Human Gene PPP1R3F (ENST00000055335.11_7) from GENCODE V47lift37
  Description: protein phosphatase 1 regulatory subunit 3F, transcript variant 1 (from RefSeq NM_033215.5)
Gencode Transcript: ENST00000055335.11_7
Gencode Gene: ENSG00000049769.14_10
Transcript (Including UTRs)
   Position: hg19 chrX:49,126,256-49,144,552 Size: 18,297 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chrX:49,126,333-49,143,552 Size: 17,220 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:49,126,256-49,144,552)mRNA (may differ from genome)Protein (799 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PPR3F_HUMAN
DESCRIPTION: RecName: Full=Protein phosphatase 1 regulatory subunit 3F; Short=R3F;
FUNCTION: Glycogen-targeting subunit for protein phosphatase 1 (PP1).
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (By similarity).
TISSUE SPECIFICITY: Expressed in brain, skeletal muscle and heart.
SIMILARITY: Contains 1 CBM21 (carbohydrate binding type-21) domain.
SEQUENCE CAUTION: Sequence=BAG51824.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.92 RPKM in Brain - Cortex
Total median expression: 284.26 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -28.4077-0.369 Picture PostScript Text
3' UTR -326.001000-0.326 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005036 - CBM_21

Pfam Domains:
PF03370 - Carbohydrate/starch-binding module (family 21)
PF16760 - Starch/carbohydrate-binding module (family 53)

ModBase Predicted Comparative 3D Structure on Q6ZSY5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0019903 protein phosphatase binding
GO:2001069 glycogen binding

Biological Process:
GO:0005979 regulation of glycogen biosynthetic process
GO:2000465 regulation of glycogen (starch) synthase activity

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF211393 - JP 2014500723-A/18896: Polycomb-Associated Non-Coding RNAs.
LF211394 - JP 2014500723-A/18897: Polycomb-Associated Non-Coding RNAs.
AK303738 - Homo sapiens cDNA FLJ56283 complete cds, highly similar to Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 3F (PPP1R3F), mRNA.
BC131588 - Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 3F, mRNA (cDNA clone IMAGE:40113297), partial cds.
AK056909 - Homo sapiens cDNA FLJ32347 fis, clone PROST2006988, highly similar to Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 3F (PPP1R3F), mRNA.
AK056297 - Homo sapiens cDNA FLJ31735 fis, clone NT2RI2007048, highly similar to Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 3F (PPP1R3F), mRNA.
AK127066 - Homo sapiens cDNA FLJ45123 fis, clone BRAWH3036270, highly similar to Homo sapiens Hb2E.
BC110405 - Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 3F, mRNA (cDNA clone IMAGE:5729609), partial cds.
LF378986 - JP 2014500723-A/186489: Polycomb-Associated Non-Coding RNAs.
JD111728 - Sequence 92752 from Patent EP1572962.
LF378985 - JP 2014500723-A/186488: Polycomb-Associated Non-Coding RNAs.
JD043555 - Sequence 24579 from Patent EP1572962.
JD175201 - Sequence 156225 from Patent EP1572962.
JD164595 - Sequence 145619 from Patent EP1572962.
LF378984 - JP 2014500723-A/186487: Polycomb-Associated Non-Coding RNAs.
JD358404 - Sequence 339428 from Patent EP1572962.
JD152592 - Sequence 133616 from Patent EP1572962.
LF378983 - JP 2014500723-A/186486: Polycomb-Associated Non-Coding RNAs.
LF378982 - JP 2014500723-A/186485: Polycomb-Associated Non-Coding RNAs.
MA446970 - JP 2018138019-A/18896: Polycomb-Associated Non-Coding RNAs.
MA446971 - JP 2018138019-A/18897: Polycomb-Associated Non-Coding RNAs.
MA614563 - JP 2018138019-A/186489: Polycomb-Associated Non-Coding RNAs.
MA614562 - JP 2018138019-A/186488: Polycomb-Associated Non-Coding RNAs.
MA614561 - JP 2018138019-A/186487: Polycomb-Associated Non-Coding RNAs.
MA614560 - JP 2018138019-A/186486: Polycomb-Associated Non-Coding RNAs.
MA614559 - JP 2018138019-A/186485: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A2VDJ8, B3KPW2, E9PCM3, ENST00000055335.1, ENST00000055335.10, ENST00000055335.2, ENST00000055335.3, ENST00000055335.4, ENST00000055335.5, ENST00000055335.6, ENST00000055335.7, ENST00000055335.8, ENST00000055335.9, NM_033215, PPR3F_HUMAN, Q6ZSY5, uc317cad.1, uc317cad.2
UCSC ID: ENST00000055335.11_7
RefSeq Accession: NM_033215.5
Protein: Q6ZSY5 (aka PPR3F_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.