ID:PCBP2_HUMAN DESCRIPTION: RecName: Full=Poly(rC)-binding protein 2; AltName: Full=Alpha-CP2; AltName: Full=Heterogeneous nuclear ribonucleoprotein E2; Short=hnRNP E2; FUNCTION: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation. SUBUNIT: Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with IFIH1 and RNF135. Interacts with MAVS (via C-terminus) and ITCH (via WW domains). INTERACTION: Q15365:PCBP1; NbExp=2; IntAct=EBI-945799, EBI-946095; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm. TISSUE SPECIFICITY: Detected in all tissues examined. DOMAIN: The KH domains mediates poly(C) binding. PTM: Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity. SIMILARITY: Contains 3 KH domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15366
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000398 mRNA splicing, via spliceosome GO:0002376 immune system process GO:0016070 RNA metabolic process GO:0016071 mRNA metabolic process GO:0032480 negative regulation of type I interferon production GO:0039694 viral RNA genome replication GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0045087 innate immune response GO:0050687 negative regulation of defense response to virus GO:0051607 defense response to virus GO:0075522 IRES-dependent viral translational initiation
AB188306 - Homo sapiens PCBP2 mRNA for poly(rC) binding protein 2, complete cds. BC071942 - Homo sapiens poly(rC) binding protein 2, mRNA (cDNA clone MGC:88629 IMAGE:6424433), complete cds. GQ900927 - Homo sapiens clone HEL-T-39 epididymis secretory sperm binding protein mRNA, complete cds. BC035420 - Homo sapiens poly(rC) binding protein 2, mRNA (cDNA clone IMAGE:3858119). AK292141 - Homo sapiens cDNA FLJ77432 complete cds, highly similar to Homo sapiens poly(rC) binding protein 2 (PCBP2), transcript variant 2, mRNA. BC001155 - Homo sapiens poly(rC) binding protein 2, mRNA (cDNA clone MGC:1457 IMAGE:3356341), complete cds. AB208825 - Homo sapiens mRNA for poly(rC)-binding protein 2 isoform b variant protein. AK302067 - Homo sapiens cDNA FLJ58339 complete cds, highly similar to Poly(rC)-binding protein 2. AK225357 - Homo sapiens mRNA for poly(rC)-binding protein 2 isoform b variant, clone: HEP17609. X78136 - H.sapiens hnRNP-E2 mRNA. BC107688 - Homo sapiens poly(rC) binding protein 2, mRNA (cDNA clone MGC:110998 IMAGE:5395926), complete cds. AB464035 - Synthetic construct DNA, clone: pF1KB3111, Homo sapiens PCBP2 gene for poly(rC) binding protein 2, without stop codon, in Flexi system. AK299210 - Homo sapiens cDNA FLJ54752 complete cds, highly similar to Poly(rC)-binding protein 2. AK023529 - Homo sapiens cDNA FLJ13467 fis, clone PLACE1003519, highly similar to H.sapiens hnRNP-E2 mRNA. AK130583 - Homo sapiens cDNA FLJ27073 fis, clone SPL02032, highly similar to POLY(RC) BINDING PROTEIN 2. AK123458 - Homo sapiens cDNA FLJ41464 fis, clone BRSTN2017379, highly similar to POLY(RC) BINDING PROTEIN 2. AK296930 - Homo sapiens cDNA FLJ58476 complete cds, highly similar to Poly(rC)-binding protein 2. JD438797 - Sequence 419821 from Patent EP1572962. JD094045 - Sequence 75069 from Patent EP1572962. JD253011 - Sequence 234035 from Patent EP1572962. KF041153 - Homo sapiens lncRNA (TUC338) gene, complete sequence. AY952882 - Homo sapiens antigen MMSA-2 mRNA sequence. JD329896 - Sequence 310920 from Patent EP1572962. JD019843 - Sequence 867 from Patent EP1572962. JD027925 - Sequence 8949 from Patent EP1572962. JD027513 - Sequence 8537 from Patent EP1572962. JD187986 - Sequence 169010 from Patent EP1572962. JD034548 - Sequence 15572 from Patent EP1572962. LQ655962 - Sequence 20 from Patent EP3081645. CU690633 - Synthetic construct Homo sapiens gateway clone IMAGE:100020929 3' read MAP3K12 mRNA.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q15366 (Reactome details) participates in the following event(s):
R-HSA-72103 Formation of pre-mRNPs R-HSA-990528 Interaction of PCBP2 with MAVS R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-990526 Recruitment of AIP4 and K48 ubiquitination of MAVS/IPS-1 R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling R-HSA-8953854 Metabolism of RNA R-HSA-72172 mRNA Splicing R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168249 Innate Immune System R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
