Human Gene PIGB (ENST00000164305.10_6) from GENCODE V47lift37

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Description: phosphatidylinositol glycan anchor biosynthesis class B (from RefSeq NM_004855.5)
Gencode Transcript: ENST00000164305.10_6
Gencode Gene: ENSG00000069943.10_10
Transcript (Including UTRs)
Position: hg19 chr15:55,611,420-55,647,846 Size: 36,427 Total Exon Count: 12 Strand: +
Coding Region
Position: hg19 chr15:55,611,449-55,647,630 Size: 36,182 Coding Exon Count: 12

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr15:55,611,420-55,647,846)			mRNA (may differ from genome)		Protein (554 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: PIGB_HUMAN DESCRIPTION: RecName: Full=GPI mannosyltransferase 3; EC=2.4.1.-; AltName: Full=GPI mannosyltransferase III; Short=GPI-MT-III; AltName: Full=Phosphatidylinositol-glycan biosynthesis class B protein; Short=PIG-B; FUNCTION: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly. PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the glycosyltransferase 22 family. PIGB subfamily.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C023514 2,6-dinitrotoluene D001564 Benzo(a)pyrene D002794 Choline D019327 Copper Sulfate D016572 Cyclosporine D005492 Folic Acid D007545 Isoproterenol C568376 MT19c compound D008715 Methionine D008727 Methotrexate more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 6.14 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 147.44 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-8.90	29	-0.307	Picture	PostScript	Text
3' UTR	-30.80	216	-0.143	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR005599 - GPI_mannosylTrfase

Pfam Domains:
PF03901 - Alg9-like mannosyltransferase family

ModBase Predicted Comparative 3D Structure on Q92521


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser
Gene Details	Gene Details		Gene Details	Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase	SGD
					Protein Sequence
					Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000030 mannosyltransferase activity GO:0004376 glycolipid mannosyltransferase activity GO:0016740 transferase activity GO:0016757 transferase activity, transferring glycosyl groups Biological Process: GO:0006506 GPI anchor biosynthetic process GO:0016254 preassembly of GPI anchor in ER membrane GO:0097502 mannosylation Cellular Component: GO:0005783 endoplasmic reticulum GO:0005789 endoplasmic reticulum membrane GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	LF384572 - JP 2014500723-A/192075: Polycomb-Associated Non-Coding RNAs. AK314706 - Homo sapiens cDNA, FLJ95561, highly similar to Homo sapiens phosphatidylinositol glycan, class B (PIGB), mRNA. AK293666 - Homo sapiens cDNA FLJ57717 complete cds, highly similar to GPI mannosyltransferase 3 (EC 2.4.1.-). BC017711 - Homo sapiens phosphatidylinositol glycan anchor biosynthesis, class B, mRNA (cDNA clone MGC:21236 IMAGE:4430974), complete cds. JD406886 - Sequence 387910 from Patent EP1572962. D42138 - Homo sapiens mRNA for PIG-B, complete cds. JD552035 - Sequence 533059 from Patent EP1572962. AK223330 - Homo sapiens mRNA for phosphatidylinositol glycan, class B variant, clone: TST01103. JD241494 - Sequence 222518 from Patent EP1572962. KJ898033 - Synthetic construct Homo sapiens clone ccsbBroadEn_07427 PIGB gene, encodes complete protein. AK093138 - Homo sapiens cDNA FLJ35819 fis, clone TESTI2006179, highly similar to Homo sapiens mRNA for PIG-B. LF384570 - JP 2014500723-A/192073: Polycomb-Associated Non-Coding RNAs. JD092463 - Sequence 73487 from Patent EP1572962. JD273068 - Sequence 254092 from Patent EP1572962. MA620149 - JP 2018138019-A/192075: Polycomb-Associated Non-Coding RNAs. MA620147 - JP 2018138019-A/192073: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q92521 (Reactome details) participates in the following event(s): R-HSA-162821 mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate R-HSA-162710 Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins

Other Names for This Gene


	Alternate Gene Symbols: ENST00000164305.1, ENST00000164305.2, ENST00000164305.3, ENST00000164305.4, ENST00000164305.5, ENST00000164305.6, ENST00000164305.7, ENST00000164305.8, ENST00000164305.9, NM_004855, PIGB , PIGB_HUMAN, Q53FF9, Q8WVN7, Q92521, uc317cdb.1, uc317cdb.2 UCSC ID: ENST00000164305.10_6 RefSeq Accession: NM_004855.5 Protein: Q92521 (aka PIGB_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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