ID:COLI_HUMAN DESCRIPTION: RecName: Full=Pro-opiomelanocortin; Short=POMC; AltName: Full=Corticotropin-lipotropin; Contains: RecName: Full=NPP; Contains: RecName: Full=Melanotropin gamma; AltName: Full=Gamma-MSH; Contains: RecName: Full=Potential peptide; Contains: RecName: Full=Corticotropin; AltName: Full=Adrenocorticotropic hormone; Short=ACTH; Contains: RecName: Full=Melanotropin alpha; AltName: Full=Alpha-MSH; Contains: RecName: Full=Corticotropin-like intermediary peptide; Short=CLIP; Contains: RecName: Full=Lipotropin beta; AltName: Full=Beta-LPH; Contains: RecName: Full=Lipotropin gamma; AltName: Full=Gamma-LPH; Contains: RecName: Full=Melanotropin beta; AltName: Full=Beta-MSH; Contains: RecName: Full=Beta-endorphin; Contains: RecName: Full=Met-enkephalin; Flags: Precursor; FUNCTION: ACTH stimulates the adrenal glands to release cortisol. FUNCTION: MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes. FUNCTION: Beta-endorphin and Met-enkephalin are endogenous opiates. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: ACTH and MSH are produced by the pituitary gland. PTM: Specific enzymatic cleavages at paired basic residues yield the different active peptides. PTM: O-glycosylated; reducing sugar is probably N- acetylgalactosamine. DISEASE: Defects in POMC may be associated with susceptibility to obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. DISEASE: Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD) [MIM:609734]. Affected individuals present early-onset obesity, adrenal insufficiency and red hair. SIMILARITY: Belongs to the POMC family. WEB RESOURCE: Name=Wikipedia; Note=Melanocyte-stimulating hormone entry; URL="http://en.wikipedia.org/wiki/Melanocyte-stimulating_hormone";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P01189
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006091 generation of precursor metabolites and energy GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007218 neuropeptide signaling pathway GO:0007267 cell-cell signaling GO:0008217 regulation of blood pressure GO:0010469 regulation of receptor activity GO:0019221 cytokine-mediated signaling pathway GO:0031640 killing of cells of other organism GO:0032098 regulation of appetite GO:0032720 negative regulation of tumor necrosis factor production GO:0033059 cellular pigmentation GO:0035821 modification of morphology or physiology of other organism GO:0042593 glucose homeostasis GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0070873 regulation of glycogen metabolic process GO:0070965 positive regulation of neutrophil mediated killing of fungus GO:2000852 regulation of corticosterone secretion
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
