Human Gene PRKCSH (ENST00000677123.1_3) from GENCODE V47lift37

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Description: protein kinase C substrate 80K-H, transcript variant 5 (from RefSeq NM_001289104.2)
Gencode Transcript: ENST00000677123.1_3
Gencode Gene: ENSG00000130175.10_20
Transcript (Including UTRs)
Position: hg19 chr19:11,546,456-11,561,783 Size: 15,328 Total Exon Count: 18 Strand: +
Coding Region
Position: hg19 chr19:11,546,939-11,560,227 Size: 13,289 Coding Exon Count: 16

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Pathways	Other Names
Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:11,546,456-11,561,783)			mRNA (may differ from genome)		Protein (535 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: PRKCSH Diseases sorted by gene-association score: polycystic liver disease 1* (928), polycystic liver disease* (522), liver disease (21), polycystic kidney disease 4, with or without hepatic disease (12), familial hemiplegic migraine (8), autosomal dominant polycystic kidney disease (6), hemiplegic migraine (6), polycystic kidney disease 2 (5), autosomal genetic disease (1) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D004054 Diethylstilbestrol D014635 Valproic Acid C495626 14-deoxy-11,12-didehydroandrographolide C011269 2,5-hexanedione C547126 AZM551248 D000535 Aluminum D001194 Asbestos D002994 Clofibrate D003993 Dibutyl Phthalate more ... click here to view the complete list

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-49.20	149	-0.330	Picture	PostScript	Text
3' UTR	-132.80	339	-0.392	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Descriptions from all associated GenBank mRNAs


	AK296187 - Homo sapiens cDNA FLJ59211 complete cds, highly similar to Glucosidase 2 subunit beta precursor. AK130663 - Homo sapiens cDNA FLJ27153 fis, clone SYN00678, highly similar to PROTEIN KINASE C SUBSTRATE, 80 KDA PROTEIN, HEAVY CHAIN. AK225279 - Homo sapiens mRNA for Glucosidase II beta subunit precursor variant, clone: HEP00314. J03075 - Human 80K-H protein (kinase C substrate) mRNA, complete cds. Z36798 - H.sapiens (xs147) mRNA, 400bp. AK225390 - Homo sapiens mRNA for Glucosidase II beta subunit precursor variant, clone: HRC03018. AK290433 - Homo sapiens cDNA FLJ78273 complete cds, highly similar to Homo sapiens protein kinase C substrate 80K-H (PRKCSH), transcript variant 2, mRNA. JD476567 - Sequence 457591 from Patent EP1572962. JD531609 - Sequence 512633 from Patent EP1572962. AB385574 - Synthetic construct DNA, clone: pF1KB9431, Homo sapiens PRKCSH gene for glucosidase 2 subunit beta precursor, complete cds, without stop codon, in Flexi system. AF144075 - Homo sapiens glucosidase II beta subunit mRNA, complete cds. BC013586 - Homo sapiens protein kinase C substrate 80K-H, mRNA (cDNA clone IMAGE:3892103), partial cds. BC128412 - Homo sapiens protein kinase C substrate 80K-H, mRNA (cDNA clone IMAGE:40117304), partial cds. CU680634 - Synthetic construct Homo sapiens gateway clone IMAGE:100019230 5' read PRKCSH mRNA. KU178278 - Homo sapiens protein kinase C substrate 80K-H isoform 1 (PRKCSH) mRNA, partial cds. KU178279 - Homo sapiens protein kinase C substrate 80K-H isoform 2 (PRKCSH) mRNA, partial cds, alternatively spliced. KU178280 - Homo sapiens protein kinase C substrate 80K-H isoform 4 (PRKCSH) mRNA, partial cds, alternatively spliced. KJ901662 - Synthetic construct Homo sapiens clone ccsbBroadEn_11056 PRKCSH gene, encodes complete protein. KR709720 - Synthetic construct Homo sapiens clone CCSBHm_00005347 PRKCSH (PRKCSH) mRNA, encodes complete protein. KR709721 - Synthetic construct Homo sapiens clone CCSBHm_00005348 PRKCSH (PRKCSH) mRNA, encodes complete protein. KR709722 - Synthetic construct Homo sapiens clone CCSBHm_00005349 PRKCSH (PRKCSH) mRNA, encodes complete protein. BT009858 - Homo sapiens protein kinase C substrate 80K-H mRNA, complete cds. DQ589514 - Homo sapiens piRNA piR-56626, complete sequence. BC015154 - Homo sapiens, clone IMAGE:3883364, mRNA, partial cds. JD377329 - Sequence 358353 from Patent EP1572962. JD143124 - Sequence 124148 from Patent EP1572962. JD115945 - Sequence 96969 from Patent EP1572962. JD173263 - Sequence 154287 from Patent EP1572962. JD566316 - Sequence 547340 from Patent EP1572962. JD124535 - Sequence 105559 from Patent EP1572962. JD347170 - Sequence 328194 from Patent EP1572962. JD243474 - Sequence 224498 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCyc Knowledge Library PWY-7919 - protein N-glycosylation processing phase (mammalian)

Other Names for This Gene


	Alternate Gene Symbols: K7ELL7, K7ELL7_HUMAN, NM_001289104, PRKCSH , uc330cdm.1, uc330cdm.2 UCSC ID: ENST00000677123.1_3 RefSeq Accession: NM_001289104.2

Gene Model Information


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Methods, Credits, and Use Restrictions


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