ID:PCSK7_HUMAN DESCRIPTION: RecName: Full=Proprotein convertase subtilisin/kexin type 7; EC=3.4.21.-; AltName: Full=Lymphoma proprotein convertase; AltName: Full=Prohormone convertase 7; AltName: Full=Proprotein convertase 7; Short=PC7; AltName: Full=Proprotein convertase 8; Short=PC8; Short=hPC8; AltName: Full=Subtilisin/kexin-like protease PC7; Flags: Precursor; FUNCTION: Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif. CATALYTIC ACTIVITY: Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Xaa-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. COFACTOR: Calcium (By similarity). ENZYME REGULATION: Inhibited by zinc and copper (By similarity). SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein (By similarity). Note=Seems to be localized intracellularly to the trans Golgi network (By similarity). TISSUE SPECIFICITY: Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. PTM: Cysteine residues in the cytoplasmic tail are probably palmitoylated. PTM: N-glycosylated. SIMILARITY: Belongs to the peptidase S8 family. SIMILARITY: Contains 1 homo B/P domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16549
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.