Human Gene PPP2R3B (ENST00000390665.9_7) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: P2R3B_HUMAN
DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta; AltName: Full=PP2A subunit B isoform PR48; AltName: Full=Protein phosphatase 2A 48 kDa regulatory subunit;
FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with N-terminal region of CDC6.
SUBCELLULAR LOCATION: Nucleus.
MISCELLANEOUS: The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
SIMILARITY: Contains 1 EF-hand domain.
SEQUENCE CAUTION: Sequence=AAD38515.1; Type=Erroneous initiation;
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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The following chemicals interact with this gene
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 Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR018247 - EF_Hand_1_Ca_BS
IPR018249 - EF_HAND_2
Pfam Domains:
PF13202 - EF hand
PF13499 - EF-hand domain pair
PF17958 - EF-hand domain
SCOP Domains:
47473 - EF-hand
ModBase Predicted Comparative 3D Structure on Q9Y5P8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
| Mouse | Rat | Zebrafish | D. melanogaster | C. elegans | S. cerevisiae |
| No ortholog | No ortholog | No ortholog | No ortholog | No ortholog | No ortholog |
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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AL157501 - Homo sapiens mRNA; cDNA DKFZp434G155 (from clone DKFZp434G155); partial cds.
AF155098 - Homo sapiens NY-REN-8 antigen mRNA, partial cds.
AB209137 - Homo sapiens mRNA for NY-REN-8 antigen variant protein.
BC009032 - Homo sapiens protein phosphatase 2 (formerly 2A), regulatory subunit B'', beta, mRNA (cDNA clone IMAGE:4214447), complete cds.
BC011180 - Homo sapiens protein phosphatase 2 (formerly 2A), regulatory subunit B'', beta, mRNA (cDNA clone IMAGE:4150858), partial cds.
BC063429 - Homo sapiens protein phosphatase 2 (formerly 2A), regulatory subunit B'', beta, mRNA (cDNA clone MGC:75042 IMAGE:5239974), complete cds.
AF135016 - Homo sapiens protein phosphatase 2A 48 kDa regulatory subunit mRNA, complete cds.
JD415787 - Sequence 396811 from Patent EP1572962.
KJ902475 - Synthetic construct Homo sapiens clone ccsbBroadEn_11869 PPP2R3B gene, encodes complete protein.
HQ447089 - Synthetic construct Homo sapiens clone IMAGE:100070372; CCSB008591_02 protein phosphatase 2 (formerly 2A), regulatory subunit B'', beta (PPP2R3B) gene, encodes complete protein.
KJ902474 - Synthetic construct Homo sapiens clone ccsbBroadEn_11868 PPP2R3B gene, encodes complete protein.
AB590904 - Synthetic construct DNA, clone: pFN21AE1996, Homo sapiens PPP2R3B gene for protein phosphatase 2 (formerly 2A), regulatory subunit B'', beta, without stop codon, in Flexi system.
CU679892 - Synthetic construct Homo sapiens gateway clone IMAGE:100016813 5' read PPP2R3B mRNA.
DQ600381 - Homo sapiens piRNA piR-38447, complete sequence.
AK293506 - Homo sapiens cDNA FLJ60425 complete cds, highly similar to Serine/threonine-protein phosphatase 2A 48 kDa regulatory subunit B.
JD115642 - Sequence 96666 from Patent EP1572962.
JD395967 - Sequence 376991 from Patent EP1572962.
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Biochemical and Signaling Pathways
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Other Names for This Gene
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Alternate Gene Symbols: ENST00000390665.1, ENST00000390665.2, ENST00000390665.3, ENST00000390665.4, ENST00000390665.5, ENST00000390665.6, ENST00000390665.7, ENST00000390665.8, NM_013239, P2R3B_HUMAN, PPP2R3L, Q6P4G9, Q7RTT1, Q96H01, Q9Y5P8, uc318txq.1, uc318txq.2
UCSC ID: ENST00000390665.9_7
RefSeq Accession: NM_013239.5
Protein: Q9Y5P8
(aka P2R3B_HUMAN)
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
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US Server
