ID:PIN1_HUMAN DESCRIPTION: RecName: Full=Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; EC=5.2.1.8; AltName: Full=Peptidyl-prolyl cis-trans isomerase Pin1; Short=PPIase Pin1; AltName: Full=Rotamase Pin1; FUNCTION: Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0). SUBUNIT: Interacts with STIL (By similarity). Interacts with KIF20B. Interacts with NEK6. Interacts (via WW domain) with PRKX. Interacts with BTK. Interacts (via PpiC domain) with DAPK1. Interacts with the phosphorylated form of RAF1. Interacts (via WW domain) with ATCAY; upon NGF stimulation. INTERACTION: P05067-4:APP; NbExp=2; IntAct=EBI-714158, EBI-302641; Q15131:CDK10; NbExp=5; IntAct=EBI-714158, EBI-1646959; P51617:IRAK1; NbExp=10; IntAct=EBI-714158, EBI-358664; Q9HC98:NEK6; NbExp=3; IntAct=EBI-714158, EBI-740364; P46531:NOTCH1; NbExp=9; IntAct=EBI-714158, EBI-636374; P04637:TP53; NbExp=11; IntAct=EBI-714158, EBI-366083; SUBCELLULAR LOCATION: Nucleus. Nucleus speckle. Cytoplasm. Note=Co-localizes with NEK6 in the nucleus. Mainly localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization. TISSUE SPECIFICITY: The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells. DOMAIN: The WW domain is required for the interaction with STIL and KIF20B. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylation at Ser-71 by DAPK1 results in inhibition of its catalytic activity, nuclear localization, and its ability to induce centrosome amplification, chromosome instability and cell transformation. SIMILARITY: Contains 1 PpiC domain. SIMILARITY: Contains 1 WW domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13526
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000413 protein peptidyl-prolyl isomerization GO:0001934 positive regulation of protein phosphorylation GO:0007049 cell cycle GO:0007088 regulation of mitotic nuclear division GO:0030182 neuron differentiation GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway GO:0032091 negative regulation of protein binding GO:0032465 regulation of cytokinesis GO:0032480 negative regulation of type I interferon production GO:0035307 positive regulation of protein dephosphorylation GO:0042177 negative regulation of protein catabolic process GO:0043524 negative regulation of neuron apoptotic process GO:0043525 positive regulation of neuron apoptotic process GO:0043547 positive regulation of GTPase activity GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0050808 synapse organization GO:0050821 protein stabilization GO:0051443 positive regulation of ubiquitin-protein transferase activity GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development GO:0070373 negative regulation of ERK1 and ERK2 cascade GO:0090263 positive regulation of canonical Wnt signaling pathway GO:1900180 regulation of protein localization to nucleus GO:1901796 regulation of signal transduction by p53 class mediator GO:2000146 negative regulation of cell motility GO:0046785 microtubule polymerization
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
