ID:PCGF2_HUMAN DESCRIPTION: RecName: Full=Polycomb group RING finger protein 2; AltName: Full=DNA-binding protein Mel-18; AltName: Full=RING finger protein 110; AltName: Full=Zinc finger protein 144; FUNCTION: Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero- posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with Bmi1; unlike Bmi1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex (By similarity). SUBUNIT: Exists as both a monomer and homodimer (By similarity). Component of a PRC1-like complex. Interacts WITH CBX8, RING1 AND RNF2. INTERACTION: O95931:CBX7; NbExp=3; IntAct=EBI-2129767, EBI-3923843; Q9HC52:CBX8; NbExp=6; IntAct=EBI-2129767, EBI-712912; Q06587:RING1; NbExp=4; IntAct=EBI-2129767, EBI-752313; Q99496:RNF2; NbExp=6; IntAct=EBI-2129767, EBI-722416; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Detected in all tissues examined with high expression found in placenta lung and kidney and low expression, in liver, pancreas and skeletal muscle. PTM: Phosphorylated. Homodimer formation is regulated by phosphorylation state with unphosphorylated protein forming homodimers (By similarity). SIMILARITY: Contains 1 RING-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P35227
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
D13969 - Homo sapiens mRNA for Mel-18 protein, complete cds. JD080134 - Sequence 61158 from Patent EP1572962. JD288039 - Sequence 269063 from Patent EP1572962. JD107194 - Sequence 88218 from Patent EP1572962. JD302013 - Sequence 283037 from Patent EP1572962. JD300118 - Sequence 281142 from Patent EP1572962. JD037633 - Sequence 18657 from Patent EP1572962. JD133477 - Sequence 114501 from Patent EP1572962. JD274824 - Sequence 255848 from Patent EP1572962. JD446733 - Sequence 427757 from Patent EP1572962. JD081408 - Sequence 62432 from Patent EP1572962. JD386331 - Sequence 367355 from Patent EP1572962. JD253169 - Sequence 234193 from Patent EP1572962. JD418408 - Sequence 399432 from Patent EP1572962. JD129946 - Sequence 110970 from Patent EP1572962. JD416057 - Sequence 397081 from Patent EP1572962. JD556938 - Sequence 537962 from Patent EP1572962. JD303713 - Sequence 284737 from Patent EP1572962. BC004858 - Homo sapiens polycomb group ring finger 2, mRNA (cDNA clone MGC:10336 IMAGE:3841545), complete cds. BC024255 - Homo sapiens polycomb group ring finger 2, mRNA (cDNA clone MGC:10545 IMAGE:3605568), complete cds. BX647429 - Homo sapiens mRNA; cDNA DKFZp686A11149 (from clone DKFZp686A11149). JD556652 - Sequence 537676 from Patent EP1572962. JD188785 - Sequence 169809 from Patent EP1572962. JD556580 - Sequence 537604 from Patent EP1572962. KJ892417 - Synthetic construct Homo sapiens clone ccsbBroadEn_01811 PCGF2 gene, encodes complete protein. AB464037 - Synthetic construct DNA, clone: pF1KB8358, Homo sapiens PCGF2 gene for polycomb group ring finger 2, without stop codon, in Flexi system. AM392769 - Synthetic construct Homo sapiens clone IMAGE:100002497 for hypothetical protein (PCGF2 gene).
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P35227 (Reactome details) participates in the following event(s):
R-HSA-4551727 CBX4 SUMOylates CBX4 in PRC1 with SUMO1 R-HSA-4551655 CBX4 SUMOylates BMI1 in PRC1 with SUMO1 R-HSA-8954082 E2F6 binds the PRC1 complex R-HSA-4570463 CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 R-HSA-4570499 CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-4551638 SUMOylation of chromatin organization proteins R-HSA-5619507 Activation of HOX genes during differentiation R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins R-HSA-8953750 Transcriptional Regulation by E2F6 R-HSA-1266738 Developmental Biology R-HSA-2990846 SUMOylation R-HSA-3108214 SUMOylation of DNA damage response and repair proteins R-HSA-4570464 SUMOylation of RNA binding proteins R-HSA-212436 Generic Transcription Pathway R-HSA-597592 Post-translational protein modification R-HSA-73857 RNA Polymerase II Transcription R-HSA-392499 Metabolism of proteins R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
