Human Gene PARK7 (ENST00000338639.10_4) from GENCODE V47lift37
  Description: Parkinsonism associated deglycase, transcript variant 1 (from RefSeq NM_007262.5)
Gencode Transcript: ENST00000338639.10_4
Gencode Gene: ENSG00000116288.13_11
Transcript (Including UTRs)
   Position: hg19 chr1:8,021,771-8,045,565 Size: 23,795 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr1:8,022,846-8,045,114 Size: 22,269 Coding Exon Count: 6 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
GeneReviewsModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:8,021,771-8,045,565)mRNA (may differ from genome)Protein (189 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PARK7
Diseases sorted by gene-association score: parkinson disease 7, autosomal recessive early-onset* (1200), parkinson disease 6, early onset* (283), parkinson disease, juvenile, type 2* (157), park7-related parkinson disease* (100), amyotrophic lateral sclerosis-parkinsonism/dementia complex* (39), early-onset parkinson disease (26), snca-related parkinson disease (9), parkinson disease, late-onset (8), movement disease (7), parkinson disease 10 (7), supranuclear palsy, progressive (7), parkinson disease susceptibility (6), dementia, lewy body (5), parkinson disease 15, autosomal recessive (5), dementia (4), synucleinopathy (2), nervous system disease (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 137.56 RPKM in Adrenal Gland
Total median expression: 4494.51 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -38.30106-0.361 Picture PostScript Text
3' UTR -101.00451-0.224 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  AF021819 - Homo sapiens RNA-binding protein regulatory subunit mRNA, complete cds.
AK312000 - Homo sapiens cDNA, FLJ92274, highly similar to Homo sapiens Parkinson disease (autosomal recessive, early onset) 7 (PARK7), mRNA.
AK130886 - Homo sapiens cDNA FLJ27376 fis, clone UBA06221, highly similar to Homo sapiens RNA-binding protein regulatory subunit.
BC008188 - Homo sapiens Parkinson disease (autosomal recessive, early onset) 7, mRNA (cDNA clone MGC:5243 IMAGE:2901102), complete cds.
D61380 - Homo sapiens mRNA for DJ-1 protein, complete cds.
EU794641 - Homo sapiens epididymis secretory sperm binding protein Li 67p (HEL-S-67p) mRNA, complete cds.
AB464000 - Synthetic construct DNA, clone: pF1KB6832, Homo sapiens PARK7 gene for Parkinson disease 7, without stop codon, in Flexi system.
HQ447919 - Synthetic construct Homo sapiens clone IMAGE:100071277; CCSB002686_04 Parkinson disease (autosomal recessive, early onset) 7 (PARK7) gene, encodes complete protein.
AB073864 - Homo sapiens mRNA for DJ-1, complete cds.
DQ588074 - Homo sapiens piRNA piR-55186, complete sequence.
DQ588075 - Homo sapiens piRNA piR-55187, complete sequence.
DQ585430 - Homo sapiens piRNA piR-52542, complete sequence.
AK091679 - Homo sapiens cDNA FLJ34360 fis, clone FEBRA2014198.
AX747125 - Sequence 650 from Patent EP1308459.
JD248035 - Sequence 229059 from Patent EP1572962.
JD411135 - Sequence 392159 from Patent EP1572962.
JD195608 - Sequence 176632 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000338639.1, ENST00000338639.2, ENST00000338639.3, ENST00000338639.4, ENST00000338639.5, ENST00000338639.6, ENST00000338639.7, ENST00000338639.8, ENST00000338639.9, HEL-S-67p , NM_007262, uc317vch.1, uc317vch.2, V9HWC2, V9HWC2_HUMAN
UCSC ID: ENST00000338639.10_4
RefSeq Accession: NM_007262.5

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene PARK7:
parkinson-overview (Parkinson Disease Overview)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.