Human Gene PPP4R4 (ENST00000304338.8_4) from GENCODE V47lift37

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Description: protein phosphatase 4 regulatory subunit 4, transcript variant 7 (from RefSeq NR_145441.2)
Gencode Transcript: ENST00000304338.8_4
Gencode Gene: ENSG00000119698.12_8
Transcript (Including UTRs)
Position: hg19 chr14:94,640,659-94,746,071 Size: 105,413 Total Exon Count: 25 Strand: +
Coding Region
Position: hg19 chr14:94,640,803-94,744,980 Size: 104,178 Coding Exon Count: 25

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr14:94,640,659-94,746,071)			mRNA (may differ from genome)		Protein (873 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: PP4R4_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase 4 regulatory subunit 4; FUNCTION: Putative regulatory subunit of serine/threonine-protein phosphatase 4. SUBUNIT: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R4. INTERACTION: P60510:PPP4C; NbExp=6; IntAct=EBI-1774189, EBI-1046072; SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Contains 3 HEAT repeats. SEQUENCE CAUTION: Sequence=BAB13448.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D000535 Aluminum D001564 Benzo(a)pyrene D004390 Chlorpyrifos D016572 Cyclosporine D004958 Estradiol D011794 Quercetin D014212 Tretinoin C045651 epigallocatechin gallate C006253 pirinixic acid C027373 potassium chromate(VI)

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 7.76 RPKM in Brain - Anterior cingulate cortex (BA24) Total median expression: 75.07 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-83.50	144	-0.580	Picture	PostScript	Text
3' UTR	-251.10	1091	-0.230	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR016024 - ARM-type_fold
IPR021133 - HEAT_type_2

SCOP Domains:
48371 - ARM repeat
48431 - Lipovitellin-phosvitin complex, superhelical domain

ModBase Predicted Comparative 3D Structure on Q6NUP7


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details			Gene Details
Gene Sorter	Gene Sorter			Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0019888 protein phosphatase regulator activity Biological Process: GO:0032515 negative regulation of phosphoprotein phosphatase activity GO:0080163 regulation of protein serine/threonine phosphatase activity Cellular Component: GO:0005737 cytoplasm GO:0005829 cytosol GO:0008287 protein serine/threonine phosphatase complex

Descriptions from all associated GenBank mRNAs


	BC002650 - Homo sapiens protein phosphatase 4, regulatory subunit 4, mRNA (cDNA clone IMAGE:3609245), complete cds. BC068491 - Homo sapiens protein phosphatase 4, regulatory subunit 4, mRNA (cDNA clone MGC:87177 IMAGE:5297335), complete cds. AB046842 - Homo sapiens KIAA1622 mRNA for KIAA1622 protein. AB385489 - Synthetic construct DNA, clone: pF1KA1622, Homo sapiens KIAA1622 gene for HEAT-like repeat-containing protein isoform 1, complete cds, without stop codon, in Flexi system. CU686649 - Synthetic construct Homo sapiens gateway clone IMAGE:100022969 5' read KIAA1622 mRNA. KJ894452 - Synthetic construct Homo sapiens clone ccsbBroadEn_03846 PPP4R4 gene, encodes complete protein. AK303722 - Homo sapiens cDNA FLJ56834 complete cds. JD429031 - Sequence 410055 from Patent EP1572962. JD310626 - Sequence 291650 from Patent EP1572962. JD196718 - Sequence 177742 from Patent EP1572962. JD068937 - Sequence 49961 from Patent EP1572962. JD246034 - Sequence 227058 from Patent EP1572962. JD327113 - Sequence 308137 from Patent EP1572962. JD215474 - Sequence 196498 from Patent EP1572962. JD080183 - Sequence 61207 from Patent EP1572962. JD553778 - Sequence 534802 from Patent EP1572962. JD047241 - Sequence 28265 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000304338.1, ENST00000304338.2, ENST00000304338.3, ENST00000304338.4, ENST00000304338.5, ENST00000304338.6, ENST00000304338.7, KIAA1622, NR_145441, PP4R4, PP4R4_HUMAN, Q6NUP7, Q9BUF8, Q9HCF0, uc317nkf.1, uc317nkf.2 UCSC ID: ENST00000304338.8_4 RefSeq Accession: NM_058237.2 Protein: Q6NUP7 (aka PP4R4_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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