Human Gene P2RY10 (ENST00000171757.3_4) from GENCODE V47lift37

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Description: P2Y receptor family member 10, transcript variant 1 (from RefSeq NM_014499.4)
Gencode Transcript: ENST00000171757.3_4
Gencode Gene: ENSG00000078589.13_7
Transcript (Including UTRs)
Position: hg19 chrX:78,200,888-78,219,224 Size: 18,337 Total Exon Count: 4 Strand: +
Coding Region
Position: hg19 chrX:78,216,018-78,217,037 Size: 1,020 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chrX:78,200,888-78,219,224)			mRNA (may differ from genome)		Protein (339 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: P2Y10_HUMAN DESCRIPTION: RecName: Full=Putative P2Y purinoceptor 10; Short=P2Y10; AltName: Full=P2Y-like receptor; FUNCTION: Putative receptor for purines coupled to G-proteins. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Weakly expressed in blood leukocytes. DEVELOPMENTAL STAGE: Up-regulated during promyelocytic cell differentiation along the monocytic pathway, but not during granulocytic differentiation. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine D002117 Calcitriol D002737 Chloroprene D002794 Choline D005492 Folic Acid D005839 Gentamicins D008715 Methionine D018038 Sodium Selenite C015001 arsenite C006253 pirinixic acid

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 42.36 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 57.89 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-66.70	310	-0.215	Picture	PostScript	Text
3' UTR	-482.30	2187	-0.221	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR002286 - P2_purnocptor

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on O00398


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004871 signal transducer activity GO:0004930 G-protein coupled receptor activity GO:0045028 G-protein coupled purinergic nucleotide receptor activity Biological Process: GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0035025 positive regulation of Rho protein signal transduction GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Cellular Component: GO:0005886 plasma membrane GO:0005887 integral component of plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	AK313218 - Homo sapiens cDNA, FLJ93719. AK292138 - Homo sapiens cDNA FLJ75782 complete cds, highly similar to Homo sapiens purinergic receptor P2Y, G-protein coupled, 10 (P2RY10), transcript variant 1, mRNA. BC051875 - Homo sapiens purinergic receptor P2Y, G-protein coupled, 10, mRNA (cDNA clone MGC:60256 IMAGE:5212240), complete cds. JD298161 - Sequence 279185 from Patent EP1572962. CU690880 - Synthetic construct Homo sapiens gateway clone IMAGE:100021415 5' read P2RY10 mRNA. AB464109 - Synthetic construct DNA, clone: pF1KB7144, Homo sapiens P2RY10 gene for purinergic receptor P2Y, G-protein coupled, 10, without stop codon, in Flexi system. KJ893636 - Synthetic construct Homo sapiens clone ccsbBroadEn_03030 P2RY10 gene, encodes complete protein. BC095498 - Homo sapiens purinergic receptor P2Y, G-protein coupled, 10, mRNA (cDNA clone MGC:111701 IMAGE:6971933), complete cds.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein O00398 (Reactome details) participates in the following event(s): R-HSA-417842 P2Y10 receptor can bind to LPA R-HSA-749452 The Ligand:GPCR:Gq complex dissociates R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 R-HSA-417957 P2Y receptors R-HSA-416476 G alpha (q) signalling events R-HSA-418038 Nucleotide-like (purinergic) receptors R-HSA-388396 GPCR downstream signalling R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-372790 Signaling by GPCR R-HSA-500792 GPCR ligand binding R-HSA-162582 Signal Transduction

Other Names for This Gene


	Alternate Gene Symbols: D3DTE5, ENST00000171757.1, ENST00000171757.2, NM_014499, O00398, P2Y10_HUMAN, Q4VBN7, Q86V16, uc317cee.1, uc317cee.2 UCSC ID: ENST00000171757.3_4 RefSeq Accession: NM_014499.4 Protein: O00398 (aka P2Y10_HUMAN or P2YA_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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