ID:PAOX_HUMAN DESCRIPTION: RecName: Full=Peroxisomal N(1)-acetyl-spermine/spermidine oxidase; EC=1.5.3.13; AltName: Full=Polyamine oxidase; FUNCTION: Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)- acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. CATALYTIC ACTIVITY: N(1)-acetylspermine + O(2) + H(2)O = spermidine + 3-acetamidopropanal + H(2)O(2). CATALYTIC ACTIVITY: N(1)-acetylspermidine + O(2) + H(2)O = putrescine + 3-acetamidopropanal + H(2)O(2). CATALYTIC ACTIVITY: N(1),N(12)-diacetylspermine + O(2) + H(2)O = N(1)-acetylspermidine + 3-acetamidobutanal + H(2)O(2). COFACTOR: Binds 1 FAD per subunit (By similarity). PATHWAY: Amine and polyamine metabolism; spermine metabolism. SUBUNIT: Monomer (By similarity). SUBCELLULAR LOCATION: Peroxisome (By similarity). Cytoplasm (By similarity). TISSUE SPECIFICITY: Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues. INDUCTION: By polyamine analogs. MISCELLANEOUS: Oxidizes N(1)-acetylated polyamines on the exo-side of their N(4)-amino groups. Plant PAO oxidizes spermine on the endo-side of the N(4)-nitrogen (By similarity). SIMILARITY: Belongs to the flavin monoamine oxidase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6QHF9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006596 polyamine biosynthetic process GO:0006598 polyamine catabolic process GO:0006625 protein targeting to peroxisome GO:0008215 spermine metabolic process GO:0009446 putrescine biosynthetic process GO:0009447 putrescine catabolic process GO:0046203 spermidine catabolic process GO:0046208 spermine catabolic process GO:0055114 oxidation-reduction process GO:1901307 positive regulation of spermidine biosynthetic process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
