ID:PHC2_HUMAN DESCRIPTION: RecName: Full=Polyhomeotic-like protein 2; Short=hPH2; AltName: Full=Early development regulatory protein 2; FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. SUBUNIT: Component of a PRC1-like complex. Interacts with CBX4. Interacts with BMI1, PCGF2, PHC1 and RNF2 (By similarity). Interacts with N-terminal region of the SP1 transcription factor and with MAPKAPK2. INTERACTION: Q96EZ8:MCRS1; NbExp=2; IntAct=EBI-713786, EBI-348259; P53350:PLK1; NbExp=2; IntAct=EBI-713786, EBI-476768; P08047:SP1; NbExp=2; IntAct=EBI-713786, EBI-298336; SUBCELLULAR LOCATION: Nucleus. DOMAIN: HD1 motif interacts with SAM domain of PHC1. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. MISCELLANEOUS: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes. SIMILARITY: Contains 1 FCS-type zinc finger. SIMILARITY: Contains 1 SAM (sterile alpha motif) domain. SEQUENCE CAUTION: Sequence=AAH68573.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH92492.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAI13956.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00536 - SAM domain (Sterile alpha motif) PF07647 - SAM domain (Sterile alpha motif) PF16616 - Unstructured region on Polyhomeotic-like protein 1 and 2
ModBase Predicted Comparative 3D Structure on Q8IXK0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
