ID:MPPB_HUMAN DESCRIPTION: RecName: Full=Mitochondrial-processing peptidase subunit beta; EC=3.4.24.64; AltName: Full=Beta-MPP; AltName: Full=P-52; Flags: Precursor; FUNCTION: Cleaves presequences (transit peptides) from mitochondrial protein precursors (By similarity). CATALYTIC ACTIVITY: Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2. COFACTOR: Binds 1 zinc ion per subunit (By similarity). SUBUNIT: Heterodimer of alpha and beta subunits (By similarity). SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity). SIMILARITY: Belongs to the peptidase M16 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75439
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c GO:0006508 proteolysis GO:0006627 protein processing involved in protein targeting to mitochondrion GO:0006851 mitochondrial calcium ion transport GO:0009060 aerobic respiration GO:0016485 protein processing
KJ901985 - Synthetic construct Homo sapiens clone ccsbBroadEn_11379 PMPCB gene, encodes complete protein. KJ901984 - Synthetic construct Homo sapiens clone ccsbBroadEn_11378 PMPCB gene, encodes complete protein. AK057656 - Homo sapiens cDNA FLJ33094 fis, clone TRACH2000703, highly similar to Mitochondrial-processing peptidase subunit beta, mitochondrial precursor (EC 3.4.24.64). AK000994 - Homo sapiens cDNA FLJ10132 fis, clone HEMBA1003046, highly similar to Mitochondrial-processing peptidase subunit beta, mitochondrial precursor (EC 3.4.24.64). AK289864 - Homo sapiens cDNA FLJ78497 complete cds. BC010398 - Homo sapiens peptidase (mitochondrial processing) beta, mRNA (cDNA clone IMAGE:4292383), with apparent retained intron. AF054182 - Homo sapiens mitochondrial processing peptidase beta-subunit mRNA, complete cds. AK309928 - Homo sapiens cDNA, FLJ99969. AK098616 - Homo sapiens cDNA FLJ25750 fis, clone TST06154, highly similar to MITOCHONDRIAL PROCESSING PEPTIDASE BETA SUBUNIT PRECURSOR (EC 3.4.24.64). AK297354 - Homo sapiens cDNA FLJ58513 complete cds, highly similar to Mitochondrial-processing peptidase subunit beta, mitochondrial precursor (EC 3.4.24.64). DQ896162 - Synthetic construct Homo sapiens clone IMAGE:100010622; FLH190772.01L; RZPDo839D1166D peptidase (mitochondrial processing) beta (PMPCB) gene, encodes complete protein. DQ892913 - Synthetic construct clone IMAGE:100005543; FLH190776.01X; RZPDo839D1176D peptidase (mitochondrial processing) beta (PMPCB) gene, encodes complete protein. BC014079 - Homo sapiens peptidase (mitochondrial processing) beta, mRNA (cDNA clone IMAGE:4309193), partial cds. CU680768 - Synthetic construct Homo sapiens gateway clone IMAGE:100019182 5' read PMPCB mRNA. AL050216 - Homo sapiens mRNA; cDNA DKFZp586I1223 (from clone DKFZp586I1223); partial cds. AK090763 - Homo sapiens cDNA FLJ33444 fis, clone BRALZ2000189. JD090998 - Sequence 72022 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O75439 (Reactome details) participates in the following event(s):
R-HSA-1299476 MPP cleaves targeting peptide (presequence) of inner membrane precursors R-HSA-1299478 MPP cleaves targeting peptide (presequence) of matrix precursors R-HSA-8949649 PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) R-HSA-1268020 Mitochondrial protein import R-HSA-8949664 Processing of SMDT1 R-HSA-392499 Metabolism of proteins R-HSA-8949215 Mitochondrial calcium ion transport R-HSA-382551 Transport of small molecules
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
