE:100073810 proline rich 13 (PRR13) gene, encodes complete protein.
CR533459 - Homo sapiens full open reading frame cDNA clone RZPDo834D0217D for gene DKFZP564J157, DKFZp564J157 protein; complete cds, incl. stopcodon.
KJ904768 - Synthetic construct Homo sapiens clone ccsbBroadEn_14162 PRR13-like gene, encodes complete protein.
DL491974 - Novel nucleic acids.
DL490530 - Novel nucleic acids.
BC004512 - Homo sapiens proline rich 13, mRNA (cDNA clone IMAGE:3927336).
JD174462 - Sequence 155486 from Patent EP1572962.
JD439890 - Sequence 420914 from Patent EP1572962.
JD394337 - Sequence 375361 from Patent EP1572962.
JD271630 - Sequence 252654 from Patent EP1572962.
JD411637 - Sequence 392661 from Patent EP1572962.
JD293042 - Sequence 274066 from Patent EP1572962.
JD331976 - Sequence 313000 from Patent EP1572962.
JD529857 - Sequence 510881 from Patent EP1572962.
JD146950 - Sequence 127974 from Patent EP1572962.
JD567005 - Sequence 548029 from Patent EP1572962.
JD539191 - Sequence 520215 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BM-041, ENST00000429243.1, ENST00000429243.2, ENST00000429243.3, ENST00000429243.4, ENST00000429243.5, ENST00000429243.6, NM_018457, PRR13_HUMAN, Q0V8U0, Q6FIG7, Q6MZP8, Q6NXQ6, Q6PKF9, Q9NZ81, TXR1, uc319yee.1, uc319yee.2
UCSC ID: ENST00000429243.7_8
RefSeq Accession: NM_018457.4
Protein: Q9NZ81 (aka PRR13_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.