Human Gene OR2G6 (ENST00000641501.1_7) from GENCODE V47lift37

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Description: Odorant receptor. (from UniProt Q5TZ20)
Gencode Transcript: ENST00000641501.1_7
Gencode Gene: ENSG00000188558.7_13
Transcript (Including UTRs)
Position: hg19 chr1:248,672,837-248,690,638 Size: 17,802 Total Exon Count: 2 Strand: +
Coding Region
Position: hg19 chr1:248,684,948-248,685,898 Size: 951 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions	Pathways
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:248,672,837-248,690,638)			mRNA (may differ from genome)		Protein (316 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	ExonPrimer	GeneCards	HGNC	MGI
PubMed	Reactome	UniProtKB	Wikipedia

Comments and Description Text from UniProtKB


	ID: OR2G6_HUMAN DESCRIPTION: RecName: Full=Olfactory receptor 2G6; FUNCTION: Odorant receptor (Potential). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); URL="http://bip.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR2G6";

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen

Common Gene Haplotype Alleles


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-21.20	149	-0.142	Picture	PostScript	Text
3' UTR	-1180.30	4740	-0.249	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR000725 - Olfact_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF13853 - Olfactory receptor

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q5TZ20


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004871 signal transducer activity GO:0004930 G-protein coupled receptor activity GO:0004984 olfactory receptor activity Biological Process: GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007608 sensory perception of smell GO:0050896 response to stimulus GO:0050911 detection of chemical stimulus involved in sensory perception of smell Cellular Component: GO:0005886 plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	BC137266 - Homo sapiens olfactory receptor, family 2, subfamily G, member 6, mRNA (cDNA clone MGC:168886 IMAGE:9021263), complete cds. BC137245 - Homo sapiens olfactory receptor, family 2, subfamily G, member 6, mRNA (cDNA clone MGC:168865 IMAGE:9021242), complete cds. KJ900716 - Synthetic construct Homo sapiens clone ccsbBroadEn_10110 OR2G6 gene, encodes complete protein. JD212487 - Sequence 193511 from Patent EP1572962. JD197864 - Sequence 178888 from Patent EP1572962. JD412918 - Sequence 393942 from Patent EP1572962. JD071048 - Sequence 52072 from Patent EP1572962. JD430397 - Sequence 411421 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q5TZ20 (Reactome details) participates in the following event(s): R-HSA-381750 Olfactory Receptor - G Protein olfactory trimer complex formation R-HSA-381753 Olfactory Signaling Pathway R-HSA-418555 G alpha (s) signalling events R-HSA-388396 GPCR downstream signalling R-HSA-372790 Signaling by GPCR R-HSA-162582 Signal Transduction

Other Names for This Gene


	Alternate Gene Symbols: B2RP33, OR2G6_HUMAN, Q5TZ20, uc328hmy.1 UCSC ID: ENST00000641501.1_7 RefSeq Accession: NM_001013355.2 Protein: Q5TZ20 (aka OR2G6_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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