ID:KPCD3_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein kinase D3; EC=2.7.11.13; AltName: Full=Protein kinase C nu type; AltName: Full=Protein kinase EPK2; AltName: Full=nPKC-nu; FUNCTION: Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium (By similarity). ENZYME REGULATION: Activated by DAG and phorbol esters. Phorbol- ester/DAG-type domains 1 and 2 bind both DAG and phorbol ester with high affinity and mediate translocation to the cell membrane. Autophosphorylation of Ser-735 and phosphorylation of Ser-731 by PKC relieves auto-inhibition by the PH domain. INTERACTION: P63027:VAMP2; NbExp=7; IntAct=EBI-1255366, EBI-520113; SUBCELLULAR LOCATION: Cytoplasm. Membrane. Note=Translocation to the cell membrane is required for kinase activation. TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 2 phorbol-ester/DAG-type zinc fingers. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O94806
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006468 protein phosphorylation GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway GO:0016310 phosphorylation GO:0030148 sphingolipid biosynthetic process GO:0035556 intracellular signal transduction GO:0089700 protein kinase D signaling
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
