ID:PDS5B_HUMAN DESCRIPTION: RecName: Full=Sister chromatid cohesion protein PDS5 homolog B; AltName: Full=Androgen-induced proliferation inhibitor; AltName: Full=Androgen-induced prostate proliferative shutoff-associated protein AS3; FUNCTION: Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. SUBUNIT: Interacts with the cohesin complex. Interacts with RAD21; the interaction is direct. Interacts with WAPAL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin- dependent and competitive (Probable). INTERACTION: O60216:RAD21; NbExp=3; IntAct=EBI-1175604, EBI-80739; Q9UQE7:SMC3; NbExp=6; IntAct=EBI-1175604, EBI-80718; Q8WVM7:STAG1; NbExp=3; IntAct=EBI-1175604, EBI-1175097; Q8N3U4:STAG2; NbExp=3; IntAct=EBI-1175604, EBI-1057252; Q7Z5K2:WAPAL; NbExp=9; IntAct=EBI-1175604, EBI-1022242; SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Widely expressed. INDUCTION: By the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest. Maximum levels occur 18-20 hours after androgen exposure. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the PDS5 family. SIMILARITY: Contains 3 A.T hook DNA-binding domains. SIMILARITY: Contains 1 HEAT repeat. SEQUENCE CAUTION: Sequence=BAA76823.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NTI5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
