Human Gene POTEI (ENST00000451531.7_7) from GENCODE V47lift37
  Description: POTE ankyrin domain family member I, transcript variant 1 (from RefSeq NM_001371926.1)
Gencode Transcript: ENST00000451531.7_7
Gencode Gene: ENSG00000196834.14_12
Transcript (Including UTRs)
   Position: hg19 chr2:131,217,028-131,266,901 Size: 49,874 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg19 chr2:131,220,389-131,266,808 Size: 46,420 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:131,217,028-131,266,901)mRNA (may differ from genome)Protein (1075 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: POTEI_HUMAN
DESCRIPTION: RecName: Full=POTE ankyrin domain family member I;
SIMILARITY: In the N-terminal section; belongs to the POTE family.
SIMILARITY: In the C-terminal section; belongs to the actin family.
SIMILARITY: Contains 5 ANK repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.68 RPKM in Testis
Total median expression: 2.25 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -27.4093-0.295 Picture PostScript Text
3' UTR -1123.403361-0.334 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004000 - Actin-like
IPR020902 - Actin/actin-like_CS
IPR004001 - Actin_CS
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom

Pfam Domains:
PF00022 - Actin
PF00023 - Ankyrin repeat
PF12796 - Ankyrin repeats (3 copies)
PF13637 - Ankyrin repeats (many copies)
PF13857 - Ankyrin repeats (many copies)
PF14915 - CCDC144C protein coiled-coil region

SCOP Domains:
140860 - Pseudo ankyrin repeat-like
53067 - Actin-like ATPase domain
48403 - Ankyrin repeat

ModBase Predicted Comparative 3D Structure on P0CG38
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0001895 retina homeostasis

Cellular Component:
GO:0005615 extracellular space
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  DQ587076 - Homo sapiens piRNA piR-54188, complete sequence.
DQ572062 - Homo sapiens piRNA piR-40174, complete sequence.
DQ589377 - Homo sapiens piRNA piR-56489, complete sequence.
JD234537 - Sequence 215561 from Patent EP1572962.
JD301785 - Sequence 282809 from Patent EP1572962.
JD172487 - Sequence 153511 from Patent EP1572962.
JD056756 - Sequence 37780 from Patent EP1572962.
DQ585384 - Homo sapiens piRNA piR-52496, complete sequence.
HM358987 - Homo sapiens clone HepG-13 actin-like mRNA, partial sequence.
DQ580140 - Homo sapiens piRNA piR-48252, complete sequence.
JD155329 - Sequence 136353 from Patent EP1572962.
JD315570 - Sequence 296594 from Patent EP1572962.
DQ590292 - Homo sapiens piRNA piR-57404, complete sequence.
JD504529 - Sequence 485553 from Patent EP1572962.
DQ585623 - Homo sapiens piRNA piR-52735, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000451531.1, ENST00000451531.2, ENST00000451531.3, ENST00000451531.4, ENST00000451531.5, ENST00000451531.6, NM_001371926, P0CG38, POTEI_HUMAN, uc320sxc.1, uc320sxc.2
UCSC ID: ENST00000451531.7_7
RefSeq Accession: NM_001277406.2
Protein: P0CG38 (aka POTEI_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.