Human Gene PPP1R9A (ENST00000433360.6_5) from GENCODE V47lift37
  Description: protein phosphatase 1 regulatory subunit 9A, transcript variant 1 (from RefSeq NM_001166160.2)
Gencode Transcript: ENST00000433360.6_5
Gencode Gene: ENSG00000158528.12_13
Transcript (Including UTRs)
   Position: hg19 chr7:94,536,906-94,925,712 Size: 388,807 Total Exon Count: 20 Strand: +
Coding Region
   Position: hg19 chr7:94,539,426-94,919,615 Size: 380,190 Coding Exon Count: 19 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:94,536,906-94,925,712)mRNA (may differ from genome)Protein (1374 aa)
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WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NEB1_HUMAN
DESCRIPTION: RecName: Full=Neurabin-1; AltName: Full=Neurabin-I; AltName: Full=Neural tissue-specific F-actin-binding protein I; AltName: Full=Protein phosphatase 1 regulatory subunit 9A;
FUNCTION: Binds to actin filaments (F-actin) and shows cross- linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1- alpha activity (By similarity).
SUBUNIT: Possibly exists as a homodimer, homotrimer or a homotetramer. Interacts with F-actin, protein phosphatase 1 (PP1), neurabin-2 and p70-S6K (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Cell junction, synapse, synaptosome (By similarity).
DOMAIN: Interacts with p70-S6K via its PDZ domain (By similarity).
DOMAIN: The PP1 binding region is natively unstructured, upon PP1 binding, it acquires structure, blocks a substrate-binding site, and restricts PP1 phosphatase specificity to a subset of substrates (By similarity).
SIMILARITY: Contains 1 PDZ (DHR) domain.
SIMILARITY: Contains 1 SAM (sterile alpha motif) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PPP1R9A
Diseases sorted by gene-association score: hepatosplenic t-cell lymphoma (10)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.00 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 140.57 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -80.90325-0.249 Picture PostScript Text
3' UTR -1589.606097-0.261 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001478 - PDZ
IPR001660 - SAM
IPR013761 - SAM/pointed
IPR011510 - SAM_2

Pfam Domains:
PF00536 - SAM domain (Sterile alpha motif)
PF00595 - PDZ domain
PF07647 - SAM domain (Sterile alpha motif)
PF17817 - PDZ domain

SCOP Domains:
47769 - SAM/Pointed domain
50156 - PDZ domain-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1WF8 - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q9ULJ8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008157 protein phosphatase 1 binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0042803 protein homodimerization activity
GO:0044325 ion channel binding
GO:0044877 macromolecular complex binding
GO:0051015 actin filament binding
GO:0051020 GTPase binding

Biological Process:
GO:0007015 actin filament organization
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0007568 aging
GO:0010976 positive regulation of neuron projection development
GO:0019722 calcium-mediated signaling
GO:0030154 cell differentiation
GO:0030833 regulation of actin filament polymerization
GO:0031175 neuron projection development
GO:0045860 positive regulation of protein kinase activity
GO:0048666 neuron development
GO:0051489 regulation of filopodium assembly
GO:0051497 negative regulation of stress fiber assembly
GO:0051823 regulation of synapse structural plasticity
GO:0051963 regulation of synapse assembly
GO:0060079 excitatory postsynaptic potential
GO:0060999 positive regulation of dendritic spine development
GO:0061001 regulation of dendritic spine morphogenesis
GO:0097237 cellular response to toxic substance
GO:1900272 negative regulation of long-term synaptic potentiation
GO:1900454 positive regulation of long term synaptic depression
GO:1904049 negative regulation of spontaneous neurotransmitter secretion

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0014069 postsynaptic density
GO:0015629 actin cytoskeleton
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030175 filopodium
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030864 cortical actin cytoskeleton
GO:0031594 neuromuscular junction
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0044326 dendritic spine neck
GO:0045202 synapse
GO:1990761 growth cone lamellipodium


-  Descriptions from all associated GenBank mRNAs
  AK096514 - Homo sapiens cDNA FLJ39195 fis, clone OCBBF2004984, weakly similar to Homo sapiens mRNA for neurabin II protein.
BC150636 - Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 9A, mRNA (cDNA clone MGC:183546 IMAGE:9057006), complete cds.
BC130449 - Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 9A, mRNA (cDNA clone MGC:163321 IMAGE:40146480), complete cds.
BC144108 - Homo sapiens cDNA clone IMAGE:9052628.
BC144109 - Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 9A, mRNA (cDNA clone MGC:177646 IMAGE:9052629), complete cds.
AB033048 - Homo sapiens mRNA for KIAA1222 protein, partial cds.
DQ573645 - Homo sapiens piRNA piR-41757, complete sequence.
AK225204 - Homo sapiens mRNA for protein phosphatase 1, regulatory (inhibitor) subunit 9A variant, clone: COL01755.
AK000075 - Homo sapiens cDNA FLJ20068 fis, clone COL01755.
JD079701 - Sequence 60725 from Patent EP1572962.
JD116284 - Sequence 97308 from Patent EP1572962.
JD261365 - Sequence 242389 from Patent EP1572962.
JD241864 - Sequence 222888 from Patent EP1572962.
JD260610 - Sequence 241634 from Patent EP1572962.
JD448052 - Sequence 429076 from Patent EP1572962.
JD156612 - Sequence 137636 from Patent EP1572962.
JD146068 - Sequence 127092 from Patent EP1572962.
JD315046 - Sequence 296070 from Patent EP1572962.
JD438416 - Sequence 419440 from Patent EP1572962.
JD389968 - Sequence 370992 from Patent EP1572962.
JD386952 - Sequence 367976 from Patent EP1572962.
BC037849 - Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 9A, mRNA (cDNA clone IMAGE:4815736).
JD022252 - Sequence 3276 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A1L494, B2RWQ1, E9PCA0, E9PCK6, E9PDX1, ENST00000433360.1, ENST00000433360.2, ENST00000433360.3, ENST00000433360.4, ENST00000433360.5, F8W7J9, KIAA1222, NEB1_HUMAN, NM_001166160, O76059, Q9NXT2, Q9ULJ8, uc320bya.1, uc320bya.2
UCSC ID: ENST00000433360.6_5
RefSeq Accession: NM_001166160.2
Protein: Q9ULJ8 (aka NEB1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.