Human Gene OSBPL11 (ENST00000296220.6_7) from GENCODE V47lift37

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Description: oxysterol binding protein like 11 (from RefSeq NM_022776.5)
Gencode Transcript: ENST00000296220.6_7
Gencode Gene: ENSG00000144909.8_9
Transcript (Including UTRs)
Position: hg19 chr3:125,247,702-125,314,341 Size: 66,640 Total Exon Count: 13 Strand: -
Coding Region
Position: hg19 chr3:125,249,359-125,313,644 Size: 64,286 Coding Exon Count: 13

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:125,247,702-125,314,341)			mRNA (may differ from genome)		Protein (747 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: OSB11_HUMAN DESCRIPTION: RecName: Full=Oxysterol-binding protein-related protein 11; Short=ORP-11; Short=OSBP-related protein 11; TISSUE SPECIFICITY: Widely expressed. SIMILARITY: Belongs to the OSBP family. SIMILARITY: Contains 1 PH domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin C016403 2,4-dinitrotoluene D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D001104 Arbutin D001564 Benzo(a)pyrene D002922 Ciguatoxins D016572 Cyclosporine D004958 Estradiol D007501 Iron D011374 Progesterone more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 21.01 RPKM in Muscle - Skeletal Total median expression: 254.76 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-275.00	697	-0.395	Picture	PostScript	Text
3' UTR	-366.40	1657	-0.221	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000648 - Oxysterol-bd
IPR018494 - Oxysterol-bd_CS
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology

Pfam Domains:
PF00169 - PH domain
PF01237 - Oxysterol-binding protein
PF15409 - Pleckstrin homology domain

SCOP Domains:
50729 - PH domain-like
143880 - NE0471 N-terminal domain-like
144000 - Oxysterol-binding protein-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2D9X - NMR MuPIT

ModBase Predicted Comparative 3D Structure on Q9BXB4


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0008289 lipid binding Biological Process: GO:0006869 lipid transport GO:0010890 positive regulation of sequestering of triglyceride GO:0045444 fat cell differentiation Cellular Component: GO:0005654 nucleoplasm GO:0005768 endosome GO:0005794 Golgi apparatus GO:0016020 membrane GO:0031902 late endosome membrane

Descriptions from all associated GenBank mRNAs


	BC065213 - Homo sapiens oxysterol binding protein-like 11, mRNA (cDNA clone MGC:74549 IMAGE:3916115), complete cds. AF392454 - Homo sapiens oxysterol-binding protein-like protein OSBPL11 (OSBPL11) mRNA, complete cds. AK292702 - Homo sapiens cDNA FLJ76960 complete cds, highly similar to Homo sapiens oxysterol binding protein-like 11 (OSBPL11), mRNA. HM005445 - Homo sapiens clone HTL-T-132 testicular tissue protein Li 132 mRNA, complete cds. EU831807 - Synthetic construct Homo sapiens clone HAIB:100066836; DKFZo008F0321 oxysterol binding protein-like 11 protein (OSBPL11) gene, encodes complete protein. EU831884 - Synthetic construct Homo sapiens clone HAIB:100066913; DKFZo004F0322 oxysterol binding protein-like 11 protein (OSBPL11) gene, encodes complete protein. AB384762 - Synthetic construct DNA, clone: pF1KB3224, Homo sapiens OSBPL11 gene for oxysterol-binding protein-related protein 11, complete cds, without stop codon, in Flexi system. AF346292 - Homo sapiens OSBP related protein 11 mRNA, partial cds. AY007102 - Homo sapiens clone TCCCIA00292 mRNA sequence. BC010422 - Homo sapiens oxysterol binding protein-like 11, mRNA (cDNA clone IMAGE:3028650), complete cds. AK023226 - Homo sapiens cDNA FLJ13164 fis, clone NT2RP3003659, weakly similar to HES1 PROTEIN. JD566277 - Sequence 547301 from Patent EP1572962. JD113956 - Sequence 94980 from Patent EP1572962. JD243927 - Sequence 224951 from Patent EP1572962. AK023074 - Homo sapiens cDNA FLJ13012 fis, clone NT2RP3000578, weakly similar to HES1 PROTEIN. JD382009 - Sequence 363033 from Patent EP1572962. JD267814 - Sequence 248838 from Patent EP1572962. JD245558 - Sequence 226582 from Patent EP1572962. JD065603 - Sequence 46627 from Patent EP1572962. JD178034 - Sequence 159058 from Patent EP1572962. JD040705 - Sequence 21729 from Patent EP1572962. JD556944 - Sequence 537968 from Patent EP1572962. JD081993 - Sequence 63017 from Patent EP1572962. JD369254 - Sequence 350278 from Patent EP1572962. JD181911 - Sequence 162935 from Patent EP1572962. JD534322 - Sequence 515346 from Patent EP1572962. JD253512 - Sequence 234536 from Patent EP1572962. JD084005 - Sequence 65029 from Patent EP1572962. JD224501 - Sequence 205525 from Patent EP1572962. JD530982 - Sequence 512006 from Patent EP1572962. JD145954 - Sequence 126978 from Patent EP1572962. JD266820 - Sequence 247844 from Patent EP1572962. JD292608 - Sequence 273632 from Patent EP1572962. JD250504 - Sequence 231528 from Patent EP1572962. JD094624 - Sequence 75648 from Patent EP1572962. JD094623 - Sequence 75647 from Patent EP1572962. JD314913 - Sequence 295937 from Patent EP1572962. JF432682 - Synthetic construct Homo sapiens clone IMAGE:100073920 oxysterol binding protein-like 11 (OSBPL11) gene, encodes complete protein. KJ903648 - Synthetic construct Homo sapiens clone ccsbBroadEn_13042 OSBPL11 gene, encodes complete protein. JD516124 - Sequence 497148 from Patent EP1572962. AF318344 - Homo sapiens pp14733 mRNA, complete cds. JD435227 - Sequence 416251 from Patent EP1572962. JD172107 - Sequence 153131 from Patent EP1572962. JD394548 - Sequence 375572 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A8K9I7, ENST00000296220.1, ENST00000296220.2, ENST00000296220.3, ENST00000296220.4, ENST00000296220.5, NM_022776, ORP11, OSB11_HUMAN, OSBP12, Q9BXB4, uc317lrz.1, uc317lrz.2 UCSC ID: ENST00000296220.6_7 RefSeq Accession: NM_022776.5 Protein: Q9BXB4 (aka OSB11_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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