ID:OTUD5_HUMAN DESCRIPTION: RecName: Full=OTU domain-containing protein 5; EC=3.4.19.12; AltName: Full=Deubiquitinating enzyme A; Short=DUBA; FUNCTION: Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'- linked ubiquitin chains (in vitro). CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). ENZYME REGULATION: Inhibited by N-ethyl-maleimide (NEM). SUBUNIT: Interacts with TRAF3. TISSUE SPECIFICITY: Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes. INDUCTION: Up-regulated by bacterial lipopolysaccharide (LPS) in bone marrow-derived macrophages. PTM: Phosphorylation at Ser-177 is required for deubiquitinating activity. SIMILARITY: Belongs to the peptidase C85 family. SIMILARITY: Contains 1 OTU domain. SEQUENCE CAUTION: Sequence=BAB14131.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB15416.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96G74
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006508 proteolysis GO:0016579 protein deubiquitination GO:0032480 negative regulation of type I interferon production GO:0032496 response to lipopolysaccharide GO:0070536 protein K63-linked deubiquitination GO:0071108 protein K48-linked deubiquitination
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
