ID:PRP18_HUMAN DESCRIPTION: RecName: Full=Pre-mRNA-splicing factor 18; AltName: Full=PRP18 homolog; Short=hPRP18; FUNCTION: Participates in the second step of pre-mRNA splicing. SUBUNIT: Heterodimer with PPIH. Interacts with PRPF4 and with the spliceosome. Part of a complex containing U4/U6 snRNPs. SUBCELLULAR LOCATION: Nucleus speckle (By similarity). Note=Colocalizes with spliceosomal snRNPs (By similarity). SIMILARITY: Belongs to the PRP18 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99633
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000386 second spliceosomal transesterification activity
Biological Process: GO:0000350 generation of catalytic spliceosome for second transesterification step GO:0006397 mRNA processing GO:0008380 RNA splicing GO:0071048 nuclear retention of unspliced pre-mRNA at the site of transcription
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
