Human Gene PPIL3 (ENST00000392283.9_7) from GENCODE V47lift37
  Description: peptidylprolyl isomerase like 3, transcript variant PPIL3b (from RefSeq NM_130906.3)
Gencode Transcript: ENST00000392283.9_7
Gencode Gene: ENSG00000240344.10_9
Transcript (Including UTRs)
   Position: hg19 chr2:201,735,630-201,753,800 Size: 18,171 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr2:201,736,118-201,752,338 Size: 16,221 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:201,735,630-201,753,800)mRNA (may differ from genome)Protein (161 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PPIL3_HUMAN
DESCRIPTION: RecName: Full=Peptidyl-prolyl cis-trans isomerase-like 3; Short=PPIase; EC=5.2.1.8; AltName: Full=Cyclophilin J; Short=CyPJ; AltName: Full=Cyclophilin-like protein PPIL3; AltName: Full=Rotamase PPIL3;
FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.
CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0).
SUBUNIT: Identified in the spliceosome C complex.
INTERACTION: Q99152:VP3 (xeno); NbExp=3; IntAct=EBI-751051, EBI-1776808;
TISSUE SPECIFICITY: Ubiquitous. Detected at low levels.
SIMILARITY: Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.
SIMILARITY: Contains 1 PPIase cyclophilin-type domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.66 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 375.08 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -40.20192-0.209 Picture PostScript Text
3' UTR -77.70488-0.159 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002130 - Cyclophilin-like_PPIase_dom
IPR024936 - Cyclophilin-type_PPIase
IPR020892 - Cyclophilin-type_PPIase_CS

Pfam Domains:
PF00160 - Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

SCOP Domains:
50891 - Cyclophilin-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1XYH - X-ray MuPIT 2OJU - X-ray MuPIT 2OK3 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9H2H8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0016853 isomerase activity

Biological Process:
GO:0000398 mRNA splicing, via spliceosome
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006397 mRNA processing
GO:0006457 protein folding
GO:0008380 RNA splicing

Cellular Component:
GO:0005681 spliceosomal complex
GO:0071013 catalytic step 2 spliceosome


-  Descriptions from all associated GenBank mRNAs
  AK297804 - Homo sapiens cDNA FLJ60725 complete cds, highly similar to Peptidyl-prolyl cis-trans isomerase-like 3(EC 5.2.1.8).
AF271652 - Homo sapiens cyclophilin-like protein PPIL3b (PPIL3) mRNA, complete cds, alternatively spliced.
LF383608 - JP 2014500723-A/191111: Polycomb-Associated Non-Coding RNAs.
AY257468 - Homo sapiens peptidylprolyl isomerase-like protein 3 isoform PPIL3d (PPIL3) mRNA, complete cds; alternatively spliced.
AF414127 - Homo sapiens peptidylprolyl isomerase-like 3 isoform B (PPIL3) mRNA, complete cds.
AF146799 - Homo sapiens cyclophilin mRNA, complete cds.
AF251049 - Homo sapiens cyclophilin-like protein mRNA, complete cds.
BC007693 - Homo sapiens peptidylprolyl isomerase (cyclophilin)-like 3, mRNA (cDNA clone MGC:10732 IMAGE:3956681), complete cds.
BC031679 - Homo sapiens, clone IMAGE:5112065, mRNA.
JD067337 - Sequence 48361 from Patent EP1572962.
JD181121 - Sequence 162145 from Patent EP1572962.
JD351356 - Sequence 332380 from Patent EP1572962.
JD268917 - Sequence 249941 from Patent EP1572962.
AK027315 - Homo sapiens cDNA FLJ14409 fis, clone HEMBA1004408, moderately similar to PEPTIDYL-PROLYL CIS-TRANS ISOMERASE 10 (EC 5.2.1.8).
JF432727 - Synthetic construct Homo sapiens clone IMAGE:100073970 peptidylprolyl isomerase (cyclophilin)-like 3 (PPIL3) gene, encodes complete protein.
KJ898962 - Synthetic construct Homo sapiens clone ccsbBroadEn_08356 PPIL3 gene, encodes complete protein.
KU178646 - Homo sapiens peptidylprolyl isomerase -like 3 isoform 1 (PPIL3) mRNA, partial cds.
KU178647 - Homo sapiens peptidylprolyl isomerase -like 3 isoform 2 (PPIL3) mRNA, complete cds, alternatively spliced.
KU178648 - Homo sapiens peptidylprolyl isomerase -like 3 isoform 3 (PPIL3) mRNA, partial cds.
JD047180 - Sequence 28204 from Patent EP1572962.
JD292907 - Sequence 273931 from Patent EP1572962.
JD529017 - Sequence 510041 from Patent EP1572962.
JD380016 - Sequence 361040 from Patent EP1572962.
JD124930 - Sequence 105954 from Patent EP1572962.
MA619185 - JP 2018138019-A/191111: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9H2H8 (Reactome details) participates in the following event(s):

R-HSA-72127 Formation of the Spliceosomal B Complex
R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage
R-HSA-72139 Formation of the active Spliceosomal C (B*) complex
R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex
R-HSA-156661 Formation of Exon Junction Complex
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72172 mRNA Splicing
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-8953854 Metabolism of RNA

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000392283.1, ENST00000392283.2, ENST00000392283.3, ENST00000392283.4, ENST00000392283.5, ENST00000392283.6, ENST00000392283.7, ENST00000392283.8, NM_130906, PPIL3_HUMAN, Q86WF9, Q96IA9, Q9BXZ1, Q9H2H8, uc318uyy.1, uc318uyy.2
UCSC ID: ENST00000392283.9_7
RefSeq Accession: NM_130906.3
Protein: Q9H2H8 (aka PPIL3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.