Human Gene POLR2A (ENST00000674977.2_4) from GENCODE V47lift37

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Description: RNA polymerase II subunit A (from RefSeq NM_000937.5)
Gencode Transcript: ENST00000674977.2_4
Gencode Gene: ENSG00000181222.19_11
Transcript (Including UTRs)
Position: hg19 chr17:7,387,685-7,417,496 Size: 29,812 Total Exon Count: 30 Strand: +
Coding Region
Position: hg19 chr17:7,388,084-7,417,496 Size: 29,413 Coding Exon Count: 30

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Other Names	Model Information
Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr17:7,387,685-7,417,496)			mRNA (may differ from genome)		Protein (1967 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: POLR2A Diseases sorted by gene-association score: la crosse encephalitis (11), uv-sensitive syndrome (8), subcutaneous mycosis (7), herpes simplex (5), hiv-1 (4)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C553472 3-(4-methylpiperazin)-8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carbonitrile D001564 Benzo(a)pyrene C049325 1,2-dithiol-3-thione C016403 2,4-dinitrotoluene C120275 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone C075773 4-phenylbutyric acid D000082 Acetaminophen D016604 Aflatoxin B1 D001241 Aspirin D001280 Atrazine more ... click here to view the complete list

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-164.30	399	-0.412	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	Genome Browser
Gene Details	Gene Details		Gene Details	Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase	SGD
				Protein Sequence	Protein Sequence
				Alignment	Alignment

Descriptions from all associated GenBank mRNAs


	AK304882 - Homo sapiens cDNA FLJ61585 complete cds, highly similar to DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6). LF209143 - JP 2014500723-A/16646: Polycomb-Associated Non-Coding RNAs. AK293777 - Homo sapiens cDNA FLJ53860 complete cds, highly similar to DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6). X63564 - H.sapiens mRNA for RNA polymerase II largest subunit. JD360686 - Sequence 341710 from Patent EP1572962. JD037458 - Sequence 18482 from Patent EP1572962. LF326421 - JP 2014500723-A/133924: Polycomb-Associated Non-Coding RNAs. JD404262 - Sequence 385286 from Patent EP1572962. JD037143 - Sequence 18167 from Patent EP1572962. BC137231 - Homo sapiens polymerase (RNA) II (DNA directed) polypeptide A, 220kDa, mRNA (cDNA clone MGC:168851 IMAGE:9021228), complete cds. JD127182 - Sequence 108206 from Patent EP1572962. BC067295 - Homo sapiens polymerase (RNA) II (DNA directed) polypeptide A, 220kDa, mRNA (cDNA clone IMAGE:30378439), complete cds. CU688278 - Synthetic construct Homo sapiens gateway clone IMAGE:100023230 5' read POLR2A mRNA. KJ901650 - Synthetic construct Homo sapiens clone ccsbBroadEn_11044 POLR2A gene, encodes complete protein. LF326418 - JP 2014500723-A/133921: Polycomb-Associated Non-Coding RNAs. LF326417 - JP 2014500723-A/133920: Polycomb-Associated Non-Coding RNAs. M21610 - Human RNA polymerase II mRNA, 3' end of exon 5. LF326416 - JP 2014500723-A/133919: Polycomb-Associated Non-Coding RNAs. KX404973 - Homo sapiens isolate POLR2A_small_circ_F circular RNA circRNA, complete sequence. LF326414 - JP 2014500723-A/133917: Polycomb-Associated Non-Coding RNAs. LF326413 - JP 2014500723-A/133916: Polycomb-Associated Non-Coding RNAs. LF326412 - JP 2014500723-A/133915: Polycomb-Associated Non-Coding RNAs. LF326411 - JP 2014500723-A/133914: Polycomb-Associated Non-Coding RNAs. LF326410 - JP 2014500723-A/133913: Polycomb-Associated Non-Coding RNAs. LF209144 - JP 2014500723-A/16647: Polycomb-Associated Non-Coding RNAs. LF326408 - JP 2014500723-A/133911: Polycomb-Associated Non-Coding RNAs. LF326407 - JP 2014500723-A/133910: Polycomb-Associated Non-Coding RNAs. LF326406 - JP 2014500723-A/133909: Polycomb-Associated Non-Coding RNAs. LF326405 - JP 2014500723-A/133908: Polycomb-Associated Non-Coding RNAs. LF326404 - JP 2014500723-A/133907: Polycomb-Associated Non-Coding RNAs. LF326403 - JP 2014500723-A/133906: Polycomb-Associated Non-Coding RNAs. LF326402 - JP 2014500723-A/133905: Polycomb-Associated Non-Coding RNAs. LF326401 - JP 2014500723-A/133904: Polycomb-Associated Non-Coding RNAs. LF326400 - JP 2014500723-A/133903: Polycomb-Associated Non-Coding RNAs. LF326399 - JP 2014500723-A/133902: Polycomb-Associated Non-Coding RNAs. LF326398 - JP 2014500723-A/133901: Polycomb-Associated Non-Coding RNAs. MA561998 - JP 2018138019-A/133924: Polycomb-Associated Non-Coding RNAs. MA561995 - JP 2018138019-A/133921: Polycomb-Associated Non-Coding RNAs. MA561994 - JP 2018138019-A/133920: Polycomb-Associated Non-Coding RNAs. MA561993 - JP 2018138019-A/133919: Polycomb-Associated Non-Coding RNAs. MA561991 - JP 2018138019-A/133917: Polycomb-Associated Non-Coding RNAs. MA561990 - JP 2018138019-A/133916: Polycomb-Associated Non-Coding RNAs. MA561989 - JP 2018138019-A/133915: Polycomb-Associated Non-Coding RNAs. MA561988 - JP 2018138019-A/133914: Polycomb-Associated Non-Coding RNAs. MA561987 - JP 2018138019-A/133913: Polycomb-Associated Non-Coding RNAs. MA561985 - JP 2018138019-A/133911: Polycomb-Associated Non-Coding RNAs. MA561984 - JP 2018138019-A/133910: Polycomb-Associated Non-Coding RNAs. MA561983 - JP 2018138019-A/133909: Polycomb-Associated Non-Coding RNAs. MA561982 - JP 2018138019-A/133908: Polycomb-Associated Non-Coding RNAs. MA561981 - JP 2018138019-A/133907: Polycomb-Associated Non-Coding RNAs. MA561980 - JP 2018138019-A/133906: Polycomb-Associated Non-Coding RNAs. MA561979 - JP 2018138019-A/133905: Polycomb-Associated Non-Coding RNAs. MA561978 - JP 2018138019-A/133904: Polycomb-Associated Non-Coding RNAs. MA561977 - JP 2018138019-A/133903: Polycomb-Associated Non-Coding RNAs. MA561976 - JP 2018138019-A/133902: Polycomb-Associated Non-Coding RNAs. MA561975 - JP 2018138019-A/133901: Polycomb-Associated Non-Coding RNAs. MA444720 - JP 2018138019-A/16646: Polycomb-Associated Non-Coding RNAs. MA444721 - JP 2018138019-A/16647: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: A0A6Q8PGB0, A0A6Q8PGB0_HUMAN, ENST00000674977.1, NM_000937, POLR2A , uc329zbf.1, uc329zbf.2 UCSC ID: ENST00000674977.2_4 RefSeq Accession: NM_000937.5

Gene Model Information


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Methods, Credits, and Use Restrictions


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