Human Gene PIK3C2G (ENST00000538779.6_6) from GENCODE V47lift37
  Description: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma, transcript variant 2 (from RefSeq NM_001288774.2)
Gencode Transcript: ENST00000538779.6_6
Gencode Gene: ENSG00000139144.11_9
Transcript (Including UTRs)
   Position: hg19 chr12:18,414,452-18,801,350 Size: 386,899 Total Exon Count: 33 Strand: +
Coding Region
   Position: hg19 chr12:18,435,016-18,800,962 Size: 365,947 Coding Exon Count: 32 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:18,414,452-18,801,350)mRNA (may differ from genome)Protein (1486 aa)
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HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: P3C2G_HUMAN
DESCRIPTION: RecName: Full=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; Short=PI3K-C2-gamma; Short=PtdIns-3-kinase C2 subunit gamma; EC=2.7.1.154; AltName: Full=Phosphoinositide 3-kinase-C2-gamma;
FUNCTION: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity).
CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein (By similarity).
TISSUE SPECIFICITY: Highly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and pancreas.
SIMILARITY: Belongs to the PI3/PI4-kinase family.
SIMILARITY: Contains 1 C2 domain.
SIMILARITY: Contains 1 C2 PI3K-type domain.
SIMILARITY: Contains 1 PI3K-RBD domain.
SIMILARITY: Contains 1 PI3K/PI4K domain.
SIMILARITY: Contains 1 PIK helical domain.
SIMILARITY: Contains 1 PX (phox homology) domain.
SEQUENCE CAUTION: Sequence=CAA03853.1; Type=Erroneous termination; Positions=1446; Note=Translated as stop;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.93 RPKM in Stomach
Total median expression: 25.51 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -27.20138-0.197 Picture PostScript Text
3' UTR -68.80388-0.177 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016024 - ARM-type_fold
IPR000008 - C2_Ca-dep
IPR008973 - C2_Ca/lipid-bd_dom_CaLB
IPR011009 - Kinase-like_dom
IPR001683 - Phox
IPR000403 - PI3/4_kinase_cat_dom
IPR018936 - PI3/4_kinase_CS
IPR002420 - PI3K_C2_dom
IPR000341 - PI3K_Ras-bd_dom
IPR015433 - PI_Kinase
IPR001263 - PInositide-3_kin_accessory_dom

Pfam Domains:
PF00168 - C2 domain
PF00454 - Phosphatidylinositol 3- and 4-kinase
PF00613 - Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PF00787 - PX domain
PF00792 - Phosphoinositide 3-kinase C2
PF00794 - PI3-kinase family, ras-binding domain

SCOP Domains:
48371 - ARM repeat
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
56112 - Protein kinase-like (PK-like)
54236 - Ubiquitin-like
64268 - PX domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2WWE - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on O75747
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016307 phosphatidylinositol phosphate kinase activity
GO:0016740 transferase activity
GO:0035004 phosphatidylinositol 3-kinase activity
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035091 phosphatidylinositol binding

Biological Process:
GO:0006935 chemotaxis
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0039694 viral RNA genome replication
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  AJ000008 - Homo sapiens mRNA for C2 domain containing PI3-kinase.
BC130277 - Homo sapiens phosphoinositide-3-kinase, class 2, gamma polypeptide, mRNA (cDNA clone MGC:163149 IMAGE:40146308), complete cds.
BC144133 - Homo sapiens cDNA clone IMAGE:9052653.
BC144134 - Homo sapiens phosphoinositide-3-kinase, class 2, gamma polypeptide, mRNA (cDNA clone MGC:177671 IMAGE:9052654), complete cds.
JD298983 - Sequence 280007 from Patent EP1572962.
JD080632 - Sequence 61656 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-6352 - 3-phosphoinositide biosynthesis
PWY-6371 - superpathway of inositol phosphate compounds

BioCarta from NCI Cancer Genome Anatomy Project
h_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells
h_CCR3Pathway - CCR3 signaling in Eosinophils
h_cxcr4Pathway - CXCR4 Signaling Pathway

Reactome (by CSHL, EBI, and GO)

Protein O75747 (Reactome details) participates in the following event(s):

R-HSA-1676109 PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
R-HSA-1675928 PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane
R-HSA-1483255 PI Metabolism
R-HSA-1483257 Phospholipid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: A1L3U0, ENST00000538779.1, ENST00000538779.2, ENST00000538779.3, ENST00000538779.4, ENST00000538779.5, F5H369, NM_001288774, O75747, P3C2G_HUMAN, uc324qtq.1, uc324qtq.2
UCSC ID: ENST00000538779.6_6
RefSeq Accession: NM_001288772.2
Protein: O75747 (aka P3C2G_HUMAN or PK3G_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.