ID:PAR6B_HUMAN DESCRIPTION: RecName: Full=Partitioning defective 6 homolog beta; Short=PAR-6 beta; Short=PAR-6B; FUNCTION: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. SUBUNIT: Interacts with PARD3. Interacts with GTP-bound forms of CDC42 and RAC1. Interacts with GTP-bound ARHQ/TC10. Interacts with MPP5 (By similarity). Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with ALS2CR19. Interacts with ECT2. INTERACTION: P60953:CDC42; NbExp=7; IntAct=EBI-295391, EBI-81752; Q8TEW0:PARD3; NbExp=4; IntAct=EBI-295391, EBI-81968; Q8ND90:PNMA1; NbExp=2; IntAct=EBI-295391, EBI-302345; P41743:PRKCI; NbExp=9; IntAct=EBI-295391, EBI-286199; Q05513:PRKCZ; NbExp=3; IntAct=EBI-295391, EBI-295351; P63000:RAC1; NbExp=3; IntAct=EBI-295391, EBI-413628; Q04917:YWHAH; NbExp=2; IntAct=EBI-295391, EBI-306940; SUBCELLULAR LOCATION: Cytoplasm. Cell membrane (By similarity). Cell junction, tight junction (By similarity). TISSUE SPECIFICITY: Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues. DOMAIN: The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases. DOMAIN: The PDZ domain mediates interaction with MPP5 (By similarity). SIMILARITY: Belongs to the PAR6 family. SIMILARITY: Contains 1 OPR domain. SIMILARITY: Contains 1 PDZ (DHR) domain. SIMILARITY: Contains 1 pseudo-CRIB domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BYG5
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
