Human Gene PRDX6 (ENST00000340385.6_4) from GENCODE V47lift37
  Description: peroxiredoxin 6 (from RefSeq NM_004905.3)
Gencode Transcript: ENST00000340385.6_4
Gencode Gene: ENSG00000117592.9_7
Transcript (Including UTRs)
   Position: hg19 chr1:173,446,474-173,457,954 Size: 11,481 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr1:173,446,537-173,457,002 Size: 10,466 Coding Exon Count: 5 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:173,446,474-173,457,954)mRNA (may differ from genome)Protein (224 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PRDX6
Diseases sorted by gene-association score: gnathomiasis (2), fuchs' endothelial dystrophy (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 203.93 RPKM in Muscle - Skeletal
Total median expression: 4721.26 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -13.8063-0.219 Picture PostScript Text
3' UTR -230.00952-0.242 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Descriptions from all associated GenBank mRNAs
  AK300680 - Homo sapiens cDNA FLJ51310 complete cds, moderately similar to Peroxiredoxin-6 (EC 1.11.1.15).
BC035857 - Homo sapiens peroxiredoxin 6, mRNA (cDNA clone MGC:46173 IMAGE:5767682), complete cds.
EU794652 - Homo sapiens epididymis secretory sperm binding protein Li 128m (HEL-S-128m) mRNA, complete cds.
LP951971 - Sequence 2 from Patent EP3203240.
LZ177363 - JP 2017138214-A/1: Determination method of acute myocardial infarction.
AK289352 - Homo sapiens cDNA FLJ76595 complete cds, highly similar to Homo sapiens peroxiredoxin 6 (PRDX6), mRNA.
BC025421 - Homo sapiens cDNA clone IMAGE:4652118, containing frame-shift errors.
D14662 - Homo sapiens KIAA0106 mRNA, complete cds.
AB383749 - Synthetic construct DNA, clone: pF1KSDA0106, Homo sapiens PRDX6 gene for peroxiredoxin-6, complete cds, without stop codon, in Flexi system.
CU690218 - Synthetic construct Homo sapiens gateway clone IMAGE:100023296 5' read PRDX6 mRNA.
HQ448177 - Synthetic construct Homo sapiens clone IMAGE:100071571; CCSB010200_03 peroxiredoxin 6 (PRDX6) gene, encodes complete protein.
KJ892810 - Synthetic construct Homo sapiens clone ccsbBroadEn_02204 PRDX6 gene, encodes complete protein.
BC053550 - Homo sapiens peroxiredoxin 6, mRNA (cDNA clone MGC:61484 IMAGE:6013037), complete cds.
AJ844621 - Homo sapiens partial mRNA for peroxiredoxin 6 (PRDX6 gene).
EF036493 - Homo sapiens peroxiredoxin 6 mRNA, partial cds.
JD026862 - Sequence 7886 from Patent EP1572962.
AK095940 - Homo sapiens cDNA FLJ38621 fis, clone HEART2008111.
JD256054 - Sequence 237078 from Patent EP1572962.
JD558632 - Sequence 539656 from Patent EP1572962.
JD531817 - Sequence 512841 from Patent EP1572962.
JD502022 - Sequence 483046 from Patent EP1572962.
JD419265 - Sequence 400289 from Patent EP1572962.
JD151241 - Sequence 132265 from Patent EP1572962.
JD499619 - Sequence 480643 from Patent EP1572962.
JD564771 - Sequence 545795 from Patent EP1572962.
AJ844622 - Homo sapiens partial mRNA for peroxiredoxin 6 (PRDX6 gene), 3'UTR.
JD521114 - Sequence 502138 from Patent EP1572962.
JD205360 - Sequence 186384 from Patent EP1572962.
JD078222 - Sequence 59246 from Patent EP1572962.
JD020258 - Sequence 1282 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A024R938, ENST00000340385.1, ENST00000340385.2, ENST00000340385.3, ENST00000340385.4, ENST00000340385.5, HEL-S-128m , NM_004905, uc317vqu.1, uc317vqu.2, V9HWC7, V9HWC7_HUMAN
UCSC ID: ENST00000340385.6_4
RefSeq Accession: NM_004905.3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.