ID:PPM1E_HUMAN DESCRIPTION: RecName: Full=Protein phosphatase 1E; EC=3.1.3.16; AltName: Full=Ca(2+)/calmodulin-dependent protein kinase phosphatase N; Short=CaMKP-N; AltName: Full=CaMKP-nucleus; Short=CaMKN; AltName: Full=Partner of PIX 1; AltName: Full=Partner of PIX-alpha; Short=Partner of PIXA; FUNCTION: Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. COFACTOR: Binds 2 magnesium or manganese ions per subunit (By similarity). SUBUNIT: Heterotrimer. Interacts with PAX1 and ARHGEF6 (or ARHGEF7). SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full length, minor form, is found in the nucleus. POLYMORPHISM: The poly-Pro-Glu stretch is polymorphic. SIMILARITY: Belongs to the PP2C family. SIMILARITY: Contains 1 PP2C-like domain. SEQUENCE CAUTION: Sequence=BAA83024.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8WY54
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006469 negative regulation of protein kinase activity GO:0006470 protein dephosphorylation GO:0035690 cellular response to drug GO:0035970 peptidyl-threonine dephosphorylation GO:0051496 positive regulation of stress fiber assembly
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
