Human Gene PATZ1 (ENST00000215919.3_5) from GENCODE V47lift37
  Description: POZ/BTB and AT hook containing zinc finger 1, transcript variant 4 (from RefSeq NM_032051.2)
Gencode Transcript: ENST00000215919.3_5
Gencode Gene: ENSG00000100105.18_10
Transcript (Including UTRs)
   Position: hg19 chr22:31,736,663-31,741,762 Size: 5,100 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr22:31,737,391-31,741,588 Size: 4,198 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:31,736,663-31,741,762)mRNA (may differ from genome)Protein (537 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q9HD72_HUMAN
DESCRIPTION: SubName: Full=Krueppel-related zinc finger protein SBZF5;
SIMILARITY: Contains 1 BTB (POZ) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PATZ1
Diseases sorted by gene-association score: sarcoma (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.84 RPKM in Thyroid
Total median expression: 358.93 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -77.50174-0.445 Picture PostScript Text
3' UTR -271.70728-0.373 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017956 - AT_hook_DNA-bd_motif
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR000637 - HMGI/Y_DNA-bd_CS
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF00651 - BTB/POZ domain
PF02178 - AT hook motif
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
54695 - POZ domain
57667 - beta-beta-alpha zinc fingers
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like
57850 - RING/U-box
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on Q9HD72
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated


-  Descriptions from all associated GenBank mRNAs
  LF208970 - JP 2014500723-A/16473: Polycomb-Associated Non-Coding RNAs.
MA444547 - JP 2018138019-A/16473: Polycomb-Associated Non-Coding RNAs.
AL096880 - Novel human mRNA containing Zinc finger C2H2 type domains.
AY028384 - Homo sapiens BTB-POZ domain zinc finger transcription factor (RIAZ) mRNA, complete cds.
AF254083 - Homo sapiens zinc finger sarcoma gene long A isoform (ZSG) mRNA, complete cds.
AF254084 - Homo sapiens zinc finger sarcoma gene long B isoform (ZSG) mRNA, complete cds.
AF254085 - Homo sapiens zinc finger sarcoma gene long C isoform (ZSG) mRNA, complete cds.
BC051357 - Homo sapiens zinc finger protein 278, mRNA (cDNA clone IMAGE:6598836), partial cds.
AB208787 - Homo sapiens mRNA for zinc finger protein 278 long A isoform variant protein.
LF213766 - JP 2014500723-A/21269: Polycomb-Associated Non-Coding RNAs.
CR456613 - Homo sapiens ZNF278 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.ZNF278).
AF254087 - Homo sapiens EWS/ZSG fusion protein long A isoform (EWS/ZSG fusion) mRNA, complete cds.
AF254088 - Homo sapiens EWS/ZSG fusion protein long B isoform (EWS/ZSG fusion) mRNA, complete cds.
CU013210 - Homo sapiens ZNF278, mRNA (cDNA clone IMAGE:100000564), complete cds, with stop codon, in Gateway system.
CU013498 - Homo sapiens ZNF278, mRNA (cDNA clone IMAGE:100000468), complete cds, without stop codon, in Gateway system.
AB384725 - Synthetic construct DNA, clone: pF1KB3020, Homo sapiens PATZ1 gene for POZ-, AT hook-, and zinc finger-containing protein 1, complete cds, without stop codon, in Flexi system.
AK123441 - Homo sapiens cDNA FLJ41447 fis, clone BRSTN2004869.
AF119256 - Homo sapiens PATZ (PATZ) mRNA, complete cds.
BC021091 - Homo sapiens POZ (BTB) and AT hook containing zinc finger 1, mRNA (cDNA clone MGC:31750 IMAGE:4857537), complete cds.
AF254082 - Homo sapiens zinc finger sarcoma gene short isoform (ZSG) mRNA, complete cds.
JD101464 - Sequence 82488 from Patent EP1572962.
JD132262 - Sequence 113286 from Patent EP1572962.
JD484815 - Sequence 465839 from Patent EP1572962.
JD219128 - Sequence 200152 from Patent EP1572962.
JD135257 - Sequence 116281 from Patent EP1572962.
JD084341 - Sequence 65365 from Patent EP1572962.
AK291803 - Homo sapiens cDNA FLJ76669 complete cds, highly similar to Homo sapiens zinc finger protein 278 (ZNF278), transcript variant 4, mRNA.
JD393338 - Sequence 374362 from Patent EP1572962.
JD297613 - Sequence 278637 from Patent EP1572962.
JD370868 - Sequence 351892 from Patent EP1572962.
JD117628 - Sequence 98652 from Patent EP1572962.
JD223433 - Sequence 204457 from Patent EP1572962.
KJ898519 - Synthetic construct Homo sapiens clone ccsbBroadEn_07913 PATZ1 gene, encodes complete protein.
LF324539 - JP 2014500723-A/132042: Polycomb-Associated Non-Coding RNAs.
AF242522 - Homo sapiens krueppel-related zinc finger protein SBZF5 mRNA, complete cds.
LF324538 - JP 2014500723-A/132041: Polycomb-Associated Non-Coding RNAs.
JD142404 - Sequence 123428 from Patent EP1572962.
LF324537 - JP 2014500723-A/132040: Polycomb-Associated Non-Coding RNAs.
JD446006 - Sequence 427030 from Patent EP1572962.
JD445823 - Sequence 426847 from Patent EP1572962.
JD533526 - Sequence 514550 from Patent EP1572962.
MA560116 - JP 2018138019-A/132042: Polycomb-Associated Non-Coding RNAs.
MA560115 - JP 2018138019-A/132041: Polycomb-Associated Non-Coding RNAs.
MA560114 - JP 2018138019-A/132040: Polycomb-Associated Non-Coding RNAs.
MA449343 - JP 2018138019-A/21269: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000215919.1, ENST00000215919.2, NM_032051, Q9HD72, Q9HD72_HUMAN, uc317cnk.1, uc317cnk.2
UCSC ID: ENST00000215919.3_5
RefSeq Accession: NM_032051.2
Protein: Q9HD72

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.