Human Gene PDRG1 (ENST00000202017.6_7) from GENCODE V47lift37
  Description: p53 and DNA damage regulated 1 (from RefSeq NM_030815.3)
Gencode Transcript: ENST00000202017.6_7
Gencode Gene: ENSG00000088356.6_9
Transcript (Including UTRs)
   Position: hg19 chr20:30,532,140-30,539,849 Size: 7,710 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr20:30,533,610-30,539,764 Size: 6,155 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:30,532,140-30,539,849)mRNA (may differ from genome)Protein (133 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PDRG1_HUMAN
DESCRIPTION: RecName: Full=p53 and DNA damage-regulated protein 1;
FUNCTION: May play a role in chaperone-mediated protein folding (Potential).
SUBCELLULAR LOCATION: Cytoplasm (Potential).
TISSUE SPECIFICITY: Predominantly expressed in normal testis and exhibits reduced but detectable expression in other organs.
INDUCTION: By UV irradiation and repressed by p53/TP53.
SIMILARITY: Belongs to the prefoldin subunit beta family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C010914 2,4-diaminotoluene
  • C016403 2,4-dinitrotoluene
  • C023514 2,6-dinitrotoluene
  • C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
  • D016604 Aflatoxin B1
  • D017638 Asbestos, Crocidolite
  • D001564 Benzo(a)pyrene
  • D019327 Copper Sulfate
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 42.24 RPKM in Testis
Total median expression: 537.54 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -34.9085-0.411 Picture PostScript Text
3' UTR -501.201470-0.341 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002777 - PFD_beta-like

Pfam Domains:
PF01920 - Prefoldin subunit

SCOP Domains:
46579 - Prefoldin

ModBase Predicted Comparative 3D Structure on Q9NUG6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0051082 unfolded protein binding

Biological Process:
GO:0006457 protein folding

Cellular Component:
GO:0005737 cytoplasm
GO:0016272 prefoldin complex


-  Descriptions from all associated GenBank mRNAs
  BC009334 - Homo sapiens p53 and DNA damage regulated 1, mRNA (cDNA clone MGC:16693 IMAGE:4126826), complete cds.
AY286301 - Homo sapiens p53 and DNA damage-regulated protein (PDRG) mRNA, complete cds.
AK312021 - Homo sapiens cDNA, FLJ92297.
JD045536 - Sequence 26560 from Patent EP1572962.
JD237376 - Sequence 218400 from Patent EP1572962.
JD091308 - Sequence 72332 from Patent EP1572962.
BC001856 - Homo sapiens p53 and DNA damage regulated 1, mRNA (cDNA clone IMAGE:3528151), partial cds.
JD548351 - Sequence 529375 from Patent EP1572962.
JD079881 - Sequence 60905 from Patent EP1572962.
JD186480 - Sequence 167504 from Patent EP1572962.
JD535189 - Sequence 516213 from Patent EP1572962.
JD164434 - Sequence 145458 from Patent EP1572962.
JD185906 - Sequence 166930 from Patent EP1572962.
JD334979 - Sequence 316003 from Patent EP1572962.
JD021388 - Sequence 2412 from Patent EP1572962.
JD028579 - Sequence 9603 from Patent EP1572962.
JD555603 - Sequence 536627 from Patent EP1572962.
JD481704 - Sequence 462728 from Patent EP1572962.
JD340315 - Sequence 321339 from Patent EP1572962.
JD481753 - Sequence 462777 from Patent EP1572962.
JD073893 - Sequence 54917 from Patent EP1572962.
JD355084 - Sequence 336108 from Patent EP1572962.
JD513190 - Sequence 494214 from Patent EP1572962.
JD171801 - Sequence 152825 from Patent EP1572962.
JD307286 - Sequence 288310 from Patent EP1572962.
JD195032 - Sequence 176056 from Patent EP1572962.
JD432760 - Sequence 413784 from Patent EP1572962.
JD154541 - Sequence 135565 from Patent EP1572962.
JD307306 - Sequence 288330 from Patent EP1572962.
JD123948 - Sequence 104972 from Patent EP1572962.
GQ891341 - Homo sapiens clone HEL-S-112d epididymis secretory sperm binding protein mRNA, complete cds.
KJ894847 - Synthetic construct Homo sapiens clone ccsbBroadEn_04241 PDRG1 gene, encodes complete protein.
AB528566 - Synthetic construct DNA, clone: pF1KE1001, Homo sapiens PDRG1 gene for p53 and DNA-damage regulated protein 1, without stop codon, in Flexi system.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R511, C20orf126, ENST00000202017.1, ENST00000202017.2, ENST00000202017.3, ENST00000202017.4, ENST00000202017.5, NM_030815, PDRG, PDRG1_HUMAN, Q96GP3, Q9BUW8, Q9NUG6, uc317cij.1, uc317cij.2
UCSC ID: ENST00000202017.6_7
RefSeq Accession: NM_030815.3
Protein: Q9NUG6 (aka PDRG1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.