Human Gene PIGR (ENST00000356495.5_7) from GENCODE V47lift37

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Description: polymeric immunoglobulin receptor (from RefSeq NM_002644.4)
Gencode Transcript: ENST00000356495.5_7
Gencode Gene: ENSG00000162896.6_9
Transcript (Including UTRs)
Position: hg19 chr1:207,101,867-207,119,811 Size: 17,945 Total Exon Count: 11 Strand: -
Coding Region
Position: hg19 chr1:207,103,663-207,113,876 Size: 10,214 Coding Exon Count: 10

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:207,101,867-207,119,811)			mRNA (may differ from genome)		Protein (764 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: PIGR_HUMAN DESCRIPTION: RecName: Full=Polymeric immunoglobulin receptor; Short=PIgR; Short=Poly-Ig receptor; AltName: Full=Hepatocellular carcinoma-associated protein TB6; Contains: RecName: Full=Secretory component; Flags: Precursor; FUNCTION: This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Secretory component: Secreted. PTM: N-glycosylation is not necessary for Ig binding. SIMILARITY: Contains 5 Ig-like V-type (immunoglobulin-like) domains.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: PIGR Diseases sorted by gene-association score: periampullary adenocarcinoma (23), protein-energy malnutrition (11), nasopharyngeal carcinoma (3)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C006253 pirinixic acid C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene C016403 2,4-dinitrotoluene C028451 3,4,3',4'-tetrachlorobiphenyl C009505 4,4'-diaminodiphenylmethane D000082 Acetaminophen D016604 Aflatoxin B1 D019386 Alendronate D000643 Ammonium Chloride D001564 Benzo(a)pyrene more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 999.59 RPKM in Colon - Transverse Total median expression: 2189.93 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-59.60	184	-0.324	Picture	PostScript	Text
3' UTR	-585.30	1796	-0.326	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR013106 - Ig_V-set

Pfam Domains:
PF07686 - Immunoglobulin V-set domain

SCOP Domains:
48726 - Immunoglobulin

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1XED - X-ray MuPIT

2OCW - X-ray MuPIT

3CHN - Other

3CM9 - Other

ModBase Predicted Comparative 3D Structure on P01833


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0001792 polymeric immunoglobulin receptor activity Biological Process: GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste GO:0001895 retina homeostasis GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor GO:0007173 epidermal growth factor receptor signaling pathway GO:0038093 Fc receptor signaling pathway GO:0043113 receptor clustering GO:0043312 neutrophil degranulation Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space GO:0005886 plasma membrane GO:0005887 integral component of plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0035577 azurophil granule membrane GO:0043235 receptor complex GO:0070062 extracellular exosome

Descriptions from all associated GenBank mRNAs


	KJ891807 - Synthetic construct Homo sapiens clone ccsbBroadEn_01201 PIGR gene, encodes complete protein. KR711813 - Synthetic construct Homo sapiens clone CCSBHm_00031134 PIGR (PIGR) mRNA, encodes complete protein. LF205335 - JP 2014500723-A/12838: Polycomb-Associated Non-Coding RNAs. AK026320 - Homo sapiens cDNA: FLJ22667 fis, clone HSI08385. AY178835 - Homo sapiens polymeric immunoglobulin receptor (PIGR) mRNA, 3' untranslated region. CR749533 - Homo sapiens mRNA; cDNA DKFZp686I21225 (from clone DKFZp686I21225). AK225471 - Homo sapiens mRNA for polymeric immunoglobulin receptor variant, clone: HSI13542. AF272149 - Homo sapiens hepatocellular carcinoma associated protein TB6 mRNA, complete cds. JD181435 - Sequence 162459 from Patent EP1572962. JD103764 - Sequence 84788 from Patent EP1572962. JD458202 - Sequence 439226 from Patent EP1572962. JD215743 - Sequence 196767 from Patent EP1572962. JD062974 - Sequence 43998 from Patent EP1572962. JD299467 - Sequence 280491 from Patent EP1572962. JD109845 - Sequence 90869 from Patent EP1572962. JD528192 - Sequence 509216 from Patent EP1572962. JD334498 - Sequence 315522 from Patent EP1572962. JD509593 - Sequence 490617 from Patent EP1572962. JD509788 - Sequence 490812 from Patent EP1572962. JD289820 - Sequence 270844 from Patent EP1572962. JD164543 - Sequence 145567 from Patent EP1572962. JD072982 - Sequence 54006 from Patent EP1572962. JD414650 - Sequence 395674 from Patent EP1572962. JD459784 - Sequence 440808 from Patent EP1572962. JD255558 - Sequence 236582 from Patent EP1572962. JD456228 - Sequence 437252 from Patent EP1572962. AK310199 - Homo sapiens cDNA, FLJ17241. JD504933 - Sequence 485957 from Patent EP1572962. JD203731 - Sequence 184755 from Patent EP1572962. JD362501 - Sequence 343525 from Patent EP1572962. JD466299 - Sequence 447323 from Patent EP1572962. JD070700 - Sequence 51724 from Patent EP1572962. JD499731 - Sequence 480755 from Patent EP1572962. JD489163 - Sequence 470187 from Patent EP1572962. JD374547 - Sequence 355571 from Patent EP1572962. JD419530 - Sequence 400554 from Patent EP1572962. JD212888 - Sequence 193912 from Patent EP1572962. JD407500 - Sequence 388524 from Patent EP1572962. JD526237 - Sequence 507261 from Patent EP1572962. JD352921 - Sequence 333945 from Patent EP1572962. JD427665 - Sequence 408689 from Patent EP1572962. JD061278 - Sequence 42302 from Patent EP1572962. JD063580 - Sequence 44604 from Patent EP1572962. JD107570 - Sequence 88594 from Patent EP1572962. JD505848 - Sequence 486872 from Patent EP1572962. JD356385 - Sequence 337409 from Patent EP1572962. JD374625 - Sequence 355649 from Patent EP1572962. JD252650 - Sequence 233674 from Patent EP1572962. JD039787 - Sequence 20811 from Patent EP1572962. JD145729 - Sequence 126753 from Patent EP1572962. S62403 - transmembrane secretory component [human, colonic adenocarcinoma cell line HT29.E100, mRNA, 2898 nt]. M24559 - Human poly-Ig receptor transmembrane secretory component mRNA, 3' end. X73079 - Homo sapiens mRNA for Polymeric immunoglobulin receptor. JD163657 - Sequence 144681 from Patent EP1572962. JD385976 - Sequence 367000 from Patent EP1572962. JD366845 - Sequence 347869 from Patent EP1572962. JD385975 - Sequence 366999 from Patent EP1572962. JD300013 - Sequence 281037 from Patent EP1572962. JD342950 - Sequence 323974 from Patent EP1572962. JD445405 - Sequence 426429 from Patent EP1572962. JD493619 - Sequence 474643 from Patent EP1572962. JD131916 - Sequence 112940 from Patent EP1572962. JD414149 - Sequence 395173 from Patent EP1572962. JD439534 - Sequence 420558 from Patent EP1572962. JD522649 - Sequence 503673 from Patent EP1572962. JD377375 - Sequence 358399 from Patent EP1572962. JD227676 - Sequence 208700 from Patent EP1572962. BC110494 - Homo sapiens polymeric immunoglobulin receptor, mRNA (cDNA clone MGC:125361 IMAGE:40007650), complete cds. BC110495 - Homo sapiens polymeric immunoglobulin receptor, mRNA (cDNA clone MGC:125362 IMAGE:40007652), complete cds. AB590629 - Synthetic construct DNA, clone: pFN21AE2089, Homo sapiens PIGR gene for polymeric immunoglobulin receptor, without stop codon, in Flexi system. AK309273 - Homo sapiens cDNA, FLJ99314. JD135071 - Sequence 116095 from Patent EP1572962. JD270857 - Sequence 251881 from Patent EP1572962. JD468850 - Sequence 449874 from Patent EP1572962. JD488859 - Sequence 469883 from Patent EP1572962. JD475241 - Sequence 456265 from Patent EP1572962. JD106513 - Sequence 87537 from Patent EP1572962. JD187479 - Sequence 168503 from Patent EP1572962. JD560424 - Sequence 541448 from Patent EP1572962. MA440912 - JP 2018138019-A/12838: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein P01833 (Reactome details) participates in the following event(s): R-HSA-6798739 Exocytosis of azurophil granule membrane proteins R-HSA-6798695 Neutrophil degranulation R-HSA-168249 Innate Immune System R-HSA-168256 Immune System

Other Names for This Gene


	Alternate Gene Symbols: ENST00000356495.1, ENST00000356495.2, ENST00000356495.3, ENST00000356495.4, NM_002644, P01833, PIGR_HUMAN, Q68D81, Q8IZY7, uc317zov.1, uc317zov.2 UCSC ID: ENST00000356495.5_7 RefSeq Accession: NM_002644.4 Protein: P01833 (aka PIGR_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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